Amir Moeintaghavi, A. Haerian-Ardakani, Mohammadreza Talebi-Ardakani, I. Tabatabaie
Citation Information :
Moeintaghavi A, Haerian-Ardakani A, Talebi-Ardakani M, Tabatabaie I. Hyperlipidemia in Patients with Periodontitis. J Contemp Dent Pract 2005; 6 (3):78-85.
Periodontitis is a bacterial infection, which has been classified as a local chronic inflammation. This, as well as cardiovascular disease, may share common risk factors such as smoking, diabetes, behavioral factors, aging, and male gender. The aim of this study was to evaluate the association between hyperlipidemia and periodontitis.
Materials & Methods
The levels of plasma lipids in 40 subjects with periodontitis (CPITN score III or IV, pocket depth 4 mm) with mean age 32.3 ±1.2 years were measured and compared with those obtained from 40 age and sex matched controls. Both groups were systemically healthy according to their medical history.
Results
Total cholesterol (CHL) and triglycerides (TG) were significantly higher in the case group (P=0.045 and P=0.016, respectively). HDL and LDL cholesterols were higher in patients but did not have any significant differences with controls. The frequency of persons with pathologic values of TG and CHL were significantly higher in cases compared with controls.
Conclusions
These results showed hyperlipidemia may be associated with periodontitis in healthy people. However, it is unclear whether periodontitis causes an increase in levels of serum lipids or hyperlipidemia is a risk factor for both periodontitis and cardiovascular disease.
Citation
Moeintaghavi A, Haerian-Ardakani A, Talebi-Ardakani M, Tabatabaie I. Hyperlipidemia in Patients with Periodontitis. J Contemp Dent Pract 2005 August;(6)3:078-085.
Plasma lipid and blood glucose levels in patients with destructive periodontal disease. J Clin Periodontol 2000;27:537-541.
Path physiological relationships between periodontitis and systemic disease: recent concepts involving serum lipids. J Periodontol 2000;71:1375-1384.
Association between dental health and acute myocardial infarction. Br Med J 1989;298:779-781.
Missing teeth and ischemic heart disease in men aged 45- 64 years. Euro Heart J 1993;14:54-57.
Dental disease and risk of coronary heart disease and mortality. Br Med J 1993;306:688-691.
Association between acute cerebrovascular ischemia and chronic and recurrent infection. Strok 1997;28:1724-1729.
Periodontitis: a risk factor for coronary heart disease? Ann of Periodontol 1998;3:127-141.
Possible explanation for tooth loss and cardiovascular disease relationship. Ann of Periodontol 1998;3:175-183.
Periodontal diseases contributions to cardiovascular disease: an overview of potential mechanisms. Ann of Periodontol 1998;3:142-150.
Interaction between periodontal disease, Medical disease and immunity in the older individual. Periodontol 2000 1998;16:80-105.
Hyper lipidaemia, atherosclerosis and oral inflammatory disease. Acta Angiologica 1995;1:133-137.
On the association between hypercholesterolemia, cardiovascular disease and sever periodontal disease. J Clin Periodontol 2001;28:865-868.
Periodontal diseases: epidemiology. Ann of Periodontol 1996;1:1-36.
Association between periodontitis and hyperlipidemia: Cause or effect? J Periodontol 1999;70:1429-1434.
Lipids, Lipoproteins and apoproteins in serum during infection. Clin Chem 1986;32:142-145.
Inflammation, dyslipidemia and vascular risk factors in hemodialysis patients. Kidn Int Suppl 1997;62:553-555.
Feingold K R. Effects of tumor necrosis factor administration in vivo on lipoprotein lipase activity in various tissues of the rat. J Lipid Res 1989;30:579-585.
Infection as a risk factor for infarction and atherosclerosis. Ann of Med 1991;23:539-543.
Tumor necrosis Factor alpha stimulates hepatic lipogenesis in the rat in vivo. J Clin Inves 1987;80:184-190.
Stimulation of lipolysis in humans by physiological hyper corticosolemia. Diabetes 1991;40:1228-1232.
Effects of noradrenalin on glycerol turnover and lipolysis in the whole body and subcutaneous adipose tissue in humans in vivo. Clin Sci 1994;86:177-184.
Tumor necrosis factor decreases human adipose tissue lipoprotein lipase mRNA levels, synthesis and activity. J Lipid Res 1989;30:1917-1923.
Triglyceride kinetics, tissue lipoprotein lipase, and liver lipogenesis in septic rats. Am J Phisio 1990;258:678-685.
Endotoxin rapidly induces changes in lipid metabolism that produce hyper triglyceridemia: Low doses stimulate hepatic triglyceride production and inhibit clearance. J Lipid Res 1992;33:1765-1776.
Sepsis and fat metabolism. Br J Sur 1996;83:1186-1196.
Leukocyte and platelet function and eicosanoid production in subjects with hypercholestrolemia. Atherosclerosis 1990; 83:101-108.
Increased generation of reactive Oxygen species in mononuclear cells from hypercholesterolaemic patients. Thrombosis Res 1993;71:237-240.
Aggregation behavior of blood granulocytes in patients with periodontal disease. Arch Oral Bio 1990;35:75-77.
Super oxide formation and chemiluminescence of peripheral polymorphonuclear leukocytes in rapidly progressive periodontitis patients. J Clin Periodontol 1991;18:44-48
Increased release of free oxygen radicals from peripheral neutrophils in adult periodontitis after FC- receptor stimulation. J Clin Periodontol 1996; 23: 38-44.
