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VOLUME 20 , ISSUE 6 ( June, 2019 ) > List of Articles


The Antifungal Effects of Two Herbal Essences in Comparison with Nystatin on the Candida Strains Isolated from the Edentulous Patients

Zeinab Khorram, Seyed MR Hakimaneh, Alireza Naeini, Reihane Rafieinezhad, Ali M Salari, Sayed S Shayegh

Keywords : Antifungal effect, Candida, Cumin, Fennel, Nystatin

Citation Information : Khorram Z, Hakimaneh SM, Naeini A, Rafieinezhad R, Salari AM, Shayegh SS. The Antifungal Effects of Two Herbal Essences in Comparison with Nystatin on the Candida Strains Isolated from the Edentulous Patients. J Contemp Dent Pract 2019; 20 (6):716-719.

DOI: 10.5005/jp-journals-10024-2585

License: CC BY-NC 4.0

Published Online: 01-07-2019

Copyright Statement:  Copyright © 2019; The Author(s).


Aim: The aim of this study is to evaluate the anticandidal effects of essential oils derived from fennel (Foeniculum vulgare) and cumin (Cuminum cyminum) on Candida strains isolated from edentulous patients. Materials and methods: Candida samples were isolated from 30 edentulous patients and the strains were identified using the CHROMagar method. Using the macro-broth dilution method and punched-hole tests, the effectiveness of fennel and cumin essential oils (prepared through distillation by water) was clarified. Nystatin was used as a positive control. Results: Nystatin (44 ìg/mL) had the strongest antifungal effect, followed by cumin [minimum inhibitory concentration (MIC) = 662 ìg/mL; minimum fungicidal concentration (MFC) = 630 ìg/mL] and fennel (MIC = 1,074 ìg/mL; MFC = 1,227 ìg/mL). The average diameter of the fungal growth inhibition zone was 23 mm for Nystatin, 14 mm for cumin essential oil, and 5 mm for fennel essential oil. Conclusion: The anti-Candida effects of fennel and cumin show promise as alternatives to conventional drugs for the treatment of Candida infections.

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