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VOLUME 21 , ISSUE 4 ( April, 2020 ) > List of Articles

ORIGINAL RESEARCH

Antibacterial Effect of Metronidazole vs Chlorhexidine Solutions in Treatment of Root Canals of Primary Anterior Teeth

Ibrahim Barakat, Mohamed A Elpatal, AlWaleed Abushanan, Bahaa Eldin Anwar Abd elrady

Keywords : Chlorhexidine, Dental caries, E. faecalis, Metronidazole, Pulpectomy

Citation Information : Barakat I, Elpatal MA, Abushanan A, Abd elrady BE. Antibacterial Effect of Metronidazole vs Chlorhexidine Solutions in Treatment of Root Canals of Primary Anterior Teeth. J Contemp Dent Pract 2020; 21 (4):396-399.

DOI: 10.5005/jp-journals-10024-2719

License: CC BY-NC 4.0

Published Online: 25-04-2012

Copyright Statement:  Copyright © 2020; The Author(s).


Abstract

The aim of this study was to evaluate and compare the antibacterial effect of 0.5% metronidazole, 2% chlorhexidine, and normal saline irrigant solutions against Enterococcus faecalis bacteria in the treatment of root canals of primary anterior teeth. Materials and methods: This study was carried out on sixty nonvital primary anterior teeth of Egyptian children diagnosed with ECC. These teeth were classified equally into three groups according to irrigation materials. A fresh sample was collected from each root canal after access opening before and 3 days after irrigation with the help of a paper point. The number of organisms (E. faecalis) before and after irrigation was compared for each group. Results: The bacterial count of E. faecalis was decreased in all groups however, these differences were statistically insignificant where (p <0.05). Conclusion: Both 0.5% metronidazole and 2.0% chlorhexidine appeared to be superior against E. faecalis bacteria as endodontic irrigants in pulpectomy anterior primary teeth with higher antibacterial efficacy compared to saline. Clinical significance: The success of endodontic treatment depends on the removal of microbes, from the root canals and avoidance of reinfection thus; this study provides an insight on the effects of different irrigant solutions to further help dental practitioners in the endodontic management of primary dentition.

