Citation Information :
Gupta A, Abidullah M, Bhuvinder S, Katragadda P. Role of E-cadherin in Progression of Oral Squamous Cell Carcinoma: A Retrospective Immunohistochemical Study. J Contemp Dent Pract 2018; 19 (9):1105-1110.
Aim: The aim of present study was to assess the role of E-cadherin in oral carcinogenesis by comparing their expressions in normal oral mucosa, oral epithelial dysplasia (OED), and oral squamous cell carcinoma (OSCC).
Materials and methods: To elucidate the pattern of E-cadherin expression in oral carcinogenesis, 21 archival cases of formalinfixed paraffin-embedded sections of OSCC, 21 OED, and 7 normal oral mucosa samples as control were used for the study.
Results: We observed reduction/loss of E-cadherin in membranous expression pattern and staining intensity with progression from dysplasia to oral cancer.
Conclusion: A decrease in staining intensity and loss of E-cadherin membranous expression were noted from dysplasia to carcinoma, suggesting its role as a tumor suppressor gene.
Clinical significance: E-cadherin can be used as a biomarker to assess and evaluate the progression and prognosis of oral dysplastic lesions and OSCC.
Diniz-Freitas M, Garcia-Caballero T, Antunez-Lopez J, Gandara-Rey JM. Loss of expression of E-cadherin correlates with increased invasiveness, metastasis and unfavourable prognosis. Oral Oncol 2006;49:190-200.
Cavallaro U, Dejana E. Adhesion molecules signaling: not always a sticky business. Nat Rev Mol Cell Biol 2011 Mar;12(3):189-197.
von Zeidler SV, de Souza Botelho T, Mendonca EF, Batista AC. E-cadherin as a potential biomarker of malignant transformation in oral leukoplakia: a retrospective cohort study. BMC Cancer 2014 Dec;14:972.
Yogesh T, Narayan T, Shreedhar B, Shashidara R, Leekymohanty. The expression of E-cadherin and cathepsin- D in normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma: a comparative analysis between immunohistochemistry and routine histo- pathology. J Oral Maxillofac Pathol 2011 Sep;15(3):288-294.
Christofori G. Semb H. The role of cell-adhesion molecule E-cadherin as a tumour-suppressor gene. Trends Biochem Sci 1999 Feb;24(2):73-76.
Branes L, Eveson JW, Reichert P, Sidransky D. Tumours of the oral cavity and oropharynx. Pathol Genet 2005;67: 177-179.
Doshi Neena P, Shah Siddharth A, Patel Keyuri B, Jhabuawala Munira F. Histological grading of oral cancer: a comparison of different systems and their relation to lymph node metastasis. Natl J Community Med 2011;2(1):136-143.
Zhang W, Alt-Holland A, Margulia A, Shamis Y, Fusenig NE, Rodeck U, Garlick JA: E-cadherin loss promotes the initiation of squamous cell carcinoma invasion through modulation of integrin-mediated adhesion. J Cell Sci 2006;119:283-291.
Bankfalvi A, Krassort M, Vegh A, Felszeghy E, Piffko J. Deranged expression of the E-cadherin/beta-catenin complex and the epidermal growth factor receptor in the clinical evolution and progression of oral squamous cell carcinomas. J Oral Pathol Med 2002 Sep;31(8):450-457.
Wheelock MJ, Shintani Y, Maeda M, Fukumoto Y, Johnson KR. Cadherin switching. J Cell Sci 2008 Mar;121(Pt 6):727-732.
Williams HK, Sanders DS, Jankowski JA, Landini G, Brown AM. Expression of cadherins and catenins in oral epithelial dysplasia and squamous cell carcinoma. J Oral Pathol Med 1998 Aug;27(7):308-317.
Kaur G, Carnelio S, Rao N, Rao L. Expression of E-cadherin in primary oral squamous cell carcinoma and metastatic lymph nodes: an immunohistochemical study. Indian J Dent Res 2009 Jan-Mar;20(1):71-76.
Califano J, van der Riet P, Westra W, Nawroz H, Clayman G, Piantadosi S, Corio R, Lee D, Greenberg B, Koch W, et al. Genetic progression model for head and neck cancer: implications for field cancerization. Cancer Res 1996 Jun;56(11):2488-2492.
Santos-García A, Abad-Hernández MM, Fonseca-Sánchez E, Julián-González R, Galindo-Villardón P, Cruz-Hernández JJ, Bullón-Sopelana A. E-cadherin, laminin and collagen IV expression in the evolution from dysplasia to oral squamous cell carcinoma. Med Oral Pathol Cir Buccal 2006 Mar;11(2): E100-E105.
Mehendiratta M, Solomon MC, Boaz K, Guddattu V, Mohindra A. Clinico-pathological correlation of E-cadherin expression at the invasive tumor front of Indian oral squamous cell carcinomas: an immunohistochemical study. 2014 May;18(2):217-222.
Hung KF, Chang CS, Liu CJ, Lui MT, Cheng CY, Kao SY. Differential expression of E-expression in metastatic lesions comparing to primary oral squamous cell carcinoma. J Oral Pathol Med 2006 Nov;35(10):589-594.
Sorcher SM, Russack V, Cagle M, Feramisco JR, Green MR. Immunolocalization of E-cadherin in human head and neck cancer. Arch Pathol Lab Med 1995 Jan;119(1):82-84.