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VOLUME 20 , ISSUE 12 ( December, 2019 ) > List of Articles


Effectiveness of Controlled Release Chlorhexidine Chip as an Adjunctive to Scaling and Root Planning for the Treatment of Chronic Periodontitis

Rashmi Gupta, Preetinder Singh, Yashpaul Dev, Shipra Sardana, Kirti Rathee, Mallika Sethi

Keywords : Chlorhexidine, Periochip, Scaling and root planning

Citation Information : Gupta R, Singh P, Dev Y, Sardana S, Rathee K, Sethi M. Effectiveness of Controlled Release Chlorhexidine Chip as an Adjunctive to Scaling and Root Planning for the Treatment of Chronic Periodontitis. J Contemp Dent Pract 2019; 20 (12):1402-1405.

DOI: 10.5005/jp-journals-10024-2679

License: CC BY-NC 4.0

Published Online: 01-12-2015

Copyright Statement:  Copyright © 2019; The Author(s).


Background: Chlorhexidine is considered one of the options for the management of periodontal diseases. This present study was conducted to assess the usefulness of controlled-release chlorhexidine chip in addition to scaling and root planning (SRP) while comparing with SRP alone in the treatment of chronic periodontitis clinically, microbiologically and radiographically. Materials and methods: This study included 20 patients age ranged from 30 to 55 years with chronic periodontitis. A total of 40 sites were selected. Two bilateral pockets with probing depth 4–6 mm were put in test and control groups in all subjects. SRP plus Periochip™ was used in the test group and SRP alone in the control group. In all subjects, all the analysis such as clinical parameters, the radiographic and anaerobic culture of P. gingivalis, T. denticola, and T. forsythia were performed and compared in both groups at baseline and 3 months interval. Results: There was a significant improvement in all clinical and radiographic parameters in the test group in comparison to control group. Total colony counts also reduced significantly. At baseline, Tf was recovered from 15 test group sites and 16 control group sites, Pg from 14 test group and 14 control group sites, Td from 16 test group and 15 control group sites. At 3 months, Tf was recovered from 4 test group and 10 control group sites, Pg from 3 test group and 9 control group sites, Td from 4 test group and 8 control group site. Conclusion: Periochip™ placement as an adjunct to SRP, showed promising results when compared to SRP alone. Clinical significance: Periochip is considered the best treatment option in the treatment of chronic periodontitis.

