Aim: Preservation of ridge dimensions is the important aspect after tooth extraction for prosthetic and implant rehabilitation. Titanium-platelet rich fibrin (T-PRF) is an autologous biomaterial, and when used with bone graft it could enhance the bone regeneration. Hence, the aim of this study was to evaluate the combined effect of T-PRF with nanocrystalline hydroxyapatite (Nano-HA) and T-PRF with demineralized bone matrix (DMBM). Materials and methods: Twenty systemically healthy patients were included in the study and were randomly assigned into two groups. Ten patients were treated with atraumatic extraction followed by ridge preservation using Nano-HA bone graft and T-PRF. In another group of ten patients, ridge preservation was done using a xenograft-DMBM. Preoperative cone beam computed tomography (CBCT) and postoperative CBCT after 3 months were evaluated for bone fill. The clinical parameters of ridge width (RW) and ridge height were measured clinically, with the help of UNC 15 probe, after 3 months. Results: The treatment modality resulted in significant bone fill in CBCT and adequate RW clinically in both the groups. The mean bone density in the Nano-HA + T-PRF group was recorded as 776.72 ± 223.94, and 854.72 ± 183.57 was observed in the DMBM + T-PRF group, after 14−16 weeks. Conclusion: The study's findings indicate that ridge preservation performed at the time of extraction is a reliable and predictable approach for minimizing alveolar bone resorption. Additionally, the combination of T-PRF with bone grafts yields effective results in a relatively short timeframe. Clinical significance: This technique involves combining osteoconductive material from Nano-HA and DMBM and the growth factor-rich matrix of T PRF for quicker healing and better esthetic and functional results. It reduces morbidity in patients, does not require an autogenous graft, is biocompatible, and is economical; therefore, both clinical practice and regenerative research in the field of dentistry are advanced. Hence, it is one of the important evidences through this original study.