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VOLUME 21 , ISSUE 2 ( February, 2020 ) > List of Articles


A Comparison of Dentin Tubule Occlusion Properties of Dipotassium Oxalate against Potassium Nitrate: An In Vitro Study

Viet Tran, Thanhphuong N Dinh, Thomas YH Yoon

Keywords : Dentin desensitizing agent, Dentin hypersensitivity, Dipotassium oxalate, Potassium nitrate

Citation Information : Tran V, Dinh TN, Yoon TY. A Comparison of Dentin Tubule Occlusion Properties of Dipotassium Oxalate against Potassium Nitrate: An In Vitro Study. J Contemp Dent Pract 2020; 21 (2):119-123.

DOI: 10.5005/jp-journals-10024-2754

License: CC BY-NC 4.0

Published Online: 01-02-2020

Copyright Statement:  Copyright © 2020; Jaypee Brothers Medical Publishers (P) Ltd.


Aim: The aim of this study is to compare the efficacy of dipotassium oxalate and potassium nitrate to occlude dentinal tubules. Materials and methods: This study utilized Parkinson model of longitudinal dentin tubule occluding properties of dentifrices under a 4-day acid challenge. Dentin disks of approximately 1.5 mm thick were sectioned from the crowns of the freshly extracted molars. The disks were randomized into three sets of 15 and treated with dipotassium oxalate, potassium nitrate, or used as a control. The disks were then subjected to a 4-day acid challenge and evaluated by scanning electron microscopy (SEM). Results: On days 1, 2, and 3, dipotassium oxalate showed significant occlusion of dentinal tubules. On day 4, no significant difference was observed between dipotassium oxalate and potassium nitrate. Both test groups showed better occlusion properties in comparison to the control. Conclusion: Through the use of a 4-day acid challenge, this study demonstrates that both agents can indeed occlude dentinal tubules. Initially, dipotassium oxalate does occlude dentinal tubules faster than potassium nitrate. However, at the conclusion of the acid challenge, minimal differences were observed in occlusion rate among the two agents. Further studies should be conducted to determine the efficacy of these two agents. Clinical significance: Both dipotassium oxalate and potassium nitrate can help treat patients with dentinal hypersensitivity.

