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VOLUME 22 , ISSUE 5 ( May, 2021 ) > List of Articles


Why do Only Certain Cases of Oral Submucous Fibrosis Undergo Malignant Transformation?

Monal Yuwanati, Amol Gadbail, Shailesh Gondivkar, Gargi S Sarode

Citation Information : Yuwanati M, Gadbail A, Gondivkar S, Sarode GS. Why do Only Certain Cases of Oral Submucous Fibrosis Undergo Malignant Transformation?. J Contemp Dent Pract 2021; 22 (5):463-464.

DOI: 10.5005/jp-journals-10024-3101

License: CC BY-NC 4.0

Published Online: 09-07-2021

Copyright Statement:  Copyright © 2021; The Author(s).


  1. Li YC, Cheng AJ, Lee LY, et al. Multifaceted mechanisms of areca nuts in oral carcinogenesis: the molecular pathology from precancerous condition to malignant transformation. J Cancer 2019;10(17):4054–4062. DOI: 10.7150/jca.29765.
  2. Chang MCC, Ho YS, Lee PH, et al. Areca nut extract and arecoline induced the cell cycle arrest but not apoptosis of cultured oral KB epithelial cells: association of glutathione, reactive oxygen species and mitochondrial membrane potential. Carcinogenesis 2001;22(9):1527–1535. DOI: 10.1093/carcin/22.9.1527.
  3. Jeng JH, Chang MC, Hahn LJ. Role of areca nut in betel quid-associated chemical carcinogenesis: {Current} awareness and future perspectives. Oral Oncol 2001;37(6):477–492. DOI: 10.1016/S1368-8375(01)00003-3.
  4. Ahmad M, Ali S, Ali A, et al. Epidemiological and etiological study of oral submucous fibrosis among gutkha chewers of Patna, Bihar, India. J Indian Soc Pedod Prev Dent 2006;24(2):84–89. DOI: 10.4103/0970-4388.26022.
  5. Chandrarekha V, Kotrashetti V, Bhat K, et al. Effects of areca nut extracts on the neutrophil functions in blood and saliva samples of subjects with normal oral mucosa with and without areca nut habit: a comparative study. J Dr NTR Univ Heal Sci 2020;9(3):183. DOI: 10.4103/jdrntruhs.jdrntruhs_124_20.
  6. Harrandah AM, Chukkapalli SS, Bhattacharyya I, et al. Fusobacteria modulate oral carcinogenesis and promote cancer progression. J Oral Microbiol 2021;13(1). DOI: 10.1080/20002297.2020.1849493.
  7. Shukla K, Vun I, Lov I, et al. Role of Candida infection in the malignant transformation of oral leukoplakia: a systematic review of observational studies. Transl Res Oral Oncol 2019;4:2057178X1982822. DOI: 10.1177/2057178x19828229.
  8. Anila K, Hallikeri K, Shubhada C, et al. Comparative study of Candida in oral submucous fibrosis and healthy individuals. Rev Odonto Ciência 2011;26(1):71–76. DOI: 10.1590/S1980-65232011000100016.
  9. Gupta B, Chandra S, Raj V, et al. Comparison of salivary flow and candidal carriage in patients with oral submucous fibrosis. J Oral Maxillofac Pathol 2015;19(2):158–163. DOI: 10.4103/0973-029X.164526.
  10. Krogh P, Hald B, Holmstrup P. Possible mycological etiology of oral mucosal cancer: catalytic potential of infecting Candida aibicans and other yeasts in production of N-nitrosobenzylmethylamine. Carcinogenesis 1987;8(10):1543–1548. DOI: 10.1093/carcin/8.10.1543.
  11. O'Grady JF, Reade PC. Candida albicans as a promoter of oral mucosal neoplasia. Carcinogenesis 1992;13(5):783–786. DOI: 10.1093/carcin/13.5.783.
  12. Darling MR, McCord C, Jackson-Boeters L, et al. Markers of potential malignancy in chronic hyperplastic candidiasis. J Investig Clin Dent 2012;3(3):176–181. DOI: 10.1111/j.2041-1626.2012.00120.x.
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