The Journal of Contemporary Dental Practice

Register      Login

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue

Online First

Archive
Volume  25 (2024)
Volume  24 (2023)
Volume  23 (2022)
Volume  22 (2021)
Volume  21 (2020)
Volume  20 (2019)
Volume  19 (2018)
Volume  18 (2017)
Volume  17 (2016)
Volume  16 (2015)
Volume  15 (2014)
Volume  14 (2013)
Volume  13 (2012)
Volume  12 (2011)
Volume  11 (2010)
Volume  10 (2009)
Volume  9 (2008)
Volume  8 (2007)
Volume  7 (2006)
Volume  6 (2005)
Volume  5 (2004)
Volume  4 (2003)
Volume  3 (2002)
Volume  2 (2001)
Volume  1 (1999)
Related articles

VOLUME 21 , ISSUE 6 ( June, 2020 ) > List of Articles

ORIGINAL RESEARCH

Effectiveness of Toothpaste Containing REFIX Technology against Dentin Hypersensitivity: A Randomized Clinical Study

Fabiano V Vilhena, Mackeler R Polassi, Eloisa AC Paloco, Roberta CB Alonso, Ricardo D Guiraldo, Paulo HP D Alpino

Citation Information : Vilhena FV, Polassi MR, Paloco EA, Alonso RC, Guiraldo RD, D Alpino PH. Effectiveness of Toothpaste Containing REFIX Technology against Dentin Hypersensitivity: A Randomized Clinical Study. J Contemp Dent Pract 2020; 21 (6):609-614.

DOI: 10.5005/jp-journals-10024-2847

License: CC BY-NC 4.0

Published Online: 04-11-2020

Copyright Statement:  Copyright © 2020; The Author(s).


Abstract

Aim: This clinical study aimed to evaluate the efficacy of a toothpaste containing a proprietary REFIX technology (Regenerador + Sensitive DentalClean, Rabbit Corp) against dentin hypersensitivity. Materials and methods: Fifty-three volunteers who fulfilled the inclusion criteria and signed the consent form were included. They were examined for dentin hypersensitivity. The participants received a 1-second blast of air, and the tooth sensitivity, from 0 to 10, was immediately evaluated using a visual analog scale (VAS). Then, the participants brushed their teeth with the multifunctional toothpaste, and dentin hypersensitivity was tested a second time using the same scale. The participants continued to use the toothpaste three times a day for 1 week, after which dentin hypersensitivity was recorded for the third time. Data were statistically analyzed using analysis of variance (ANOVA) and Tukey's test (α = 0.05). Results: The mean patient age was 40 years, and 70% of the 53 subjects were female. There was a significant reduction in dentin hypersensitivity immediately after using the toothpaste and after 1 week. The baseline mean patient-reported pain score was severe (6.5 ± 2.4). Immediately after the first use of the toothpaste, the mean reported pain significantly decreased to mild pain (2.5 ± 2.5) (p < 0.05). After 1 week of consistent use of the toothpaste, the pain score reduced significantly (0.7 ± 1.2) (p < 0.05), and most participants reported no pain, demonstrating the effectiveness of the REFIX technology against dentin hypersensitivity. Conclusion: This clinical trial shows that the use of the phosphate-based desensitizing toothpaste containing REFIX technology significantly reduces dentin hypersensitivity after 1 week of consistent use. Clinical significance: The absence of pain, a desired clinical condition in patients with dentin hypersensitivity, was reached with the use of desensitizing toothpaste containing REFIX technology after 1 week of use. Such condition positively impacts quality of life, providing a healthier daily routine for patients.

