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VOLUME 25 , ISSUE 2 ( February, 2024 ) > List of Articles


Evaluation of Regenerative Efficacy of Amnion and Chorion Membrane in Treatment of Mandibular Molar Furcation Defects: A Clinico-radiographic Study

Siddharth Mallapragda, Radhika Gupta, Stuti Gupta, Himani Sharma, Saransh Srivastava, Anusha Raj

Keywords : Amnion membrane, Chorion membrane, Demineralized freeze-dried bone allograft, Furcation, Periodontal regeneration

Citation Information : Mallapragda S, Gupta R, Gupta S, Sharma H, Srivastava S, Raj A. Evaluation of Regenerative Efficacy of Amnion and Chorion Membrane in Treatment of Mandibular Molar Furcation Defects: A Clinico-radiographic Study. J Contemp Dent Pract 2024; 25 (2):160-167.

DOI: 10.5005/jp-journals-10024-3640

License: CC BY-NC 4.0

Published Online: 14-03-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Aim: Amnion and chorion membranes possess unique inherited biological properties that enhance wound healing and may accelerate periodontal regeneration. The present study aims to evaluate and compare the efficacy of amnion and chorion membranes in the treatment of furcation defects. Materials and methods: A total of 20 patients were selected and were randomly allocated to group I and group II with 10 subjects in each group. Amnion and chorion membranes are placental-derived membranes that accelerate regeneration by having natural growth factors with their antimicrobial and inflammation reduction properties. Group I was treated using bone grafting with decalcified freeze-dried bone allograft (DFDBA) and placement of amnion as a membrane for guided tissue regeneration (GTR) whereas group II was treated using bone grafting with DFDBA and placement of chorion as a membrane for GTR. The patients were followed for clinical and radiographic parameters and were evaluated between 3 and 6 months after surgery. Result: In intragroup comparison, a significant difference was evident in both the groups for all the clinical and radiographic parameters within the groups. (p = 0.01) This means both amnion and chorion membranes showed statistically significant regenerative efficacy. In intergroup comparison, the results show that all the clinical parameters and radiographic parameters show no significant difference between the groups. Conclusion: The amnion and chorion membranes had similar regenerative efficacy in combination with DFDBA in patients with buccal degree II furcation defects in mandibular molars. Clinical significance: The amnion and chorion membranes have shown significant improvement in clinical and radiographic parameters when used for the treatment of buccal degree II furcation defects in mandibular molars.

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