The Journal of Contemporary Dental Practice

Register      Login

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue

Online First

Archive
Volume  25 (2024)
Volume  24 (2023)
Volume  23 (2022)
Volume  22 (2021)
Volume  21 (2020)
Volume  20 (2019)
Volume  19 (2018)
Volume  18 (2017)
Volume  17 (2016)
Volume  16 (2015)
Volume  15 (2014)
Volume  14 (2013)
Volume  13 (2012)
Volume  12 (2011)
Volume  11 (2010)
Volume  10 (2009)
Volume  9 (2008)
Volume  8 (2007)
Volume  7 (2006)
Volume  6 (2005)
Volume  5 (2004)
Volume  4 (2003)
Volume  3 (2002)
Volume  2 (2001)
Volume  1 (1999)
Related articles

VOLUME 14 , ISSUE 2 ( March-April, 2013 ) > List of Articles

RESEARCH ARTICLE

Effect of Periodontal Therapy on Serum C-Reactive Protein Levels in Patients with Gingivitis and Chronic Periodontitis: A Clinicobiochemical Study

Veena A Patil, Manthan H Desai

Citation Information : Patil VA, Desai MH. Effect of Periodontal Therapy on Serum C-Reactive Protein Levels in Patients with Gingivitis and Chronic Periodontitis: A Clinicobiochemical Study. J Contemp Dent Pract 2013; 14 (2):233-237.

DOI: 10.5005/jp-journals-10024-1305

Published Online: 01-08-2013

Copyright Statement:  Copyright © 2013; The Author(s).


Abstract

Aim

The aim of the present study was to evaluate the effect of periodontal therapy on serum C-reactive protein (CRP) levels in patients with gingivitis and chronic periodontitis.

Materials and methods

A total of 60 subjects (30 males and 30 females) were included in the study with 20 subjects in each of the groups classified based on community periodontal index (CPI) scores: I: Healthy, II: Gingivitis, III: Mild periodontitis. Periodontal therapy was performed on groups II and III patients. Venous blood was collected from each subject at baseline and 3 months after periodontal therapy. The collected sample was subjected to biochemical analysis to detect CRP levels by using immunoturbidimetric method.

Results

The present study demonstrated that the periodontitis group had a higher mean CRP levels (2.49 ± 0.47 ng/ml) as compared to the gingivitis group (1.40 ± 0.32 ng/ml) and healthy group (0.56 ± 0.20 ng/ml). The mean CRP values after periodontal therapy were found to be reduced to 0.44 ± 0.23 ng/ml in group II and 1.30 ± 0.36 ng/ml in group III patients.

Conclusion

Within the limitations of this study, it can be concluded that CRP level progressively increases from periodontal health to disease. A decrease in CRP levels with periodontal treatment was also observed.

Clinical significance

Due to its opsonizing abilities CRP plays an important role in the innate host defence. It can be hypothesized that CRP is a potential biomarker of periodontal disease. A number of studies have reported elevated serum CRP levels in periodontitis subjects. Long standing periodontal disease and raised CRP levels enhance the risk of cardiovascular disease, cerebrovascular accidents and preterm low birth weight infants. There is also evidence that effective periodontal therapy can lower serum CRP levels. However, the data of interventional studies on CRP in gingivitis and periodontitis is scarce.

How to cite this article

Patil VA, Desai MH. Effect of Periodontal Therapy on Serum C-Reactive Protein Levels in Patients with Gingivitis and Chronic Periodontitis: A Clinicobiochemical Study. J Contemp Dent Pract 2013;14(2):233-237.

PDF Share
  1. Carranza's clinical periodontology (9th ed). Noida: Saunders: Reed Elsevier India Private Limited 1996:67.
  2. Acute-phase reactants in infections and inflammatory diseases. Periodontol 2000, 2000;23:19-49.
  3. Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease: Meta-analyses of prospective studies. JAMA 1998;279:1477-82.
  4. The relationship between infection, inflammation, and cardiovascular disease: An overview. Ann Periodontol 2001;6:1-8.
  5. Cytokines and the hepatic acute-phase response. J Pathol 1997;181:257-66.
  6. Serological reactions in pneumonia with a non-protein somatic fraction of pneumococcus. J Exper Med 1930;52:561-71.
  7. A systematic review and meta-analyses on CRP in relation to periodontitis. J Clin Periodontol 2008;35(4):277-90.
  8. Periodontal diseases. Lancet 2005;366:1809-20.
  9. The role of inflammatory mediators in the pathogenesis of periodontal disease. J Periodontal Res 1991;26:230-42.
  10. C-reactive protein: A critical update. J Clin Invest 2003;111:1805-12.
  11. Re-evaluation of initial therapy: When is the appropriate time? J Periodontol 2006;77(9): 1598-601.
  12. Effect of nonsurgical periodontal therapy. III. Single versus repeated instrumentation. J Clin Periodontol 1984;11(2):114-24.
  13. Systemic acute-phase reactants, C-reactive protein and haptoglobin, in adult periodontitis. Clin Exp Immunol 1997;107(2):347-52.
  14. Systemic effects of periodontitis. Ann R Australas Coll Dent Surg 2006;18:27-29.
  15. Relationship of destructive periodontal disease to the acutephase response. J Periodontol 2003;74(7):1007-16.
  16. Heterogeneity of systemic inflammatory responses to periodontal therapy. J Clin Periodontol 2009;36(4):287-94.
  17. Periodontitis and systemic inflammation: Control of the local infection is associated with a reduction in serum inflammatory markers. J Dent Res 2004;83:156-60.
  18. Effect of periodontal treatment on serum C-reactive protein levels: A systematic review and meta-analysis. J Periodontol 2006;77(10):1635-42.
  19. Evaluation of gingival crevicular fluid and serum levels of high sensitivity C-reactive protein in chronic periodontitis patients with or without coronary artery disease. J Periodontol 2007;78:2319-24.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.