Assessment of the Role of Vitamin D in the Treatment of Oral Lichen Planus
Jazib Nazeer, Supriya Singh, Rohit Singh, Md A Iqubal
Keywords :
Autoimmune disorder, Oral lichen planus, Vitamin D
Citation Information :
Nazeer J, Singh S, Singh R, Iqubal MA. Assessment of the Role of Vitamin D in the Treatment of Oral Lichen Planus. J Contemp Dent Pract 2020; 21 (4):390-395.
Aim: Lichen planus is an autoimmune disease that can affect the skin and mucous membranes, including the oral mucosa. Vitamin D plays a very important role in the bone health along with boosting immunity. This study was carried out to assess the role of vitamin D in the treatment of oral lichen planus. Materials and methods: A sample size of 450 was taken which included patients showing clinical presentation of oral lichen planus. The patients were equally divided into three different groups based on their vitamin D levels. The data were analyzed using SPSS version 26.0. Results: The patients who were given the vitamin D supplementation showed the maximum improvement. The comparison of the data were found to be statistically significant. Conclusion: It was concluded that vitamin D played an important role in the treatment of oral lichen planus. Clinical significance: The role of vitamin D in lichen planus needs to be explored. This study may be useful in conducting further study to assess the role in vitamin D supplementation in the treatment of oral lichen planus.
Karthikeyan P, Kumaresan R, Yelamanachi B, et al. Oral lichen planus - a review. Indian J Public Health Res Dev 2019;10(6):224–227. DOI: 10.5958/0976-5506.2019.01271.3.
Gupta J, Aggarwal A, Asadullah MD, et al. Vitamin D in the treatment of oral lichen planus: a pilot clinical study. J Indian Acad Oral Med Radiol 2019;31(3):222–227. DOI: 10.4103/jiaomr.jiaomr_97_19.
Wang J, van der Waal I. Disease scoring systems for oral lichen planus; a critical appraisal. Med Oral Patol Oral Cir Bucal 2015;20(2):199–204. DOI: 10.4317/medoral.20524.
Bouillon R, Carmeliet G, Verlinden L, et al. Vitamin D and human health. Lessons from vitamin D receptor null mice. Endocr Rev 2008;29(6):726–776. DOI: 10.1210/er.2008-0004.
Bhalla AK, Amento EP, Clemens TL, et al. Specific high affinity receptors for 1,25-dihydroxyvitamin D3 in human peripheral blood mononuclear cells: presence in monocytes and induction in T lymphocytes following activation. J Clin Endocrinol Metab 1983;57(6):1308–1310. DOI: 10.1210/jcem-57-6-1308.
Veldman CM, Cantorna MT, DeLuca HF. Expression of 1,25-dihydroxyvitamin D (3) receptor in the immune system. Arch Biochem Biophys 2000;374(2):334–338. DOI: 10.1006/abbi.1999.1605.
Alroy I, Towers TL, Freedman LP. Transcriptional repression of the interleukin-2 gene by vitamin D3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor. Mol Cell Biol 1995;15(10):5789–5799. DOI: 10.1128/MCB.15.10.5789.
Cippitelli M, Santoni A. Vitamin D3: a transcriptional modulator of the interferon-gamma gene. Eur J Immunol 1998;28:3017–3030. DOI: 10.1002/(SICI)1521-4141(199810)28:10<3017::AIDIMMU3017> 3.0.CO;2-6.
Yu S, Cantorna MT. The vitamin D receptor is required or iNKT cell development. Proc Natl Acad Sci 2008;105:5207–5212. DOI: 10.1073/pnas.0711558105.
Iijima W, Ohtani H, Nakayama T, et al. Infiltrating CD8 T cells in oral lichen planus predominantly express CCR5 and CXCR3 and carry respective chemokine ligands RANTES/CCL% and IP-10/CXCL10 in their cytolytic granules. Am J Pathol 2003;163(1):261–268. DOI: 10.1016/S0002-9440(10)63649-8.
Cantrona MT, Snyder L, Lin Y-D, et al. Vitamin D and 1,25(OH)2D regulation of T cells. Nutrients 2015;7(4):3011–3021. DOI: 10.3390/nu7043011.
Gupta A, Prakash Sasankoti Mohan R, Kamarthi N, et al. Serum vitamin D level in oral lichen planus patients of north india - a case control study. JDRT 2017;1(2):19–35. DOI: 10.14302/issn.2471-2175.jdrt-17-1481.
Zhao B, Li R, Yang F, et al. LPS-induced vitamin D receptor decrease in oral keratinocytes is associated with oral lichen planus. Sci Rep 2018;8:1–9. DOI: 10.1038/s41598-018-19234-z.
Godschalk M, Levy JR, Downs RW. Glucocorticoids decrease vitamin D receptor number and gene expression in human osteosarcoma cells. J Bone Miner Res 1992;7(1):21–27. DOI: 10.1002/jbmr.5650070105.
Merlino LA, Curtis J, Mikuls TR, et al. Vitamin D intake is inversely associated with rheumatoid arthritis: results from the IOWA women’s health study. Arthritis Rheum 2004;50(1):72–77. DOI: 10.1002/art.11434.
Munger KL, Levin LI, Hollis BW, et al. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA 2006;296(23):2832–2838. DOI: 10.1001/jama.296.23.2832.
Linker-Israeli M, Elstner E, Klineberg JR, et al. Vitamin D (3) and its synthetic analogs inhibit the spontaneous in vitro immunoglobulin production by SLE-derived PBMC. Clin Immunol 2001;99(1):82–93. DOI: 10.1006/clim.2000.4998.
Beena Varma R, Valappila NJ, Pai A, et al. Oral lichen planus: Is vitamin D deficiency a predisposing factor? A case report. Int J Sci Stud 2014;2(7):230–232.
Du J, Li R, Yu F, et al. Experimental study on 1,25(OH)2D amelioration of oral lichen planus through regulating NF-kB signaling pathway. Oral Dis 2017;23(6):770–778. DOI: 10.1111/odi.12659.
