Citation Information :
Nassani MZ, Al-Maweri SA, Veeraganta SK, Al-Shamiri HM, Alaizari NA, Najeeb S. Survival Rates of Dental Implants in Patients with Papillon–Lefévre Syndrome: A Systematic Review. J Contemp Dent Pract 2021; 22 (1):93-100.
Aim: The present review aimed to summarize and evaluate the available literature regarding the survival rate and outcomes of dental implants in patients with Papillon-Lefèvre syndrome (PLS). Materials and methods: An extensive search of the literature was conducted on PubMed, Scopus and Web of Science databases for all data published from January 1996 till April 2020 using a combination of the following keywords: ‘Papillon Lefévre Syndrome’, ‘prosthodontic rehabilitation’ and ‘dental implant’ according to the PRISMA guidelines for the focused research question constructed using the PICO criteria. Clinical trials and observational studies on implant placement in PLS patients reported in English language were included in the study. Results: A total of 10 studies (nine case reports and one case series) comprising 124 dental implants placed in 13 PLS patients were included. The follow-up period ranged from 4 months to 9 years. With regard to implant loading, 9 studies reported delayed loading, while one study did not provide any information regarding the nature of implant loading. The design of prosthodontic superstructure was either a removable or fixed prosthesis. Out of the 124 inserted implants, 20 (16%) were reported as failed. The overall survival rate was 84%. Conclusion: The limited available evidence suggests that the survival rate of dental implants in patients with PLS is lower than that among healthy individuals. Nevertheless, no strict contraindication for implant-supported prosthesis seems to be justified in this group of patients. Further longitudinal studies with adequate follow-up periods are highly warranted. Clinical significance: The prognosis of implant treatment for PLS patients has not yet been established. Dental practitioners should follow a careful approach in planning the dental implant treatment for this cohort of patients.
Papillon MM, Lefèvre P. Two cases of family symmetrical keratoderma palmar and plantar (disease of Meleda) in the brother and the sister. Coexistence in both cases of serious dental deteriorations. Bull Soc Fr Dermatol Syphiligr 1924;31:82–87.
Hart TC, Hart PS, Bowden DW, et al. Mutations of the cathepsin C gene are responsible for Papillon–Lefèvre syndrome. J Med Genet 1999;36(12):881–887. PMID: 10593994; PMCID: PMC1734286.
Machado RA, Cuadra-Zelaya FJM, Martelli-Júnior H, et al. Clinical and molecular analysis in Papillon–Lefèvre syndrome. Am J Med Genet A 2019;179(10):2124–2131. DOI: 10.1002/ajmg.a.61285.
Inalöz HS, Harman M, Akdeniz S, et al. Atypical familial Papillon–Lefèvre syndrome. J Eur Acad Dermatol Venereol 2001;15(1):48–50. DOI: 10.1046/j.1468-3083.2001.00121.x.
Gorlin RJ, Sedano H, Anderson VE. The syndrome of palmar-plantar hyperkeratosis and premature periodontal destruction of the teeth. A clinical and genetic analysis of the Papillon-Lefèvre syndrome. J Pediatr 1964;65(6):895–908. DOI: 10.1016/s0022-3476(64)80014-7.
Cury VF, Costa JE, Gomez RS, et al. A novel mutation of the cathepsin C gene in Papillon–Lefèvre syndrome. J Periodontol 2002;73(3): 307–312. DOI: 10.1902/jop.2002.73.3.307.
Galanter DR, Bradford S. Case report. Hyperkeratosis palmoplantaris and periodontosis: the Papillon–Lefèvre syndrome. J Periodontol 1969;40(1):40–47. DOI: 10.1902/jop.19220.127.116.11.
Hattab FN, Rawashdeh MA, Yassin OM, et al. Papillon–Lefèvre syndrome: a review of the literature and report of 4 cases. J Periodontol 1995;66(5):413–420. DOI: 10.1902/jop.1918.104.22.1683.
Siragusa M, Romano C, Batticane N, et al. A new family with Papillon–Lefèvre syndrome: effectiveness of etretinate treatment. Cutis 2000;65(3):151–155. PMID: 10738634.
Abou Chedid JC, Salameh M, El-Outa A, et al. Papillon–Lefèvre syndrome: diagnosis, dental management, and a case report. Case Rep Dent 2019:4210347. DOI: 10.1155/2019/4210347.