HTML PDF Share
  1. Davari A, Ataei E, Assarzadeh H. Dentin hypersensitivity: Etiology, diagnosis and treatment; A literature review. J Dent (Shiraz) 2013;14(3):136–145.
  2. Hu ML, Zheng G, Zhang YD, et al. Effect of desensitizing toothpastes on dentine hypersensitivity: a systematic review and meta-analysis. J Dent 2018;75:12–21. DOI: 10.1016/j.jdent.2018.05.012.
  3. George AA, Muruppel AM, Sudeep S, et al. A comparative evaluation of the effectiveness of three different modalities in occluding dentinal tubules: an in vitro study. J Contemp Dent Pract 2019;20(4):454–459. DOI: 10.5005/jp-journals-10024-2538.
  4. Bekes K, John MT, Schaller HG, et al. Oral health-related quality of life in patients seeking care for dentin hypersensitivity. J Oral Rehabil 2009;36(1):45–51. DOI: 10.1111/j.1365-2842.2008.01901.x.
  5. Splieth CH, Tachou A. Epidemiology of dentin hypersensitivity. Clin Oral Investig 2013;17(Suppl 1):S3–S8. DOI: 10.1007/s00784-012-0889-8.
  6. Cunha-Cruz J, Wataha JC, Heaton LJ, et al. The prevalence of dentin hypersensitivity in general dental practices in the northwest United states. J Am Dent Assoc 2013;144(3):288–296. DOI: 10.14219/jada.archive.2013.0116.
  7. Miglani S, Aggarwal V, Ahuja B. Dentin hypersensitivity: Recent trends in management. J Conserv Dent 2010;13(4):218–224. DOI: 10.4103/0972-0707.73385.
  8. Rosing CK, Fiorini T, Liberman DN, et al. Dentine hypersensitivity: analysis of self-care products. Braz Oral Res 2009;23(Suppl 1):56–63. DOI: 0.1590/S1806-83242009000500009.
  9. Bartold PM. Dentinal hypersensitivity: a review. Aust Dent J 2006;51(3):212–218. DOI: 10.1111/j.1834-7819.2006.tb00431.x.
  10. Meurman JH, Vesterinen M. Wine, alcohol, and oral health, with special emphasis on dental erosion. Quintessence Int 2000;31(10):729–733.
  11. Petersson LG. The role of fluoride in the preventive management of dentin hypersensitivity and root caries. Clin Oral Investig 2013;17(Suppl 1):S63–S71. DOI: 10.1007/s00784-012-0916-9.
  12. Casals E, Boukpessi T, McQueen CM, et al. Anticaries potential of commercial dentifrices as determined by fluoridation and remineralization efficiency. J Contemp Dent Pract 2007;8(7):1–10. DOI: 10.5005/jcdp-8-7-1.
  13. Cury JA, Tenuta LM. Evidence-based recommendation on toothpaste use. Braz Oral Res 2014;28(spe):1–7. DOI: 10.1590/S1806-83242014.50000001.
  14. Cochran DL. Inflammation and bone loss in periodontal disease. J Periodontol 2008;79(Suppl 8):1569–1576. DOI: 10.1902/jop.2008.080233.
  15. Addy M, West NX. The role of toothpaste in the aetiology and treatment of dentine hypersensitivity. Monogr Oral Sci 2013;23:75–87. DOI: 10.1159/000350477.
  16. Kim S. Hypersensitive teeth: Desensitization of pulpal sensory nerves. J Endod 1986;12(10):482–485. DOI: 10.1016/S0099-2399(86)80203-5.
  17. Peacock JM, Orchardson R. Effects of potassium ions on action potential conduction in A- and C-fibers of rat spinal nerves. J Dent Res 1995;74(2):634–641. DOI: 10.1177/00220345950740020301.
  18. Peacock JM, Orchardson R. Action potential conduction block of nerves in vitro by potassium citrate, potassium tartrate and potassium oxalate. J Clin Periodontol 1999;26(1):33–37. DOI: 10.1034/j.1600-051x.1999.260106.x.
  19. Ganss C, Klimek J, Starck C. Quantitative analysis of the impact of the organic matrix on the fluoride effect on erosion progression in human dentine using longitudinal microradiography. Arch Oral Biol 2004;49(11):931–935. DOI: 10.1016/j.archoralbio.2004.05.010.
  20. Philip N. State of the art enamel remineralization systems: the next frontier in caries management. Caries Res 2019;53(3):284–295. DOI: 10.1159/000493031.
  21. Delbem ACB, Pessan JP. Alternatives to enhance the anticaries effects of fluoride. In: Coelho Leal S, Takeshita EM. Pediatric Restorative Dentistry. Cham: Springer International Publishing; 2019. pp. 75–92.
  22. West N, Seong J, Davies M. Dentine hypersensitivity. Monogr Oral Sci 2014;25:108–122. DOI: 10.1159/000360749.
  23. Joao-Souza SH, Scaramucci T, Buhler Borges A, et al. Influence of desensitizing and anti-erosive toothpastes on dentine permeability: an in vitro study. J Dent 2019. 103176. DOI: 10.1016/j.jdent.2019. 07.014.
