The Journal of Contemporary Dental Practice

Register      Login

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue

Online First

Archive
Volume  25 (2024)
Volume  24 (2023)
Volume  23 (2022)
Volume  22 (2021)
Volume  21 (2020)
Volume  20 (2019)
Volume  19 (2018)
Volume  18 (2017)
Volume  17 (2016)
Volume  16 (2015)
Volume  15 (2014)
Volume  14 (2013)
Volume  13 (2012)
Volume  12 (2011)
Volume  11 (2010)
Volume  10 (2009)
Volume  9 (2008)
Volume  8 (2007)
Volume  7 (2006)
Volume  6 (2005)
Volume  5 (2004)
Volume  4 (2003)
Volume  3 (2002)
Volume  2 (2001)
Volume  1 (1999)
Related articles

VOLUME 14 , ISSUE 3 ( May-June, 2013 ) > List of Articles

RESEARCH ARTICLE

A Double Blind Study on the Efficacy of Local Application of Hemocoagulase Solution in Wound Healing

PG Francis, BHS Rao, M Ummar, JK Issac, RB Nair

Citation Information : Francis P, Rao B, Ummar M, Issac J, Nair R. A Double Blind Study on the Efficacy of Local Application of Hemocoagulase Solution in Wound Healing. J Contemp Dent Pract 2013; 14 (3):394-400.

DOI: 10.5005/jp-journals-10024-1334

Published Online: 01-10-2013

Copyright Statement:  Copyright © 2013; The Author(s).


Abstract

Aim

The present double blind study has been designed to evaluate the efficacy of local application of hemocoagulase solution as compared to a placebo in wound healing following dental extraction.

Materials and methods

A total of 20 patients who required dental extraction for orthodontic intervention were included. The hemocoagulase solution and a placebo were locally applied to the extraction sockets and the efficacy of the solution in terms of bleeding control, anti-inflammatory responses, its antiseptic properties and efficacy in wound healing were evaluated.

Results

The mean time required to achieve hemostasis was found to be 1.37 minutes in side A (test) and 2.33 minutes in side B (control) indicating that side A achieved faster hemostasis when compared to side B. At the 6th hour postoperatively, bleeding was not evident on either sides, and the amount of pain in side A was found to be less compared to side B. The number of RBCs, polymorphs, chronic inflammatory cells were not different in both the groups, whereas at 3rd postoperative day epithelial cells were greater in side A (test) compared to side B (control). Biopsy reports on the 12th postoperative day indicated that the number of fibroblasts, epithelial cells, collagen count was found to be greater in side A (test) compared to side B (control).

Conclusion

The topical hemocoagulase solution may be advocated in the field of oral and maxillofacial surgery, as a hemostatic agent and promoter of wound healing. However, further studies, with large number of cases and different clinical situations should be considered to authenticate the efficacy of this hemocoagulase solution in the practice of oral and maxillofacial surgery.

Clinical significance

Wound healing plays an important role in the success of any surgical procedure, such as extractions, and the hemocoagulase system may act as a hemostatic agent and a promoter of wound healing.

How to cite this article

Aslam S, Francis PG, Rao BHS, Ummar M, Issac JK, Nair RB. A Double Blind Study on the Efficacy of Local Application of Hemocoagulase Solution in Wound Healing. J Contemp Dent Pract 2013;14(3):394-400.

PDF Share
  1. Effects of procoagulants on wound healing. Indian J Exp Biol 1990;28(1):43-45.
  2. Healing of oral wounds. A text book of oral pathology, 4th ed. WB Saunders Company 1993:594-595.
  3. Thrombin-like and factor X-activator components of Bothrops snake Venoms. Thrombos Haemostas 1979;41:314-327.
  4. Coagulation processes and ophidic venoms. Toxicon 1955;6:30-35.
  5. Clinical applications of fibrin sealants. J Oral Maxillofac Surg 2004;62(2):218-224.
  6. Employment of Bothrops jararaca venom as coagulant in ENT surgery. Latin Am Otorhinolaryngol Min 1957;1-10.
  7. Effects of Botropase on wound healing. Ind J Surg 1990 May;52(5):218-221.
  8. Trial of some hemostatic drugs in tonsillectomy under general anesthesia with intubation. Minerva Med 1968;59(93):5011-5014.
  9. Hemostasis is a shared responsibility. J Oral Maxillofac Surg 2003;61:1377-1378.
  10. Hemostatic effect of n-butylol–2– cyanoacrylate glue in warfarin-treated patients undergoing oral surgery. J Oral Maxillofac Surg 2003;61(12):1405-1409.
  11. Biochemical and pharmacological screening of snake (Bothrops) venoms: characterization of components acting on blood coagulation and platelet aggregation. Braz J Med Biol Res 1988;21(4):763-765.
  12. Intraocular infusate with hemocoagulase for the control of bleeding during vitreous surgery. Korian J Ophthalmol 1989 June;3(1):6-10.
  13. Clinical trial on the efficacy of hemocoagulant (Botropase) in coagulation. J Otolaryngol (Bihar) 1982;3:2.
  14. Targeting exosites on blood coagulation proteases. An Acad Bras Cienc 2005 Jun;77(2):275-280.
  15. Action of snake Bothrops jararaca venom in the treatment of ophthalmic zona. Minerva Oftalmol 1969 Mar-Apr;11(2):43-47.
  16. Action of snake venom components on the hemostatic system. Blood Rev 1993 Sept;7(3):176-189.
  17. Snake venoms affecting the hemostatic mechanism: a consideration of their mechanisms, practical applications and biological significance. Blood Coagul Fibrinolysis 1994 June;5(3):399-410.
  18. Snake venoms and the hemostatic system. Toxicon 1998 Dec;36(12):1749-1800.
  19. Snake venom proteases affecting hemostasis and thrombosis. Biochem Biophys Acta 2000 March;1477(1-2):146-156.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.