Citation Information :
Kapadia JM, Ganti S, Shriram P, Ansari AS, Azad A, Dubey A. Evaluation of Effect of Glucosamine-Chondroitin Sulfate, Tramadol, and Sodium Hyaluronic Acid on Expression of Cytokine Levels in Internal Derangement of Temporomandibular Joint. J Contemp Dent Pract 2018; 19 (12):1502-1506.
Aim: Evaluation of the effect of glucosamine-chondroitin combination, tramadol, and sodium hyaluronic acid in temporomandibular joint (TMJ) disorders and its impact on the expression of various cytokines such as IL-6, IL-1s, TNF-ƒ¿, and PGE2.
Materials and methods: The present study was conducted on 60 patients (males.30, females.30) suffering from internal derangement such as disc displacement with reduction of TMJ. The patients were divided into three groups of 20 each. Group I received a combination of 1.5g of glucosamine and 1.2 g of chondroitin sulfate per day and group II received 50 mg tramadol HCL peroral. Group III received sodium hyaluronate 10 mg/mL, 2 mL injection syringe on each joint. Pain (VAS) scale and maximum mouth opening (MMO) was measured. The level of IL-6, IL-1s, TNF-ƒ¿, and PGE2 levels were measured using Enzyme-linked immuno sorbent assay (ELISA).
Results: There was an improvement in maximum mouth opening in all three groups (p < 0.05). There was a reduction in pain in all groups. IL- 1 s, TNF-ƒ¿, and PGE2 leve ls showed reduction while IL-6 showed an increase in value in group II and III.
Conclusion: The efficacy of glucosamine chondroitin sulfate, tramadol and hyaluronic acid in TMJ disorders has been found to be effective.
Clinical significance: IL-6, IL-1s, TNF-ƒ¿, and PGE2 levels indicate the risk of TMJ disorders. Thus earlier assessment of their levels helps in diagnosis, and better management may be done.
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