The Journal of Contemporary Dental Practice

Register      Login

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue

Online First

Archive
Related articles

VOLUME 14 , ISSUE 6 ( November-December, 2013 ) > List of Articles

CASE REPORT

Calcifying Odontogenic Cyst: A Rare Report of A Nonneoplastic Variant associated with Cholesterol Granuloma

Manikkath Aparna, Mukund Gupta, Abhay Kamath, Monica Solomon, Keerthilatha Pai, Raghu Radhakrishnan

Citation Information : Aparna M, Gupta M, Kamath A, Solomon M, Pai K, Radhakrishnan R. Calcifying Odontogenic Cyst: A Rare Report of A Nonneoplastic Variant associated with Cholesterol Granuloma. J Contemp Dent Pract 2013; 14 (6):1178-1182.

DOI: 10.5005/jp-journals-10024-1472

Published Online: 01-06-2014

Copyright Statement:  Copyright © 2013; The Author(s).


Abstract

Aim

To report a case of a non-neoplastic variant of calcifying odontogenic cyst (COC) with the lining epithelium showing ameloblastomatous proliferation and capsule exhibiting features of a cholesterol granuloma. The importance of delineating this histologic variant from unicystic ameloblastoma and the formation of cholesterol granuloma in this variant is discussed.

Background

Calcifying odontogenic cyst is a developmental jaw cyst, which presents itself as both the neoplastic and the non-neoplastic forms. The ameloblastomatous variant of COC is often mistaken for unicystic ameloblastoma and treated aggressively.

Case report

A 68-year-old female who presented with a cystic enlargement of the posterior mandible on the right side was suggestive of unicystic ameloblastoma based on radiography and initial biopsy report. Microscopic examination of the excision specimen, however, was fitting in favor of calcifying odontogenic cyst with ameloblastomatous proliferation.

Conclusion

Identifying the non-neoplastic ameloblastomatous variant of COC from a cystic ameloblastoma is crucial as the treatment of the two lesions vary considerably.

Clinical significance

This case emphasizes the need for thorough examination of the entire surgical specimen before arriving at an appropriate diagnosis.

How to cite this article

Aparna M, Gupta M, Sujir N, Kamath A, Solomon M, Pai K, Radhakrishnan R. Calcifying Odontogenic Cyst: A Rare Report of a Nonneoplastic Variant associated with Cholesterol Granuloma. J Contemp Dent Pract 2013;14(6):1178- 1182.


PDF Share
  1. The calcifying odontogenic cyst: a possible analogue of the cutaneous calcifying epithelioma of Malherbe. An analysis of fifteen cases. Oral Surg Oral Med Oral Pathol 1962;15:1235-1243.
  2. Ameloblastoma arising in calcifying odontogenic cyst. Report of a case. Oral Surg Oral Med Oral Pathol 1992;74:776-779.
  3. Histopathologic study of epithelial components in the connective tissue wall of unilocular type of calcifying odontogenic cyst. J Oral Pathol Med 1990;19:108-113.
  4. Ameloblastomatous Gorlin's cyst. J Oral Sci 2007;49:319-323.
  5. Calcifying odontogenic cyst: clinicopathological features and immunohistochemical profile of 10 cases. J Oral Pathol Med 2003;32:163-70.
  6. Ameloblastomatous calcifying odontogenic cyst in the mandible. Dentomaxillofac Radiol 2004;33:409-412.
  7. Ameloblastomatous calcifying odontogenic cyst: a rare histologic variant. J Oral Pathol Med 2003;32:376-378.
  8. Calcifying odontogenic cyst. A review of 92 cases with reevaluation of their nature as cysts or neoplasms, the nature of ghost cells, and subclassification. Oral Surg Oral Med Oral Pathol 1991;72:56-64.
  9. The ultrastructure of cholesterol granuloma of the middle ear: an electron microscope study. The Journal of Laryngology and Otology 1979;93:433-442.
  10. Cholesterol granuloma of the maxillary sinus. Arch Pathol Lab Med 2002;126:217-219.
  11. Basement membrane-type heparan sulfate proteoglycan (perlecan) and low-density lipoprotein (LDL) are colocalized in granulation tissues: a possible pathogenesis of cholesterol granulomas in jaw cysts. J Oral Pathol Med 2004;33:177-184.
  12. Cholesterol crystals as an etiological factor in non-resolving chronic inflammation: an experimental study in guinea pigs. Eur J Oral Sci 1998;106:644-650.
  13. Combined benign odontogenic tumors: CT and MR findings and Histomorphologic Evaluation. Am J Neuroradiol 2001;22:867-872.
  14. Cystic ameloblastoma-behavior and treatment of 21 cases. J Oral Maxillofac Surg 2001;59:1311-1316.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.