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VOLUME 20 , ISSUE 12 ( December, 2019 ) > List of Articles


Effect of Vitamin D on Canine Distalization and Alveolar Bone Density Using Multi-slice Spiral CT: A Randomized Controlled Trial

Sanju T Varughese, Pavithra U Shamanna, Neeraj Goyal, Beenu S Thomas, Lakshmi Lakshmanan, Venith J Pulikkottil, Mohammed G Ahmed

Keywords : Bone density, Canine distalization, Randomized controlled trial, Vitamin D

Citation Information : Varughese ST, Shamanna PU, Goyal N, Thomas BS, Lakshmanan L, Pulikkottil VJ, Ahmed MG. Effect of Vitamin D on Canine Distalization and Alveolar Bone Density Using Multi-slice Spiral CT: A Randomized Controlled Trial. J Contemp Dent Pract 2019; 20 (12):1430-1435.

DOI: 10.5005/jp-journals-10024-2698

License: CC BY-NC 4.0

Published Online: 01-04-2016

Copyright Statement:  Copyright © 2019; The Author(s).


Aim: The aim of this split-mouth, blinded randomized controlled trial was to evaluate the clinical and radiographic effects of locally delivered 1,25 dihydroxycholecalciferol (1,25 DHC) on the amount of canine distalization. Materials and methods: Fifteen patients between age groups of 15 years to 30 years willing to undergo orthodontic treatment in a dental college participated in the study. A computer-generated randomization list was generated to divide the maxillary arch into experimental side and control side. Allocation concealment was applied. Canine distalization was initiated using nickel–titanium (NiTi) closed coil springs delivering a force of 150 g per side, which was attached to the maxillary first molar tube and canine hook. Local periodontal gel injection of 1,25 DHC was given on the experimental side and placebo gel on the control side at distal side of the maxillary canine at monthly interval, respectively. Patients were evaluated from beginning (T0), 4 weeks (T1), 8 weeks (T2), and 12 weeks (T3). CT scans were taken at T0 and T3 to measure the changes in bone density. The difference in amount of canine distalization and the changes in bone density were assessed on the experimental and control sides, respectively. Descriptive statistics and paired t test were used to determine any differences. Results: The results showed statistically significant increase in the amount of canine distalization and decrease in cancellous bone density on the experimental side when compared to control side. Conclusion: The active form of vitamin D can be an effective agent to accelerate orthodontic tooth movement (OTM). Clinical significance: This study provides a new insight into the scope of vitamin D in clinical orthodontics and its innovative method of application to accelerate tooth movement in patients will revolutionize treatment as well as open newer boundaries in orthodontic research at a biomolecular level.