Wiebe CB, Häkkinen L, Putnins EE, et al. Successful periodontal maintenance of a case with Papillon-Lefèvre syndrome: 12-year follow-up and review of the literature. J Periodontol 2001;72(6): 824–830. DOI: 10.1902/jop.2001.72.6.824.
Tinanoff N, Tanzer JM, Kornman KS, et al. Treatment of the periodontal component of Papillon–Lefèvre syndrome. J Clin Periodontol 1986;13(1):6–10. DOI: 10.1111/j.1600-051x.1986.tb01407.x.
Ishikawa I, Umeda M, Laosrisin N. Clinical, bacteriological, and immunological examinations and the treatment process of two Papillon–Lefèvre syndrome patients. J Periodontol 1994;65(4): 364–371. DOI: 10.1902/jop.1922.214.171.1244.
Bergman R, Friedman-Birnbaum R. Papillon–Lefèvre syndrome: a study of the long-term clinical course of recurrent pyogenic infections and the effects of etretinate treatment. Br J Dermatol 1988;119(6):731–736. DOI: 10.1111/j.1365-2133.1988.tb03495.x.
Bullon P, Pascual A, Fernandez-Novoa MC, et al. Late onset Papillon–Lefévre syndrome? A chromosomic, neutrophil function and microbiological study. J Clin Periodontol 1993;20(9):662–667. DOI: 10.1111/j.1600-051x.1993.tb00712.x.
Pimentel SP, Kolbe MF, Pereira RS, et al. Papillon–Lefèvre syndrome in 2 siblings: case report after 11-year follow-up. Pediatr Dent 2012;34(7):231–236. PMID: 23265160.
Lundgren T, Renvert S. Periodontal treatment of patients with Papillon–Lefèvre syndrome: a 3-year follow-up. J Clin Periodontol 2004;31:933–938. DOI: 10.1111/j.1600-051X.2004.00591.x.
Rateitschak-Plüss EM, Schroeder HE. History of periodontitis in a child with Papillon–Lefèvre syndrome. A case report. J Periodontol 1984;55(1):35–46. DOI: 10.1902/jop.19126.96.36.199.
Van Dyke TE, Taubman MA, Ebersole JL, et al. The Papillon–Lefèvre syndrome: neutrophil dysfunction with severe periodontal disease. Clin Immunol Immunopathol 1984;31(3):419–429. DOI: 10.1016/0090-1229(84)90094-1.
Shapira J, Eidelman E, Fuks A, et al. Treatment of Papillon–Lefèvre syndrome with chemotherapy: report of cases. Spec Care Dentist 1985;5(2):71–74. DOI: 10.1111/j.1754-4505.1985.tb00389.x.
Ahmed B. Prosthodontic rehabilitation of Papillon Lefèvre syndrome. J Coll Physicians Surg Pak 2014;24(Suppl 2):132–134. PMID: 24906267.
Sharma A, Kaur G, Sharma A. Papillon–Lefèvre syndrome: a case report of 2 affected siblings. J Indian Soc Periodontol 2013;17(3):373–377. DOI: 10.4103/0972-124X.115643.
Etöz OA, Ulu M, Kesim B. Treatment of patient with Papillon–Lefèvre syndrome with short dental implants: a case report. Implant Dent 2010;19(5):394–399. DOI: 10.1097/ID.0b013e3181ed0798.
Al Farraj AlDosari A. Oral rehabilitation of a case of Papillon–Lefèvre syndrome with dental implants. Saudi Med J 2013;34(4):424–427. PMID: 23552598.
Fiske J, Davis DM, Frances C, et al. The emotional effects of tooth loss in edentulous people. Br Dent J 1998;184(2):90–93. DOI: 10.1038/sj.bdj.4809551.
Senel FC, Altintas NY, Bagis B, et al. A 3-year follow-up of the rehabilitation of Papillon–Lefèvre syndrome by dental implants. J Oral Maxillofac Surg 2012;70(1):163–167. DOI: 10.1016/j.joms.2011.03.058.
Lindstrom RE, Pawelchak J, Heyd A, et al. Physical-chemical aspects of denture retention and stability: a review of the literature. J Prosthet Dent 1979;42(4):371–375. DOI: 10.1016/0022-3913(79)90134-3.
Dhanrajani PJ. Papillon–Lefèvre syndrome: clinical presentation and a brief review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;108(1):1–7.
Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 2009;151(4):264–269. DOI: 10.7326/0003-4819-151-4-200908180-00135.
