Citation Information :
Mendoza R, Calderón I. Overview, Trends, and Collaboration on Immunization, Vaccination, and Immunomodulation Therapies for Periodontitis: A Scientometric Study. J Contemp Dent Pract 2024; 25 (2):128-133.
Aim: To identify patterns and trends in the field of immunization, vaccination, and immunomodulation therapies for periodontitis.
Materials and methods: Metadata were collected from the Scopus database on publications related to these topics from January 1986 to February 2024. Several types of papers were included in this study, a total of 22 publications. Data were extracted from relevant publications and loaded into SciVal for analysis that were used to identify trends and patterns in the data, including cross-country collaboration, thematic evolution, and keyword distribution.
Results: Mohsen Amin of Tehran University of Medical Sciences in Iran and S. Aadil Ahamed and Annie Kitty George of Saveetha Institute of Medical and Technical Sciences in India were found to be notable contributors in this field. India leads in terms of academic paper production, followed by Iran and China. The journals Expert Review of Vaccines and International Immunopharmacology have published significant papers in this field.
Conclusions: According to Lotka's Law, most authors have written only one paper, reflecting the distribution of productivity in many academic and scientific fields. Collaborations were observed between Iran and Canada, Korea and New Zealand, and the United States and Belgium. This study provides useful insight into the predominant trends and patterns in the scientific literature in the field of immunization, vaccination, and immunomodulation therapies for periodontitis.
Clinical significance: The findings of this study may help to understand the dynamics of the production on immunization, vaccination, and immunomodulation therapies could reduce the inflammation and progression of periodontitis, thus improving the patient's oral and overall health.
Costalonga M, Herzberg MC. The oral microbiome and the immunobiology of periodontal disease and caries. Immunol Lett 2014;162(2):22–38. DOI: 10.1016/j.imlet.2014.08.017.
Armitage GC. Periodontal diagnoses and classification of periodontal diseases. Periodontol 2000 2004;34:9–21. DOI: 10.1046/j.0906-6713.2002.003421.x.
Papapanou PN, Sanz M, Buduneli N, et al. Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the classification of periodontal and peri-implant diseases and conditions. J Periodontol 2018;89(1):173–182. DOI: 10.1002/JPER.17-0721.
Dörfer C, Benz C, Aida J, et al. The relationship of oral health with general health and NCDs: A brief review. Int Dent J 2017;67 Suppl 2(Suppl 2):14–18. DOI: 10.1111/idj.12360.
Hajishengallis G. Periodontitis: From microbial immune subversion to systemic inflammation. Nat Rev Immunol 2015;15(1):30–44. DOI: 10.1038/nri3785.
Hasan A, Palmer RM. A clinical guide to periodontology: Pathology of periodontal disease. Br Dent J 2014;216(8):457–461. DOI: 10.1038/sj.bdj.2014.299.
Shi B, Chang M, Martin J, et al. Dynamic changes in the subgingival microbiome and their potential for diagnosis and prognosis of periodontitis. mBio 2015;6(1):e01926-14. DOI: 10.1128/mBio.01926-14.
Hajishengallis G. Immunomicrobial pathogenesis of periodontitis: Keystones, pathobionts, and host response. Trends Immunol 2014;35(1):3–11. DOI:10.1016/j.it.2013.09.001.
Socransky SS, Haffajee AD. Evidence of bacterial etiology: A historical perspective. Periodontol 2000 1994;5:7–25. DOI: 10.1111/j.1600-0757.1994.tb00016.x.
Yang B, Pang X, Li Z, et al. Immunomodulation in the treatment of periodontitis: Progress and perspectives. Front Immunol 2021;12:781378. DOI: 10.3389/fimmu.2021.781378.
Aruni AW, Dou Y, Mishra A, et al. The biofilm community-rebels with a cause. Curr Oral Health Rep 2015;2(1):48–56. DOI: 10.1007/s40496-014-0044-5.
Guimarães MV, Melo IM, Araújo A, et al. Dry extract of Matricaria recutita L. (Chamomile) prevents ligature-induced alveolar bone resorption in rats via inhibition of tumor necrosis factor-α and interleukin-1β. J Periodontol 2016;87(6):706–715. DOI: 10.1902/jop.2016.150411.
Ricciotti E, FitzGerald GA. Prostaglandins and inflammation. Arterioscler Thromb Vasc Biol 2011;31(5):986–1000. DOI: 10.1161/ATVBAHA.110.207449.
Jagadish R, Mehta DS. Comparative evaluation of the efficacy of the cyclooxygenase pathway inhibitor and nitric oxide synthase inhibitor in the reduction of alveolar bone loss in ligature induced periodontitis in rats: An experimental study. J Indian Soc Periodontol 2014;18(1):59–64. DOI:10.4103/0972-124X.128216.
Moro MG, Oliveira MDDS, Oliveira LR, et al. Effects of selective versus non-selective COX-2 inhibition on experimental periodontitis. Braz Dent J 2019;30(2):133–138. DOI: 10.1590/0103-6440201902241.
Chen B, Wu W, Sun W, et al. RANKL expression in periodontal disease: Where does RANKL come from? Biomed Res Int 2014;2014:731039. DOI: 10.1155/2014/731039.
Kim KW, Cho ML, Lee SH, et al. Human rheumatoid synovial fibroblasts promote osteoclastogenic activity by activating RANKL via TLR-2 and TLR-4 activation. Immunol Lett 2007;110(1):54–64. DOI: 10.1016/j.imlet.2007.03.004.
Sikora AE, Gomez C, Le Van A, et al. A novel gonorrhea vaccine composed of MetQ lipoprotein formulated with CpG shortens experimental murine infection. Vaccine 2020;38(51):8175–8184. DOI: 10.1016/j.vaccine.2020.10.077.
Kong F, Zheng D, She P, et al. Porphyromonas gingivalis B cell antigen epitope vaccine, pIRES-ragB’-mGITRL, promoted RagB-specific antibody production and Tfh cells expansion. Scand J Immunol 2015;81(6):476–482. DOI: 10.1111/sji.12281.
Nakao R, Hasegawa H, Dongying B, et al. Assessment of outer membrane vesicles of periodontopathic bacterium Porphyromonas gingivalis as possible mucosal immunogen. Vaccine 2016;34(38):4626–4634. DOI: 10.1016/j.vaccine.2016.06.016.
O'Brien-Simpson NM, Holden JA, Lenzo JC, et al. A therapeutic Porphyromonas gingivalis gingipain vaccine induces neutralising IgG1 antibodies that protect against experimental periodontitis. NPJ Vaccines 2016;1(1):16022. DOI:10.1038/npjvaccines.2016.22.
Puth S, Hong SH, Na HS, et al. A built-in adjuvant-engineered mucosal vaccine against dysbiotic periodontal diseases. Mucosal Immunol 2019;12(2):565–579. PMID: 30487648.