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  1. Saeki K, Marshall GW, Gansky SA, et al. Strontium effects on root dentin tubule occlusion and nanomechanical properties. Dent Mater 2016;32(2):240–251. DOI: 10.1016/
  2. Schiff T, Delgado E, Zhang Y, et al. Clinical evaluation of the efficacy of an in-office desensitizing paste containing 8% arginine and calcium carbonate in providing instant and lasting relief of dentin hypersensitivity. Am J Dent 2009;22(Spec No. A):8A–15A.
  3. Brännström M, Lindén L, Aström A. The hydrodynamics of the dental tubule and of pulp fluid. Caries Res 1967;1(4):310–317. DOI: 10.1159/000259530.
  4. Jacobsen PL, Bruce G. Clinical dentin hypersensitivity: understanding the causes and prescribing a treatment. J Contemp Dent Pract 2001;2(1):1–12. DOI: 10.5005/jcdp-2-1-27.
  5. Nagata T, Ishida H, Shinohara H, et al. Clinical evaluation of a potassium nitrate dentifrice for the treatment of dentinal hypersensitivity. J Clin Periodontol 1994;21(3):217–221. DOI: 10.1111/j.1600-051X.1994.tb00307.x.
  6. Poulsen S, Errboe M, Hovgaard O, et al. Potassium nitrate toothpaste for dentine hypersensitivity. Cochrane Database Syst Rev 2001;2:CD001476. DOI: 10.1002/14651858.CD001476.
  7. Parkinson CR, Willson RJ. A comparative in vitro study investigating the occlusion and mineralization properties of commercial toothpastes in a four day dentin disc model. J Clin Dent 2011;22(3):74–81.
  8. Burnett G, Willson R, Lucas R. In vitro studies investigating the dentin tubule-occlusion properties of an experimental anhydrous stannous fluoride dentifrice. Am J Dent 2013;26(Spec No A):10A–14A.
  9. Parkinson CR, Hughes N, Jeffrey P, et al. The efficacy of a dentifrice containing 0.454% w/w stannous fluoride in providing relief from the pain of dentine hypersensitivity: an 8 week clinical study. Am J Dent 2013;26(Spec No A):25A–31A.
  10. Schiff T, Zhang YP, DeVizio W, et al. A randomized clinical trial of the desensitizing efficacy of three dentifrices. Compend Contin Educ Dent Suppl 2000;27:4–10.
  11. Arnold WH, Prange M, Naumova EA. Effectiveness of various toothpastes on dentine tubule occlusion. J Dent 2015;43(4):440–449. DOI: 10.1016/j.jdent.2015.01.014.
  12. Pashley DH, O'Meara JA, Kepler EE, et al. Dentin permeability. Effects of desensitizing dentifrices in vitro. J Periodontol 1984;55(9):522–525. DOI: 10.1902/jop.1984.55.9.522.
  13. Greenhill JD, Pashley DH. The effects of desensitizing agents on the hydraulic conductance of human dentin in vitro. J Dent Res 1981;60(3):686–698. DOI: 10.1177/00220345810600030401.
  14. Lynch MC, Perfekt R, McGuire JA, et al. Potassium oxalate mouthrinse reduces dentinal hypersensitivity: a randomized controlled clinical study. J Am Dent Assoc 2018;149(7):608–618. DOI: 10.1016/j.adaj.2018.02.027.
  15. Pereira JC, Segala AD, Gillam DG. Effect of desensitizing agents on the hydraulic conductance of human dentin subjected to different surface pre-treatments--an in vitro study. Dent Mater 2005;21(2):129–138. DOI: 10.1016/
  16. Eliades G, Mantzourani M, Labella R, et al. Interactions of dentine desensitisers with human dentine: morphology and composition. J Dent 2013;41(Suppl 4):S28–S39. DOI: 10.1016/S0300-5712(13)70004-6.
  17. Clark DC, Hanley JA, Geoghegan S, et al. Effectiveness of a fluoride varnish and a desensitizing toothpaste in treating dentinal hypersensitivity. J Periodontol Res 1985;20(2):212–219. DOI: 10.1111/j.1600-0765.1985.tb00428.x.
  18. Tarbet WJ, Buckner A, Stark MM, et al. The pulpal effects of brushing with a 5 percent potassium nitrate paste used for desensitization. Oral Surg Oral Med Oral Pathol 1981;51(6):600–602. DOI: 10.1016/S0030-4220(81)80009-6.
  19. Orchardson R, Gillam DG. The efficacy of potassium salts as agents for treating dentin hypersensitivity. J Orofac Pain 2000;14(1):9–19.
  20. Addy M, Mostafa P, Newcombe R. Dentine hypersensitivity: a comparison of five toothpastes used during a 6-week treatment period. Br Dent J 1987;163(2):45–51. DOI: 10.1038/sj.bdj. 4806185.
  21. Pinto SC, Silveira CM, Pochapski MT, et al. Effect of desensitizing toothpastes on dentin. Braz Oral Res 2012;26(5):410–417. DOI: 10.1590/S1806-83242012000500006.
  22. James JM, Puranik MP, Sowmya KR. Dentinal tubule occluding effect of potassium nitrate in varied forms, frequencies and duration: an in vitro SEM analysis. J Clin Diagn Res 2017;11(8):ZC06–ZC08. DOI: 10.7860/JCDR/2017/26442.10340.
  23. Mjör IA, Nordahl I. The density and branching of dentinal tubules in human teeth. Arch Oral Biol 1996;41(5):401–412. DOI: 10.1016/0003-9969(96)00008-8.
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