Schulz KF, Altman DG, Moher D, et al.. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. BMC Med 2010;8:Article No. 18. DOI: 10.1186/1741-7015-8-18.
Woo I, Brunner DP, Yamashita DD, et al. Dental implants in a young patient with Papillon–Lefèvre syndrome: a case report. Implant Dent 2003;12(1):140–144. PMID: 15591986.
Toygar HU, Kircelli C, Firat E, et al. Combined therapy in a patient with Papillon-Lefèvre syndrome: a 13-year follow-up. J Periodontol 2007;78(9):1819–1824. DOI: 10.1902/jop.2007.070004.
Rai R, Kumar A, Deshpande V. Papillone-Lefèvre syndrome—the prosthodontics management. J Pierre Fauchard Acad 2014;28(1):23–27. DOI: 10.1016/j.jpfa.2014.03.002.
Ullbro C, Crossner CG, Lundgren T, et al. Osseointegrated implants in a patient with Papillon–Lefèvre syndrome. A 4 1/2-year follow up. J Clin Periodontol 2000;27(12):951–954. DOI: 10.1034/j.1600-051x.2000.027012951.x.
Ahmadian L, Monzavi A, Arbabi R, et al. Full-mouth rehabilitation of an edentulous patient with Papillon–Lefèvre syndrome using dental implants: a clinical report. J Prosthodont 2011;20(8):643–648.doi: 10.1111/j.1532-849X.2011.00768.x.
Kinaia BM, Hope K, Zuhaili A, et al. Full-mouth rehabilitation with Calvarium bone grafts and dental implants for a Papillon–Lefèvre syndrome patient: case report. Int J Oral Maxillofac Implants 2017;32(6):259–264. DOI: 10.11607/jomi.6282.
Nickles K, Schacher B, Ratka-Krüger P, et al. Long-term results after treatment of periodontitis in patients with Papillon–Lefèvre syndrome: success and failure. J Clin Periodontol 2013;40(8):789–798. DOI: 10.1111/jcpe.12120.
Awad MA, Lund JP, Dufresne E, et al. Comparing the efficacy of mandibular implant-retained overdentures and conventional dentures among middle-aged edentulous patients: satisfaction and functional assessment. Int J Prosthodont 2003;16(2):117–122. PMID: 12737240.
Sakka S, Baroudi K, Nassani MZ. Factors associated with early and late failure of dental implants. J Investig Clin Dent 2012;3(4):258–261. DOI: 10.1111/j.2041-1626.2012.00162.x.
Al-Sabbagh M, Bhavsar I. Key local and surgical factors related to implant failure. Dent Clin North Am 2015;59(1):1–23. DOI: 10.1016/j.cden.2014.09.001.
Papaspyridakos P, Bordin TB, Natto ZS, et al. Complications and survival rates of 55 metal-ceramic implant-supported fixed complete-arch prostheses: a cohort study with mean 5-year follow-up. J Prosthet Dent 2019;122(5):441–449. DOI: 10.1016/j.prosdent.2019.01.022.
Papaspyridakos P, Mokti M, Chen CJ, et al. Implant and prosthodontic survival rates with implant fixed complete dental prostheses in the edentulous mandible after at least 5 years: a systematic review. Clin Implant Dent Relat Res 2014;16(5):705–717. DOI: 10.1111/cid.12036.
Karoussis IK, Brägger U, Salvi GE, et al. Effect of implant design on survival and success rates of titanium oral implants: a 10-year prospective cohort study of the ITI dental implant system Clin Oral Implants Res 2004;15(1):8–17. DOI: 10.1111/j.1600-0501.2004.00983.x.
Kern JS, Kern T, Wolfart S, et al. A systematic review and meta-analysis of removable and fixed implant-supported prostheses in edentulous jaws: post-loading implant loss. Clin Oral Implants Res 2016;27(2):174–195. DOI: 10.1111/clr.12531.
Bohner L, Hanisch M, Kleinheinz J, et al. Dental implants in growing patients: a systematic review. Br J Oral Maxillofac Surg 2019;57(5):397–406. DOI: 10.1016/j.bjoms.2019.04.011.
Op Heij DG, Opdebeeck H, van Steenberghe D, et al. Age as compromising factor for implant insertion. Periodontol 2000 2003;33:172–184. DOI: 10.1046/j.0906-6713.2003.03314.x.