  1. Periodontitis. Glossary of Periodontal Terms: American Academy of Periodontology; 2001. p. 40.
  2. Rams TE, Slots J. Local delivery of antimicrobial agents in the periodontal pocket. Periodontal 2000 1996;10:139–159. DOI: 10.1111/j.1600-0757.1996.tb00072.x.
  3. Marsh PD. Dental plaque: Biological significance of a biofilm and community lifestyle. J Clin Periodontol 2005;32:7–15. DOI: 10.1111/j.1600-051X.2005.00790.x.
  4. Slots J, Rams TE, Listgarten MA. Yeasts, Enteric rods and pseudomonas in the subgingival flora of severe adult periodontitis. Oral Microbial Immunol 1988;3:47–52. DOI: 10.1111/j.1399-302X.1988.tb00080.x.
  5. Listgarten MA. The structure of dental plaque. Periodontol 2000 1994;5:52–65. DOI: 10.1111/j.1600-0757.1994.tb00018.x.
  6. Bruce LP, William FA. Treatment of gingivitis and periodontitis (position paper). J Periodontol 1997;68:1246–1253.
  7. Cobb CM. Non surgical pocket therapy-mechanical. Ann Periodontal 1996;1:443–490. DOI: 10.1902/annals.1996.1.1.443.
  8. Donald A. Consensus report: Non surgical pocket therapy: Pharmacotherapeutics and dental occlusion. Ann Periodontol 1996;1:581–588. DOI: 10.1902/annals.1996.1.1.581.
  9. Mandel ID. Chemotherapeutic agents for controlling plaque and gingivitis. J Clin Periodontol 1988;15:488–498. DOI: 10.1111/j.1600-051X.1988.tb01020.x.
  10. Stabholz A, Sela MN, Friedman M, et al. Clinical and microbiological effects of sustained release chlorhexidine in periodontal pockets. J Clin Periodontol 1986;13:783–788. DOI: 10.1111/j.1600-051X.1986.tb00882.x.
  11. Slots J. Selection of antimicrobial agents in periodontal therapy. J Periodontal Res 2002;37:389–398. DOI: 10.1034/j.1600-0765.2002.00004.x.
  12. Ryan ME. Nonsurgical approaches for the treatment of periodontal diseases. Dent Clin North Am 2005;49:611–636. DOI: 10.1016/j.cden.2005.03.010.
  13. Chaturvedi TP, Srivastava R, Srivastava AK, et al. Evaluation of metronidazole nanofibers in patients with chronic periodontitis: a clinical study. Int J Pharm Investig 2012;2:213–217. DOI: 10.4103/2230-973X.107007.
  14. Cosyn J, Wyn I. A Systematic Review on the Effects of the Chlorhexidine Chip When Used as an Adjunct to Scaling and Root Planing in the Treatment of Chronic Periodontitis. J Periodontol 2006;77:257–264. DOI: 10.1902/jop.2006.050216.
  15. Rodrigues IFG, Machion L, Casati MZ, et al. Clinical Evaluation of the Use of Locally Delivered Chlorhexidine in Periodontal Maintenance Therapy. J Periodontol 2007;78:624–628. DOI: 10.1902/jop.2007. 060317.
  16. Attin R, Ilse A, Werner C, et al. Antimicrobial effectiveness of a highly concentrated chlorhexidine varnish treatment in teenagers with fixed orthodontic appliances. Angle Orthod 2006;76:1022–1027. DOI: 10.2319/070605-218.
  17. Imfeld T. Chlorhexidine containing chewing gum. Clinical documentation. Schweiz Monnatsschr Zahnmed 2006;116:476–483.
  18. Zanatta FB, Antoniazzi RD, Rosig CK. Staining and calculus formation after 0.12% chlorhexidine rinses in plaque-free and plaque covered surfaces: a randomized trial. J Appl Oral Sci 2010;18:515–521. DOI: 10.1590/S1678-77572010000500015.
  19. Soskolne WA, Chajek T, Flashner M, et al. An in vivo study of the chlorhexidine release profile of the PerioChip™ in the gingival crevicular fluid, plasma and urine. J Clin Periodontol 1998;25: 1017–1021. DOI: 10.1111/j.1600-051X.1998.tb02407.x.
  20. Marjorie JK, Bray KS, Sebestian G, et al. Adjunctive use of a subgingival release chlorhexidine chip reducing probing depth and improves attachment level compared with scaling and root planing alone. J Periodontol 1998;69:989–997. DOI: 10.1902/jop.1998.69.9.989.
  21. Goodson JM, Offenbacher S, Farr DH, et al. Periodontol disease treated by local drug delivery. J Periodontol 1985;56:265–272. DOI: 10.1902/jop.1985.56.5.265.
  22. Soskolne A, Gololmb G, Micheal F, et al. New sustained dosage form of chlorhexidine for dental use. L Periodontol Res 1983;18:330–336. DOI: 10.1111/j.1600-0765.1983.tb00368.x.
  23. Stabholz A, Sela M, Friedman M, et al. Clinical and microbiological effect of sustained release chlorhexidine in periodontal pocket. J Clin Periodontol 1986;13:787–788. DOI: 10.1111/j.1600-051X.1986.tb00882.x.
  24. Marjorie JK, Kent PG, Thomas WW, et al. Use of a biodegradable chlorhexidine chip in the treatment of adult periodontitis: clinical and radiographic findings. J Periodontol 2000;71:256–261. DOI: 10.1902/jop.2000.71.2.256.
  25. Grover V, Kapoor A, Malhotra R, et al. To assess the effectiveness of a chlorhexidine chip in the treatment of chronic periodontitis: a clinical and radiographic study. J Indian sos Periodontal 2011;15:139–146. DOI: 10.4103/0972-124X.84383.
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