Aim: This study evaluates compressive stress in teeth restored with endocrown (ECW) and build-up (BUP) using finite element analysis (FEA). Understanding stress distribution in dental restorations is crucial for improving treatment outcomes and longevity. Materials and methods: A second lower molar was modeled using Solidworks® (Version 2017). The ECW was simulated with nanoceramic resin, while the BUP included a core and nanoceramic crown. Mechanical properties, including modulus of elasticity, Poisson's ratio, and tensile strength were assigned to materials. Axial and oblique loads of 900N were applied, and stress was analyzed using Solidworks®. Results: Results indicated that under axial loading, ECW experienced a maximum stress of 91.9 MPa, significantly higher than BUP's 49 MPa. Under oblique loading, ECW exhibited 132 MPa compared with 116 MPa in BUP. The highest stress concentration was in the cervical area, where ECW showed greater stresses in both the substrate and restored area. Build-up demonstrated better stress distribution and lower fracture risk. Conclusion: Endocrown restoration results in higher compressive stresses, especially in the cervical region, which may increase the risk of fracture. Conversely, the BUP technique, which preserves cervical dentin, offers improved stress distribution and reduced fracture risk, making it a more robust solution for endodontic rehabilitation. Clinical significance: This study underscores the importance of selecting appropriate restoration methods to minimize stress and enhance the longevity of dental treatments, ultimately leading to better patient outcomes.