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VOLUME 24 , ISSUE 2 ( February, 2023 ) > List of Articles


Reasons for Failure of CAD/CAM Restorations in Clinical Studies: A Systematic Review and Meta-analysis

Stephan lampl, Jogikalmat Krithikadatta, Deepak Mehta, Desigar Moodley

Keywords : Biological complications, Computer-aided design/computer-aided manufacture materials, Computer-aided design/computer-aided manufacture failure rates, Computer-aided design/computer-aided manufacture success rates, Computer-aided design/computer-aided manufacture survival rates, Technical complications

Citation Information : lampl S, Krithikadatta J, Mehta D, Moodley D. Reasons for Failure of CAD/CAM Restorations in Clinical Studies: A Systematic Review and Meta-analysis. J Contemp Dent Pract 2023; 24 (2):129-136.

DOI: 10.5005/jp-journals-10024-3472

License: CC BY-NC 4.0

Published Online: 23-05-2023

Copyright Statement:  Copyright © 2023; The Author(s).


Aim: The systematic review presented herein was performed to descriptively analyze the causes for the failure of computer-aided design/computer-aided manufacture (CAD/CAM) restorations. The meta-analysis reported herein was performed to estimate long-term survival and success rates of CAD–CAM fabrications. Materials and methods: Using the PICOS paradigm, a systematic search was carried out in the PubMed and Cochrane databases to identify randomized controlled trials (RCTs) and prospective observational studies reporting survival data for CAD/CAM restorations. After selecting studies with a predefined set of selection criteria, data from included prospective clinical studies and RCTs were used for a systematic review aimed at a descriptive analysis of factors associated with failure of CAD–CAM restorations. Data from the included prospective clinical studies were used for meta-analysis, wherein 5-year and 10-year survival and success rates were estimated using Poisson regression models. Results: The systematic review included data from 9 RCTs and 6 observational studies, which had a median follow-up of 36 months and 60 months, respectively. About 58 failures and 118 technical/biological complications were noted in the included RCTs and 9 failures along with 58 technical/biological complications were noted in the prospective clinical studies. Poisson regression indicated an estimated 5-year and 10-year survival rates of 85.55–100 and 71–100, respectively. The estimated 5-year and 10-year success rates were 74.2–92.75 and 33.3–85.5, respectively. Conclusion: Several technical and biological complications contribute to failure of CAD/CAM restorations. However, CAD/CAM restorations with routine chairside materials might have clinically meaningful success rates in the long term. Clinical significance: The results presented herein indicate that optimal strategies for mitigation of biological and technical complications may augment the success of CAD/CAM fabrications in restorative dentistry. Studies aimed at identification of such strategies are needed to further enhance the long-term success rates of CAD/CAM restorations.

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