Citation Information :
Ramirez-Yanez GO, Scott JE. Architecture of the Mandibular Condylar Cartilage of Elderly Individuals: A Semiquantitative Light Microscopic Histological Study. J Contemp Dent Pract 2019; 20 (7):768-772.
Aim: This study aimed to categorize the constituent tissues of the mandibular condylar cartilage of elderly individuals.
Materials and methods: Thirty-three mandibular condyles were collected from 20 human cadavers of individuals between 40 years and 103 years old. Samples were stained with Masson's trichrome and Herovici's stains and, examined under a light microscope.
Results: All samples showed tissues that were categorized as fibrous and hyaline cartilage in the mandibular condylar cartilage. A thick fibrous cartilage layer was differentiated on the top of a thinner hyaline cartilage in all of the examined samples. Undifferentiated cells, as well as mature and hypertrophic chondroblasts, were observed in the layer identified as hyaline cartilage, even though they were not in an organized manner.
Conclusion: The observations from this study confirm that both fibrocartilage and hyaline cartilage are still present in the mandibular condylar cartilage of elderly individuals.
Clinical significance: The results from this study infer that the mandibular condylar cartilage could be still able to respond to stimulus in adults. In that context, the results of the present study set the basis for future studies aiming to elucidate the biological activity and the remodeling potential of the tissues at the mandibular condyle in adults.
Petrovic A. Auxologic categorization and chronobiologic specification for the choice of appropriate orthodontic treatment. Am J Orthod Dentofacial Orthop 1994;105(2):192–205. DOI: 10.1016/S0889-5406(94)70114-8.
Petrovic AG. Mechanisms and regulation of mandibular condylar growth. Acta Morphol Neerl Scand 1972;10(1):25–34.
Copray J, Dibbets J, et al. The role of condylar cartilage in the development of the temporomandibular joint. Angle Orthod 1988;58(4):369–380. DOI: 10.1043/0003-3219(1988)058<0369:TROCCI>2.0.CO;2.
Hansson T, Oberg T, et al. Thickness of the soft tissue layers and the articular disk in the temporomandibular joint. Acta Odontol Scand 1977;35(2):77–83. DOI: 10.3109/00016357709055993.
Nanci A. Ten Cate's Histology: Development, structure and function. St. Louis, Missouri: Mosby, 2008.
Petrovic AG, Stutzmann JJ, et al. The final length of the mandible: is it genetically predetermined? Craniofacial Biology. Univ. Michigan, 1981; pp. 105–126; Vol Monograph 10.
Liu Y, Behrents R, et al. Mandibular growth, remodeling, and maturation during infancy and early childhood. Angle Orthod 2010;80:97–105. DOI: 10.2319/020309-67.1.
Moffett B. The morphogenesis of the temporomadibular joint. Am J Orthod 1966;52:401–415. DOI: 10.1016/0002-9416(66)90120-5.
Wright D, Moffett BC. The postnatal development of the human temporomandibular joint. Am J Anat 1974;141:235–250. DOI: 10.1002/aja.1001410206.
Luder HU. Frequency and distribution of articular tissue features in adult human mandibular condyles: a semiquantitative light microscopic study. Anat Rec 1997;248(1):18–28. DOI: 10.1002/(SICI)1097-0185(199705)248:1<18::AID-AR3>3.0.CO;2-B.
Luder H. Age changes in the articular tissue of human mandibular condyles from adolescence to old age: a semiquantitative light microscopic study. Anat Rec 1998;251(4):439–447. DOI: 10.1002/(SICI)1097-0185(199808)251:4<439::AID-AR3>3.0.CO;2-N.
Pecora N, Baccetti T, et al. The aging craniofacial complex: a longitudinal cephalometric study from late adolescence to late adulthood. Am J Orthod Dentofacial Orthop 2008;134:496–505. DOI: 10.1016/j.ajodo.2006.11.022.
Thilander B, Carlsson G, et al. Postnatal development of the human temporomandibular joint. I. A histological study. Acta Odontol Scand 1976;34(2):117–126. DOI: 10.3109/00016357609026564.
Herovici C. A polychrome stain for differentiating precollagen from collagen. Stain Technol 1963;38:204–205.
Ramirez-Yanez G, Daley T, et al. Incisor disocclusion in rats affects mandibular condylar cartilage at the cellular level. Arch Oral Biol 2004;49(5):393–400. DOI: 10.1016/j.archoralbio.2003.11.005.
Ramirez-Yañez G, Young W, et al. Influence of growth hormone on the mandibular condylar cartilage of rats. Arch Oral Biol 2004;49(7):585–590. DOI: 10.1016/j.archoralbio.2004.02.004.
Flygare L, Klinge B, et al. Calcified cartilage zone and its dimensional relationship to the articular cartilage in the human temporomandibular joint of elderly individuals. Acta Odontol Scand 1993;51:183–191. DOI: 10.3109/00016359309041164.
Ishibashi H, Takenoshita Y, et al. Age-related changes in the human mandibular condyle: a morphologic, radiologic, and histologic study. J Oral Maxillofac Surg 1995;53:1016–1023. DOI: 10.1016/0278-2391(95)90117-5.
Oberg T, Carlsson G. Macroscopic and microscopic anatomy of the temporomandibular joint. In: Zarb G, Carlsson G ed., Temporomandibular joint function and dysfunction. Copenhagen: Munksgaard; 1979. pp. 101–118.
Petrovic A, Stutzmann J, et al. Control processes in postnatal growth of condylar cartilage of the mandible. In: McNamara JAJ ed., Determinants of mandibular form and growth. Monograph, 4th ed. Ann Arbor: University of Michigan; 1975. pp. 14–57.
Katakami K, Shimoda S, et al. Histological investigation of osseous changes of mandibular condyles with backscattered electron images. Dentomaxillofac Radiol 2008;37:330–339. DOI: 10.1259/dmfr/93169617.
Hattori K, Takakura Y, et al. Which cartilage is regenerated, hyaline cartilage or fibrocartilage? Non-invasive ultrasonic evaluation of tissue-engineered cartilage. Rheumatology 2004;43:1106–1108. DOI: 10.1093/rheumatology/keh256.