The Journal of Contemporary Dental Practice

Register      Login

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue

Online First

Archive
Related articles

VOLUME 8 , ISSUE 5 ( July, 2007 ) > List of Articles

RESEARCH ARTICLE

Periodontal Findings and Blood Analysis of Blood Donors: A Pilot Study

Else Hornecker, Dirk Ziebolz, Gesa C. Jäger, Rainer F. Mausberg

Citation Information : Hornecker E, Ziebolz D, Jäger GC, Mausberg RF. Periodontal Findings and Blood Analysis of Blood Donors: A Pilot Study. J Contemp Dent Pract 2007; 8 (5):43-50.

DOI: 10.5005/jcdp-8-5-43

License: CC BY-NC 3.0

Published Online: 00-07-2007

Copyright Statement:  Copyright © 2007; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Aim

Before blood donation a medical check-up is mandatory to ascertain the health of the donor and to detect infections clinically. Although gingivitis and periodontitis are also bacterial infections, the oral cavity is only inspected superficially. The purpose of this study was to investigate the periodontal condition of blood donors and whether this affects the results of their blood tests.

Methods and Materials

A total of 192 blood donors were examined. The investigation included a periodontal examination to determine the Community Periodontal Index (CPI), an analysis of blood chemistry, as well as the determination of hematologic, coagulation, and immune parameters C-reactive protein (CRP), Neopterin, Procalcitonin (PCT), and tumor necrosis factor (TNF-α). Groups were formed according to periodontal status: “healthy” (n=47, mean age 24±4 years), “gingivitis” (n=65, mean age 24±4 years), and “periodontitis” (n=80, mean age 29±8 years). Most parameters of the routine blood test as well as the immune parameters were unremarkable with regard to the periodontal status. The values for SGPT, GGTP, uric acid, triglycerides, total protein (TP), RBC, hemoglobin (Hb) and hematocrit (HC), Eos, and Baso were also within the normal range. Nevertheless, statistical analysis showed some significant differences in these parameters between the “healthy” group and the “periodontitis” group (p≤0.05).

Results

The results of this study show some blood donors have infections of the gingiva and/or of other periodontal tissues. Whether this is a sufficient reason to exclude them from blood donation, or in which case potential donors should be excluded, is not yet known. Nevertheless, it seems reasonable to integrate a screening method for revealing at least severe periodontitis in the medical check-up of blood donors.

Citation

Ziebolz D, Jäger GC, Hornecker E, Mausberg RF. Periodontal Findings and Blood Analysis of Blood Donors: A Pilot Study. J Contemp Dent Pract 2007 July;(8)5:043-050.


PDF Share
  1. Periodontal conditions in adults, 35-44 years of age: an overview of CPITN data in the WHO global data bank. Community Dent Oral Epidemiol. 1986;14:310-312.
  2. Periodontitis . Chronic Periodontitis. Ann Periodontol. 1999;4:32-38.
  3. Early-Onset Periodontitis. Aggressive Periodontitis. Ann Periodontol. 1999;4:39-53.
  4. Die Pathogenese plaquebedingter Parodontalerkrankungen, in: Klinische Parodontologie; hrsg. v. Lindhe J; Thieme, Stuttgart 1986, p. 125-157.
  5. Nature of periodontal diseases: pathogenic mechanisms. J Periodontal Res. 1987;22:172-178.
  6. The bacterial etiology of destructive periodontal disease: current concepts. J Periodontol. 1992;63:322-331.
  7. Microbial etiology of periodontal disease. J Clin Periodontol. 1981;8:261-280.
  8. The role of inflammatory mediators in the pathogenesis of periodontal disease. J Periodontal Res. 1991;26:320-242.
  9. Entzündungsmechanismen und immunologische Reaktionen in der Gingiva. Dtsch Zahnärztl Z. 1972;28:1166-1169.
  10. Role of the polymorphonuclear leucocyte in periodontal health and disease. J Clin Periodontol. 1984;11:1-15.
  11. Role of the neutrophil in oral disease: receptor deficiency in leukocytes from patients with juvenile periodontitis. Rev Infect Dis. 1985;7:419-425.
  12. Allgemeine und spezielle Pathologie. Thieme, Stuttgart 1989, p. 207-247, p. 405-415.
  13. Tumor necrosis factor. New insights into the molecular mechanisms of multiple actions. J Biol Chem. 1991;266:7313-7316.
  14. Tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta). Curr Opin Immunol. 1992;4:327-323.
  15. Interleukin-6: an Overview. Annu Rev Immunol. 1990;8:253-278.
  16. Neopterin and endogenous interferon gamma in serum of patients with Epstein-Barr virus-associates lymphoproliferative diseases. Transplantation. 1990; 36: 189-191.
  17. Neopterin as a new biochemical marker for diagnosis of allograft rejection. Experience based upon evaluation of 100 consecutive cases. Transplantation. 1983;36:650-653.
  18. Neopertin excretion during incubation period, clinical manifestation and reconvalescence of viral infection. Walter de Gruyter. 1984;3:433-447.
  19. Erhöhte Ausscheidung von Neopterin im Harn von Patienten mit malignen Tumoren und mit Viruserkrankungen. Hoppe-Seylers Z Physiol Chem. 1979;360:1957-1960.
  20. Serum Procalcitonin as an index of inhalation injury in burns. Horm Metab Res. 1992;24:439-442.
  21. Procalcitonin - ein neuer Marker der inflammatorischen Wirtsantwort. Longitudinalstudien bei Patienten mit Sepsis und Peritonitis. Z Gastroenterol. 1995;11:51-54.
  22. ed: World Health Organization, Geneva 1997, p. 36-38.
  23. Evaluating periodontal status of U.S. employed adults. J Am Dent Assoc. 1990;121:226-232.
  24. The .high risk. group in periodontitis. Br Dent J. 1989;167:168-171.
  25. Assessment of risk for periodontal disease. I. Risk indicators for attachment loss. J Periodontol. 1994;65:260-267.
  26. Microcirculation and rheology. Presse Med. 1994;23:213-224.
  27. Der Einfluß der Initialtherapie auf Symptome der Erwachsenen-Parodontitis. Dtsch Zahnärztl Z. 1991;46:370-372.
  28. Acute-phase protein detection and quantification in gingival crevicular fluid by direct and indirect immunodot. J Clin Periodontol. 1991;18:101-106.
  29. Systemic acute phase reactants, C-reactive protein and haptoglobin, in adult periodontitis. Clin Exp Immunol. 1997;107:347-352.
  30. The ability of gingival crevicular fluid phase proteins to distinguish healthy, gingivitis and periodontitis sites. J Clin Periodontol. 1992;19:98-102.
  31. Levels of interleukin-1b in tissue from sites of active periodontal disease. J Clin Periodontol. 1991;18:548-554.
  32. Host response tests for diagnosing periodontal diseases. J Periodontol. 1992;63:356-366.
  33. Levels of cytokines and collagen type I and III as a function of age in human gingivitis. J Periodontol. 1996;67:788-793.
  34. Tumor necrosis factor alpha in gingival crevicular fluid as a possible indicator of periodontal disease in humans. Arch Oral Biol. 1990;35:431-434.
  35. Role of cytokines in the modulation of neutrophil chemotaxis in localized juvenile periodontitis. J Periodontal Res. 1994;29:127-137.
  36. Periodontitis and concentrations of the cellular activation marker neopterin in saliva and urine. Clin Chim Acta. 1997; 268: 31-40.
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.