  1. Gameiro GH, Pereira-Neto JS, Magnani MB, et al. The influence of drugs and systemic factors on orthodontic tooth movement. J Clin Orthod 2007;41(2):73–78.
  2. Krishnan V, Davidovitch Z. Cellular, molecular, and tissue level reactions to orthodontic force. Am J Orthod Dentofacial Orthop 2006;129(4):469.e1–469.e32. DOI: 10.1016/j.ajodo.2005.10.007.
  3. Masella RS, Meister M. Current concepts in the biology of orthodontic tooth movement. Am J Orthod Dentofacial Orthop 2006;129(4): 458–468. DOI: 10.1016/j.ajodo.2005.12.013.
  4. Kale S, Kocadereli I, Atilla P, et al. Comparison of the effects of 1,25 dihydroxycholecalciferol and prostaglandin E2 on orthodontic tooth movement. Am J Orthod Dentofacial Orthop 2004;125(5):607–614. DOI: 10.1016/j.ajodo.2003.06.002.
  5. Yamasaki K, Shibata Y, Imai S, et al. Clinical application of prostaglandin E1 (PGE1) upon orthodontic tooth movement. Am J Orthod 1984;85(6):508–518. DOI: 10.1016/0002-9416(84)90091-5.
  6. Stark M, Sinclair PM. Effect of pulsed electromagnetic fields on orthodontic tooth movement. Am J Orthod Dentofacial Orthop 1987;91(2):91–104. DOI: 10.1016/0889-5406(87)90465-3.
  7. Saito M, Saito S, Ngan PW, et al. Interleukin 1 beta and prostaglandin E are involved in the response of periodontal cells to mechanical stress in vivo and in vitro. Am J Orthod Dentofacial Orthop 1991;99(3): 226–240. DOI: 10.1016/0889-5406(91)70005-H.
  8. Leiker BJ, Nanda RS, Currier GF, et al. The effects of exogenous prostaglandins on orthodontic tooth movement in rats. Am J Orthod Dentofacial Orthop 1995;108(4):380–388. DOI: 10.1016/s0889-5406(95)70035-8.
  9. Collins MK, Sinclair PM. The local use of vitamin D to increase the rate of orthodontic tooth movement. Am J Orthod Dentofacial Orthop 1988;94(4):278–284. DOI: 10.1016/0889-5406(88)90052-2.
  10. Katsumata A, Hirukawa A, Okumura S, et al. Relationship between density variability and imaging volume size in cone-beam computerized tomographic scanning of the maxillofacial region: an in vitro study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;107(3):420–425. DOI: 10.1016/j.tripleo.2008.05.049.
  11. Hoggan BR, Sadowsky C. The use of palatal rugae for the assessment of antero posterior tooth movements. Am J Orthod Dentofacial Orthop 2001;119(5):482–488. DOI: 10.1067/mod.2001.113001.
  12. Park HS, Lee YJ, Jeong SH, et al. Density of the alveolar and basal bones of the maxilla and the mandible. Am J Orthod Dentofacial Orthop 2008;133(1):30–37. DOI: 10.1016/j.ajodo.2006.01.044.
  13. Furstman L, Bernick S, Aldrich DA. Differential response incident to tooth movement. Am J Orthod 1971;59(6):600–608. DOI: 10.1016/0002-9416(71)90007-8.
  14. Diravidamani K, Sivalingam SK, Agarwal V. Drugs influencing orthodontic tooth movement: an overall review. J Pharm Bioallied Sci 2012;4(Suppl 2):S299–S303. DOI: 10.4103/0975-7406.100278.
  15. Bartzela T, Türp JC, Motschall E, et al. Medication effects on the rate of orthodontic tooth movement: a systematic literature review. Am J Orthod Dentofacial Orthop 2009;135(1):16–26. DOI: 10.1016/j.ajodo.2008.08.016.
  16. Malamed SF. The periodontal ligament (PDL) injection: an alternative to inferior alveolar nerve block. Oral Surg Oral Med Oral Pathol 1982;53(2):117–121. DOI: 10.1016/0030-4220(82)90273-0.
  17. Sharma V, McNeill JH. To scale or not to scale: the principles of dose extrapolation. Br J Pharmacol 2009;157(6):907–921. DOI: 10.1111/j.1476-5381.2009.00267.x.
  18. Boester CH, Johnston LE. A clinical investigation of the concepts of differential and optimal force in canine retraction. Angle Orthod 1974;44(2):113–119. DOI: 10.1043/0003-3219(1974)044<0113:ACIOTC>2.0.CO;2.
  19. Shin HO, Falck CV, Galanski M. Low-contrast detectability in volume rendering: a phantom study on multidetector-row spiral CT data. Eur Radiol 2004;14(2):341–349. DOI: 10.1007/s00330-003-2084-4.
  20. Lerner UH. Osteoblasts, osteoclasts, and osteocytes: unveiling their intimate-associated responses to applied orthodontic forces. Semin Orthod 2012;18:237–248.
  21. Hsu JT, Chang HW, Huang HL, et al. Bone-density changes around teeth during orthodontic treatment. Clin Oral Investig 2011;15(4): 511–519. DOI: 10.1007/s00784-010-0410-1.
  22. Mandall NA, Lowe C, Worthington HV, et al. Which orthodontic arch-wire sequence? A randomized clinical trial. Eur J Orthod 2006;28(6):561–566. DOI: 10.1093/ejo/cjl030.
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