The Journal of Contemporary Dental Practice

Register      Login



Volume / Issue

Online First

Related articles

VOLUME 7 , ISSUE 4 ( September, 2006 ) > List of Articles


Dental Development in Subjects with Thalassemia Major

Abdalla M. Hazza'a, Ghaida Al-Jamal

Citation Information : Hazza'a AM, Al-Jamal G. Dental Development in Subjects with Thalassemia Major. J Contemp Dent Pract 2006; 7 (4):63-70.

DOI: 10.5005/jcdp-7-4-63

License: CC BY-NC 3.0

Published Online: 01-02-2008

Copyright Statement:  Copyright © 2006; The Author(s).



The aim of this study was to evaluate the dental development of patients with â-thalassemia major and to compare it with unaffected children.

Methods and Materials

Panoramic radiographs of 44 thalassemic patients taken before the age of 16 years were examined. The subjects consisted of 29 males and 15 females ranging in age from 4.9 to 15.7 (mean = 10.8±2.9) years and 44 controls matched for age and sex. The seven left mandibular permanent teeth, second molar to central incisor, were rated on an eight stage scale using the methods described by Demirjian et al.10 The stage of each tooth was converted to the corresponding numeric value and then all values were added to obtain a dental maturity score which corresponded to a dental age. Dental and chronologic ages were compared using a paired t-test. The relationship between the chronologic age and the amount of delay was also determined.


Thirty-nine patients had a delay in the development of their dentition. The mean developmental dental delay was found to be 1.01 years (p<0.05). The range in delay was from 0.1 to 2.9 years. There was no significant difference between the mean chronologic and dental age of the control group (p> 0.05). The amount of delay in dental development increases as the patient.s age increased (p<0.05). Males were found to have a greater delay (mean 1.16 years) than females (mean delay 0.73 years), but this difference was not statistically significant.


The delay in dental development in β-thalassemia major varied according to the patient.s age. This positive correlation parallels the general growth of thalassemic children.


Hazza.a AM, Al-Jamal G. Dental Development in Subjects with Thalassemia Major. J Contemp Dent Pract 2006 September;(7)4:063-070.

PDF Share
  1. Community control of hereditary anemias. Bull World Health Organ. 1983;61:63-80.
  2. The dental management of children with sickle cell disease and b-thalassaemia: a review. Int J Paed Dent 1996 6:227-234.
  3. The Thalassaemia Syndromes, 3rd ed, Oxford: Blackwell; 1981:132-174.
  4. The thalassemia syndromes: molecular basis and prenatal diagnosis. Semin Hematol 1990;27:209-228.
  5. The pathophysiology and molecular genetics of beta thalassemia. Mt Sinai J Med 1993;60:95-103.
  6. Hormonal changes in thalassemia major. Arch Dis Child 1976;51:828-836.
  7. Bone growth in thalassemic children. Arch Dis Child 1978;53:963-965.
  8. Prevalence of hemoglobin S and beta-thalassemia in northern Jordan. J Obstet Gynaecol Res. 1996;22:17-20.
  9. Prevalence of thalassemia in schoolchildren in north-eastern Badia, Jordan. East Mediterr Health 1999;5:1165-1170.
  10. A new system of dental age assessment. Hum Biol 1973;45:211-227.
  11. Maturation indicators and the pubertal growth spurt. Am J Orthodontics 1982;82:299-309.
  12. Effect of extraction of deciduous molars on the formation and eruption of their successors. Angle Orthod 1962;32:44-53.
  13. Dentistry for children and adolescent. St Louis: CV Mosby;1969.
  14. The effect of premature loss of deciduous molars on premolar eruption. Angle Orthod 1965;35:249-252.
  15. A longitudinal study of tooth formation and root resorption. N Z Dent J 1961;57:202-217.
  16. Étude comparative de la croissance de l.enfant Canadian d.origine française a Montreal. Can J Publ Health 1971;62:111-119.
  17. Dental development of the French Canadian child. J Can Dent Assoc 1971;37:100-104.
  18. The relationship between toothformation and other maturational factors. Angle Orthod 1960;30:70-77.
  19. Age variation of formation stages for ten permanent teeth. J Dent Res 1963;42:1490-1502.
  20. Age of attainment of mineralized stages of the permanent dentition. Forensic Sci 1976;21:191-200.
  21. Dental and oral findings in Cooley.s anemia: a study of fifty cases. Ann NY Acad Sci 1964;119:664-666.
  22. The development of oral and facial signs in ß thalassaemia major. Br Dent J 1988;164:50-51.
  23. The thalassemias: Oral manifestations and complications. Oral Surg Oral Med Oral Pathol 1986;62:229-233.
  24. Bimaxillary hyperplasia: the facial expression of homozygous ß thalassaemia. Oral Surg Oral Med Oral Pathol 1990;69:185-190.
  25. Cephalometric measurements and facial deformities in subjects with ß thalassaemia major. Eur J Orthod 2002;24:9-19.
  26. Thalassaemia: Changes visible in radiographs used in dentistry. Oral Surg Oral Med Oral Pathol 1968 25: 564-576.
  27. Oromaxillofacial changes in thalassemia major. Minerva Pediatr. 1996;48:11-20.
  28. Assessment of Dental and Skeletal Maturity, A New Approach. A comparison of radiographic methods of assessing skeletal and dental maturation, and an evaluation of the correlations among the various maturity indicators in the 8-12 year age. Angle Orthod 1987;57:194-208.
  29. Cephalofacial defotmities in thalassemia major (Cooley.s anemia): A correlative study among 138 cases. Am J Dis Child 1971;121:300-306.
  30. Cooley.s anemia: a review of the roentgenographic findings in the skeleton. Am J Roentg 1957;78:381-391.
  31. Depressed serum somatomedin activity in beta-thalassemia. J Pediatr 1980;96:214-218.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.