Citation Information :
Barry MJ, Almotawah F, Pani SC, Ingle NA. A Comparison of Salivary Mercury Levels in Children with Attention Deficit/Hyperactivity Disorder When Compared to Age-matched Controls: A Case-control Observational Study. J Contemp Dent Pract 2020; 21 (2):129-132.
Aim: The aim of this study was to compare the level of mercury in the saliva of children with attention deficit/hyperactivity disorder (ADHD) as compared to age- and gender-matched controls in specific age groups. Materials and methods: A case-control observational study design was used. In school children with ADHD and outpatient dental clinics of a university dental hospital, the participants were schoolchildren diagnosed with ADHD studying in the first grade (6–7 years), sixth grade (12–13 years), and ninth grade (15–16 years) and were gender-matched to children without ADHD attending regular classes in school. Ninety children with ADHD comprised the test group while 90 children without ADHD comprised the control group. Results: In this study, we found that children with ADHD had higher levels of salivary mercury than their age- and gender-matched counterparts; however, this difference was significant only in the 6–7 years of age group. The regression model showed a mild positive association between salivary mercury and ADHD; however, the association was not statistically significant. Conclusion: While there is some indication that salivary mercury may be higher in children with ADHD, there is insufficient evidence to establish a definite association between the two. Clinical significance: The study highlights the need to evaluate existing evidence on the role of mercury, especially salivary mercury, in ADHD.
Fulton BD, Scheffler RM, Hinshaw SP, et al. National variation of ADHD diagnostic prevalence and medication use: health care providers and education policies. Psychiatr Serv 2009;60(8):1075–1083. DOI: 10.1176/ps.2009.60.8.1075.
Simon V, Czobor P, Balint S, et al. Prevalence and correlates of adult attention-deficit hyperactivity disorder: meta-analysis. Br J Psychiatry 2009;194(3):204–211. DOI: 10.1192/bjp.bp.107.048827.
Alqahtani MM. Attention-deficit hyperactive disorder in school-aged children in Saudi Arabia. Eur J Pediatr 2010;169(9):1113–1117. DOI: 10.1007/s00431-010-1190-y.
Homidi M, Obaidat Y, Hamaidi D. Prevalence of attention deficit and hyperactivity disorder among primary school students in Jeddah city, KSA. Life Sci J 2013;10:280–285.
Alhraiwil NJ, Ali A, Househ MS, et al. Systematic review of the epidemiology of attention deficit hyperactivity disorder in Arab countries. Neurosciences 2015;20(2):137–144. DOI: 10.17712/nsj.2015.2.20140678.
Bose-O'Reilly S, McCarty KM, Steckling N, et al. Mercury exposure and children's health. Curr Probl Pediatr Adolesc Health Care 2010;40(8):186–215. DOI: 10.1016/j.cppeds.2010.07.002.
Azevedo BF, Barros Furieri L, Pecanha FM, et al. Toxic effects of mercury on the cardiovascular and central nervous systems. J Biomed Biotechnol 2012;2012:949048. DOI: 10.1155/2012/949048.
Kim S, Arora M, Fernandez C, et al. Lead, mercury, and cadmium exposure and attention deficit hyperactivity disorder in children. Environ Res 2013;126:105–110. DOI: 10.1016/j.envres.2013. 08.008.
Karouna-Renier NK, Rao KR, Lanza JJ, et al. Mercury levels and fish consumption practices in women of child-bearing age in the Florida Panhandle. Environ Res 2008;108(3):320–326. DOI: 10.1016/j.envres.2008.08.005.
Geier DA, Hooker BS, Kern JK, et al. A dose-response relationship between organic mercury exposure from thimerosal-containing vaccines and neurodevelopmental disorders. Int J Environ Res Public Health 2014;11(9):9156–9170. DOI: 10.3390/ijerph110909156.
Van Wijngaarden E, Thurston SW, Myers GJ, et al. Methyl mercury exposure and neurodevelopmental outcomes in the Seychelles child development study main cohort at age 22 and 24years. Neurotoxicol Teratol 2017;59:35–42. DOI: 10.1016/j.ntt.2016.10.011.
Geier DA, Kern JK, Homme KG, et al. The risk of neurodevelopmental disorders following Thimerosal-containing Hib vaccine in comparison to Thimerosal-free Hib vaccine administered from 1995 to 1999 in the United States. Int J Hyg Environ Health 2018;221(4):677–683. DOI: 10.1016/j.ijheh.2018.03.004.
Lygre GB, Aase H, Haug K, et al. Prenatal exposure to dental amalgam and risk of symptoms of attention-deficit and hyperactivity disorder (ADHD). Community Dent Oral Epidemiol 2018;46(5):472–481. DOI: 10.1111/cdoe.12409.
Patel NB, Xu Y, McCandless LC, et al. Very low-level prenatal mercury exposure and behaviors in children: the HOME Study. Environ Health. 2019;18(1):4. DOI: 10.1186/s12940-018-0443-5.
Zheng P, Li M, Jurevic R, et al. A gold nanohole array based surface-enhanced Raman scattering biosensor for detection of silver(I) and mercury(II) in human saliva. Nanoscale 2015;7(25):11005–11012.
Wordofa DN, Ramnani P, Tran TT, et al. An oligonucleotide-functionalized carbon nanotube chemiresistor for sensitive detection of mercury in saliva. Analyst 2016;141(9):2756–2760. DOI: 10.1039/c6an00018e.
Kawde AN. Trace determination of Hg(II) in human saliva using disposable electrochemically pretreated graphite pencil electrode surfaces. Acta Chim Slov 2017;64(2):267–275. DOI: 10.17344/acsi.2016.2538.
Yilmaz S, Adisen MZ. Ex vivo mercury release from dental amalgam after 7.0-T and 1.5-T MRI. Radiology. 2018;288(3):799–803. DOI: 10.1148/radiol.2018172597.
Lin PY, Wang J, Chiang YC, et al. Risk of subsequent attention-deficit/hyperactivity disorder among children and adolescents with amalgam restorations: a nationwide longitudinal study. Community Dent Oral Epidemiol 2018;46(1):47–53. DOI: 10.1111/cdoe.12327.
World Health Organization. Oral health surveys: basic methods. Geneva, Switzerland: World Health Organization; 2013.
Chien YC, Feldman CA, Zohn HK, et al. Urinary mercury levels before and after amalgam restoration. Sci Total Environ 1996;188(1):39–47. DOI: 10.1016/0048-9697(96)05155-8.
Drexler H, Schaller KH. The mercury concentration in breast milk resulting from amalgam fillings and dietary habits. Environ Res. 1998;77(2):124–129. DOI: 10.1006/enrs.1997.3813.