The Journal of Contemporary Dental Practice

Register      Login

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue

Online First

Archive
Related articles

VOLUME 8 , ISSUE 6 ( September, 2007 ) > List of Articles

RESEARCH ARTICLE

A Comparative Evaluation of the Effectiveness of an Anorganic Bone Matrix/Cell Binding Peptide with an Open Flap Debridement in Human Infrabony Defects: A Clinical and Radiographic Study

Manohar L. Bhongade, Ishan R. Tiwari

Citation Information : Bhongade ML, Tiwari IR. A Comparative Evaluation of the Effectiveness of an Anorganic Bone Matrix/Cell Binding Peptide with an Open Flap Debridement in Human Infrabony Defects: A Clinical and Radiographic Study. J Contemp Dent Pract 2007; 8 (6):25-34.

DOI: 10.5005/jcdp-8-6-25

License: CC BY-NC 3.0

Published Online: 00-09-2007

Copyright Statement:  Copyright © 2007; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Aim

The development of biologic modalities designed to enhance bone regeneration and wound healing of specific periodontal sites continues to unfold. This is accomplished through the cell binding activity of Type-I collagen provided by a synthetic cell binding peptide (P-15) which is incorporated in a scaffold of anorganic bovine matrix (ABM). This combination is designed to facilitate the attachment, migration, and differentiation of cells. The objective of this study is to clinically and radiographically evaluate the effectiveness of the combination of ABM and P-15 (ABM/P-15) ‘putty’ during regenerative periodontal procedures.

Methods and Materials

A total of 20 interproximal intraosseous defects in 16 patients, (8 males, 8 females), age 22-48 years (mean 34.45) were recruited and divided equally into two experimental groups. Following open flap debridement (OFD), the defect sites in a test group were grafted with a bovine-derived xenograft enriched with a cell binding peptide. The defect sites in a control group were treated with only OFD. Appropriate periodontal maintenance schedules were followed; at six months, clinical and radiographic assessments for soft tissue and hard tissue were performed for documentation and finalization of results.

Results

Statistical analysis using student paired ‘t’ test analyses of the patient mean value from the 16 patients revealed the ABM/P-15 ‘putty’ graft group demonstrated significantly better mean defect fill of 3.4 + 0.7 mm (70.5%) versus mean defect fill of 0.9 mm (17.33%) for defects treated with only OFD. Soft tissue findings showed significant differences among treatment with ABM/P-15 compared to OFD.

Conclusions

These results indicate the use of P-15 synthetic cell binding peptide combined with ABM yields better clinical results in conjunction with OFD than with OFD alone.

Citation

Bhongade ML, Tiwari IR. A Comparative Evaluation of the Effectiveness of an Anorganic Bone Matrix/ Cell Binding Peptide with an Open Flap Debridement in Human Infrabony Defects: A Clinical and Radiographic Study. J Contemp Dent Pract 2007 September; (8)6:025-034.


PDF Share
  1. Thirty-six months follow-up of 25 patients treated with combination anorganic bovine-derived hydroxyapatite matrix (ABM)/cell binding peptide (P-15) bone replacement grafts in human intrabony defects. I. Clinical findings. J Periodontol 2002;73:123-128.
  2. An experimental study of new attachment procedure in beagle dogs. J Periodontal Res 1983;18:643-654.
  3. A six month clinical evaluation of decalcified freezedried bone allograft in periodontal osseous defects. J Periodontol 1982;53:726-730.
  4. A comparison of freeze-dried bone allograft and decalcified freeze-dried bone allograft in human periodontal osseous defects. J Periodontol 1989;60:665-663.
  5. Osseous defect responses to hydroxyapatite grafting versus open flap debridement. J Clin Periodontol 1989;16:398-402.
  6. Histological comparison of healing extraction sockets implanted with bioactive glass or demineralized freeze-dried bone allograft: A pilot study. J Periodontol 2002;73:94-102.
  7. Clinical evaluation of bioactive glass in the treatment of periodontal defects in humans. J Periodontol 1998;69:027-1035.
  8. Regulation of bone cell metabolism. J Oral Pathol Med 1989;18:344-351.
  9. A combination of platelet-derived and insulin-like growth factors enhances periodontal regeneration. J Clin Periodontol 1989;16:545-548.
  10. Osteoinduction: A report on the discovery and research of unique protein growth factors mediating bone development. Oral Surg Oral Med Oral Pathol 1989;68:527-530.
  11. Design of boimimetic habitats for tissue engineering with P-15, a synthetic peptide analog of collagen. Tissue Eng 1999;5:53-65.
  12. The putative collagen binding peptide hastens periodontal ligament cell attachment to bone replacement graft materials. J Periodontol 2001;72:990-997.
  13. Periodontal regeneration following use of ABM/P-15: A case report. Int J Periodontics Restorative Dent 2002;22:146-155.
  14. Small Peptide (P-15) bone substitute efficacy in a rabbit cancellous bone model. 2005: Paper # 0212, 51 st Annual Meeting of Orthopaedic Research Society.
  15. Multi-center clinical evaluation of combination anorganic bovine-derived hydroxyapatite matrix (ABM)/ cell binding peptide (P-15) as a bone replacement graft material in human periodontal osseous defects. 6-month results. J Periodontol 1998;69:655-663.
  16. Multi-center clinical comparison of combination anorganic bovine-derived hydroxyapatite matrix (ABM)/cell binding peptide (P-15) and ABM in human periodontal osseous defects. 6-month results. J Periodontol 2000;71:1671-1679.
  17. Periodontal disease in pregnancy (II). Correlation between oral hygiene and periodontal condition. Acta Odontologica Scandinavica 1964;22:121-135.
  18. Periodontal disease in pregnancy (I). Prevalence and severity. Acta Odontologica Scandinavica 1963;21:533-551.
  19. Methods in Biostatistics. Ed 5. New Delhi, Jaypee Brothers. 1991:128-153.
  20. Comparative clinical evaluation of combination anorganic bovinederived hydroxyapatite matrix (ABM)/cell binding peptide (P-15) and open flap debridement (DEBR) in human periodontal osseous defects: A 6-month pilot study. J Int Acad Periodontol 2004;6/3: 101-107.
  21. Periodontal regeneration of human infrabony defects. (V) Effects of oral hygiene on long term stability. J Clin Periodontol 1994; 21:606-610.
  22. Bone regeneration of localized chronic alveolar defects utilizing cell binding peptide associated with anorganic bovinederived bone mineral: a clinical and histological study. J Periodontol 2002;73:1153-1159.
  23. Periodontal regeneration with peptide-enhanced anorganic bone matrix in particulate and putty form in dogs. J Periodontol 2005; 76: 1690-1696.
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.