  24. Bekes K, Heinzelmann K, Lettner S, et al. Efficacy of desensitizing products containing 8% arginine and calcium carbonate for hypersensitivity relief in MIH-affected molars: An 8-week clinical study. Clin Oral Investig 2017;21(7):2311–2317. DOI: 10.1007/s00784-016-2024-8.
  25. Ayad F, Ayad N, Vazquez J, et al. Use of a toothpaste containing 8% arginine and calcium carbonate for immediate and lasting relief of dentin hypersensitivity: a simple and effective in-office procedure. Am J Dent 2018;31(3):135–140.
  26. Schiff T, Delgado E, Zhang YP, et al. Clinical evaluation of the efficacy of an in-office desensitizing paste containing 8% arginine and calcium carbonate in providing instant and lasting relief of dentin hypersensitivity. Am J Dent 2009;22:8A–15A.
  27. Delgado DA, Lambert BS, Boutris N, et al. Validation of digital visual analog scale pain scoring with a traditional paper-based visual analog scale in adults. J Am Acad Orthop Surg Glob Res Rev 2018;2(3):e088. DOI: 10.5435/JAAOSGlobal-D-17-00088.
  28. Hammer Ø, Harper DAT, Ryan PD. PAST: paleontological statistics software package for education and data analysis. Palaeontol Electron 2001;4(1):9.
  29. Pirca K, Balbin-Sedano G, Romero-Tapia P, et al. Remineralizing effect of casein phosphopeptide-amorphous calcium phosphate and sodium fluoride on artificial tooth enamel erosion: an in vitro study. J Contemp Dent Pract 2019;20(11):1254–1259. DOI: 10.5005/jp-journals-10024-2710.
  30. Mello SV, Arvanitidou E, Stranick MA, et al. Mode of action studies of a new desensitizing mouthwash containing 0.8% arginine, PVM/MA copolymer, pyrophosphates, and 0.05% sodium fluoride. J Dent 2013;41(Suppl 1):S12–S19. DOI: 10.1016/j.jdent.2012.11.001.
  31. Moreno EC, Kresak M, Zahradnik RT. Fluoridated hydroxyapatite solubility and caries formation. Nature 1974;247(5435):64–65. DOI: 10.1038/247064a0.
  32. Silva HM, Mateescu M, Ponche A, et al. Surface transformation of silicon-doped hydroxyapatite immersed in culture medium under dynamic and static conditions. Colloids Surf B Biointerfaces 2010;75(1):349–355. DOI: 10.1016/j.colsurfb.2009.09.009.
  33. Parker AS, Patel AN, Al Botros R, et al. Measurement of the efficacy of calcium silicate for the protection and repair of dental enamel. J Dent 2014;42(Suppl 1):S21–S29. DOI: 10.1016/S0300-5712(14) 50004-8.
  34. Greenhill JD, Pashley DH. The effects of desensitizing agents on the hydraulic conductance of human dentin in vitro. J Dent Res 1981;60(3):686–698. DOI: 10.1177/00220345810600030401.
  35. Larsen MJ, Richards A. The influence of saliva on the formation of calcium fluoride-like material on human dental enamel. Caries Res 2001;35(1):57–60. DOI: 10.1159/000047432.
  36. Lussi A, Hellwig E. Risk assessment and causal preventive measures. Monogr Oral Sci 2014;25:220–229. DOI: 10.1159/000360612.
  37. Meyer F, Amaechi BT, Fabritius HO, et al. Overview of calcium phosphates used in biomimetic oral care. Open Dent J 2018;12(1): 406–423. DOI: 10.2174/1874210601812010406.
  38. Lagerlof F, Saxegaard E, Barkvoll P, et al. Effects of inorganic orthophosphate and pyrophosphate on dissolution of calcium fluoride in water. J Dent Res 1988;67(2):447–449. DOI: 10.1177/00220345880670020201.
  39. Mellberg JR, Petrou ID, Deutchman M, et al. The effects of 1% pyrophosphate and 0.02% sodium fluoride on artificial caries lesions in vivo. J Dent Res 1988;67(12):1461–1465. DOI: 10.1177/00220345880670120401.
  40. Ibsen CJS, Birkedal H. Pyrophosphate-inhibition of apatite formation studied by in situ X-ray diffraction. Minerals 2018;6(2):1–9. DOI: 10.3390/min8020065.
  41. Wang Z, Sa Y, Sauro S, et al. Effect of desensitising toothpastes on dentinal tubule occlusion: a dentine permeability measurement and SEM in vitro study. J Dent 2010;38(5):400–410. DOI: 10.1016/j.jdent.2010.01.007.
  42. Tomaz PLS, Sousa LA, Aguiar KF, et al. Effects of 1450-ppm fluoride-containing toothpastes associated with boosters on the enamel remineralization and surface roughness after cariogenic challenge. Eur J Dent 2020;14(1):161–170. DOI: 10.1055/s-0040-1705072.
  43. Jin J, Sklar GE, Min Sen OV, et al. Factors affecting therapeutic compliance: a review from the patient's perspective. Ther Clin Risk Manag 2008;4(1):269–286. DOI: 10.2147/tcrm.s1458.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.