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  1. Schilder H. Cleaning and shaping the root canal. Dent Clin North Am 1974;18:269–296.
  2. Gao Y, Fan B, Cheung GS, et al. C-shaped canal system in mandibular second molars part IV: 3-D morphological analysis and transverse measurement. J Endod 2006;32(11):1062–1065. DOI: 10.1016/j.joen.2006.05.014.
  3. Leonardo M, Tanomaru Filho M, Nelson Filho P, et al. In vivo antimicrobial activity of 2% chlorhexidine used as a root canal irrigating solution. J Endod 1999;25(3):167–171. DOI: 10.1016/S0099-2399(99)80135-6.
  4. Peters OA, Roehlike JO, Baumann MA. Effect of immersion in sodium hypochlorite on torque and fatigue resistance of nickeltitanium instruments. J Endod 2007;33(5):589–593. DOI: 10.1016/j.joen.2007.01.007.
  5. Hong S-T, Bae K-S, Baek S-H, et al. Effects of root canal irrigants on the push-out strength and hydration behavior of accelerated mineral trioxide aggregate in its early setting phase. J Endod 2010;36(12):1995–1999. DOI: 10.1016/j.joen.2010.08.039.
  6. Mitchell D. Metronidazole: Its use in clinical dentistry. J Clin Periodontol 1984;11(3):145–158. DOI: 10.1111/j.1600-051X.1984. tb01318.x.
  7. Marsh P, Martin M. Oral Microbiology 1999 4th ed., Oxford: Wright; 1999.
  8. Anargyros P, Astill D, Lim I. Comparison of improved BACTEC and Lowenstein-Jensen media for culture of mycobacteria fromclinical specimens. J Clin Microbiol 1990 Jun;28(6):1288–1291.
  9. Dentistry AAOP. Symposium on the prevention of oral disease in children and adolescents. Chicago, Ill; November 11-12, 2005: conference papers. Pediatr Dent 2006;28(2):96–198.
  10. DiAngelis AJ, Andreasen JO, Ebeleseder KA, et al. International association of dental traumatology guidelines for the management of traumatic dental injuries: 1. Fractures and luxations of permanent teeth. Dent Traumatol 2012;28(1):2–12. DOI: 10.1111/j.1600-9657.2011.01103.x.
  11. Zamany A, Safavi K, Spångberg LS. The effect of chlorhexidine as an endodontic disinfectant. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003;96(5):578–581. DOI: 10.1016/S1079-2104(03) 00168-9.
  12. Knöfler G, Purschwitz R, Jentsch H, et al. Gingival crevicular fluid levels of aspartate aminotransferase and alpha 2 macroglobulin before and after topical application of metronidazole or scaling and root planing. Quintessence Int 2008;39(5):381–389.
  13. Keller U, Hibst R. Wirkungsweise und indikationen des er: YAG lasers in der Zahn-Mund-und Kieferheilkunde. Magazin für ZMK 1992;4: 6–10.
  14. Önçağ Ö, Hoşgör M, Hilmioğlu S, et al. Comparison of antibacterial and toxic effects of various root canal irrigants. Int Endod J 2003;36(6):423–432. DOI: 10.1046/j.1365-2591.2003.00673.x.
  15. Gardner TB, Hill DR. Treatment of giardiasis. Clin Microbiol Rev 2001;14(1):114–128. DOI: 10.1128/CMR.14.1.114-128.2001.
  16. Gaetti-Jardim EC, Marqueti AC, Faverani LP, et al. Antimicrobial resistance of aerobes and facultative anaerobes isolated from the oral cavity. J Appl Oral Sci 2010;18(6):551–559. DOI: 10.1590/S1678-77572010000600004.
  17. Andrade C, Bustamante D, Cabrera OFG, et al. Comparación entre clorhexidina e hipoclorito de sodio como soluciones desinfectantes en la práctica endodóntica. Revista Kiru 2017;14(1).
  18. Mohammadi Z, Abbott PV. Antimicrobial substantivity of root canal irrigants and medicaments: A review. Aust Endod J 2009;35(3): 131–139. DOI: 10.1111/j.1747-4477.2009.00164.x.
  19. Sassone LM, Fidel RAS, Fidel SR, et al. Antimicrobial activity of different concentrations of NaOCl and chlorhexidine using a contact test. Braz Dent J 2003;14(2):99–102. DOI: 10.1590/S0103-64402003000200005.
  20. Menezes M, Valera M, Jorge A, et al. In vitro evaluation of the effectiveness of irrigants and intracanal medicaments on microorganisms within root canals. Int Endod J 2004;37(5):311–319. DOI: 10.1111/j.0143-2885.2004.00799.x.
  21. Siqueira JF, Paiva SS, Rôças IN. Reduction in the cultivable bacterial populations in infected root canals by a chlorhexidine-based antimicrobial protocol. J Endod 2007;33(5):541–547. DOI: 10.1016/j.joen.2007.01.008.
  22. Shen Y, Stojicic S, Haapasalo M. Antimicrobial efficacy of chlorhexidine against bacteria in biofilms at different stages of development. J Endod 2011;37(5):657–661. DOI: 10.1016/j.joen.2011.02.007.
  23. Hoshino E, Iwaku M, Sato M, et al. Bactericidal efficacy of metronidazole against bacteria of human carious dentin in vivo. Caries Res 1989;23(2):78–80. DOI: 10.1159/000261161.
  24. Sato T, Hoshino E, Uematsu H, et al. Bactericidal efficacy of a mixture of ciprofloxacin, metronidazole, minocycline and rifampicin against bacteria of carious and endodontic lesions of human deciduous teeth in vitro. Microb Ecol Health Dis 1992;5(4):171–177. DOI: 10.3109/08910609209141583.
  25. Gajan EB, Aghazadeh M, Abashov R, et al. Microbial flora of root canals of pulpally-infected teeth: enterococcus faecalis a Prevalent species. J Dent Res Dent Clin Dent Prospects 2009;3(1):24–27. DOI: 10.5681/joddd.2009.007.
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