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VOLUME 19 , ISSUE 11 ( November, 2018 ) > List of Articles


‘Third Space’ Perspective on Redefining Oral Pathology: Hypothetical Considerations

Barnali Majumdar

Keywords : Interstitium, Oral cancer, Oral pathology

Citation Information : Majumdar B. ‘Third Space’ Perspective on Redefining Oral Pathology: Hypothetical Considerations. J Contemp Dent Pract 2018; 19 (11):1293-1294.

DOI: 10.5005/jp-journals-10024-2420

License: CC BY-NC 4.0

Published Online: 01-02-2019

Copyright Statement:  Copyright © 2018; The Author(s).


Recent molecular analysis has shown the evidences which claims human interstitum as a new organ in the body. However, in routine hematoxylin and eosin stained sections these spaces are not evident and thus probably has not received much attention. The implications of this discovery in oral pathology, especially cancer metastasis are immense. Although the structure and components of oral mucosa differ from that of skin and gastrointestinal tract (GIT) in various aspects, if the above findings are established in the oral submucosa, various oral diseases related to fluid and fluid dynamics may perhaps be reviewed. In this editorial, we have made attempt to hypothetically consider the various possible implications of ‘third space’ in the field of dentistry.

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  1. Benias PC, Wells RG, Sackey-Aboagye B, Klavan H, Reidy J, Buonocore D, Miranda M, Kornacki S, Wayne M, Carr- Locke DL, Theise ND. Structure and Distribution of an Unrecognized Interstitium in Human Tissues. Sci Rep 2018;8(1):4947.
  2. Jacob M, Chappell D, Rehm M. The ‘third space’–fact or fiction? Best practice & research. Clin Anaesth 2009;23(2):145-157.
  3. Nanci A. Ten Cate's Oral Histology E-Book: Development, Structure, and Function. 8th Edition. India: Elsevier; 2012.
  4. Lydiatt WM, Patel SG, O'Sullivan B, Brandwein MS, Ridge JA, Migliacci JC, et al. Head and neck cancers—major changes in the American Joint Committee on cancer eighth edition cancer staging manual. CA: a cancer journal for clinicians. 2017;67(2):122-137.
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