The Journal of Contemporary Dental Practice

Register      Login



Volume / Issue

Online First

Related articles

VOLUME 22 , ISSUE 10 ( October, 2021 ) > List of Articles


Effect of Antibiotics and Carbohydrate Diet Control Instructions in Improving Glycated Hemoglobin among Type II Diabetic Patients with Periodontitis

Manea Musa Al-Ahmari

Keywords : Antibiotics, Diabetes, Glycated hemoglobin, Periodontitis

Citation Information : Al-Ahmari MM. Effect of Antibiotics and Carbohydrate Diet Control Instructions in Improving Glycated Hemoglobin among Type II Diabetic Patients with Periodontitis. J Contemp Dent Pract 2021; 22 (10):1118-1122.

DOI: 10.5005/jp-journals-10024-3185

License: CC BY-NC 4.0

Published Online: 07-02-2022

Copyright Statement:  Copyright © 2021; The Author(s).


Aim: This study was aimed to assess the effect of the scaling and root planing (SRP) with or without doxycycline and received carbohydrate diet control instructions in improving glycated hemoglobin (HbA1c) among type II diabetes mellitus (DM) patients diagnosed with periodontitis. Materials and methods: Nonrandomized clinical study design was conducted among 150 patients who were referred to the specialist dental centers in Abha city, between April 2019 and March 2021. The patients were allocated into two groups. Those receiving SRP with doxycycline were classified as group A, whereas patients who received SRP alone were classified as group B. The HbA1c levels were assessed at the baseline, and 3, 6, 12, and 24 months. Statistical package for the social sciences SPSS version 26 was used. p <0.05 was considered statistically significant. Results: There is a statistically significant difference in HbA1c level between the two groups during follow-up after 3, 6, 12, and 24 months (p <0.001, p <0.001, p <0.001, and p <0.001, respectively). Moreover, the improvement in HbA1c level was significantly observed after 24 months of follow-up in group A compared to group B (p <0.001) and most of this improvement was after the first 3 months of the follow-up. Conclusion: The SRP associated with doxycycline is more effective in improving HbA1c level among type II DM patients diagnosed with periodontitis than SRP alone. Most of the improvement is seen after 3 months of the follow-up. Clinical significance: Valuable information is provided for dental professionals about the importance of prescription of antibiotics with the periodontal treatment in improving the HbA1c level in type II DM patients.

  1. Raman RPC, Taiyeb-Ali TB, Chan SP, et al. Effect of nonsurgical periodontal therapy versus oral hygiene instructions on type 2 diabetes subjects with chronic periodontitis: a randomised clinical trial. BMC Oral Health 2014;14(1):1–10. DOI: 10.1186/1472-6831-14-79.
  2. Katagiri S, Nitta H, Nagasawa T, et al. Effect of glycemic control on periodontitis in type 2 diabetic patients with periodontal disease. J Diabetes Investig 2013;4(3):320–325. DOI: 10.1111/jdi.12026.
  3. Munjal A, Jain Y, Kote S, et al. A study on the change in HbA1c levels before and after non-surgical periodontal therapy in type-2 diabetes mellitus in generalized periodontitis. J Family Med Prim Care 2019;8(4):1326. DOI: 10.4103/jfmpc.jfmpc_105_19.
  4. O'Connell PA, Taba Jr M, Nomizo A, et al. Effects of periodontal therapy on glycemic control and inflammatory markers. J Periodontol 2008;79(5):774–783. DOI: 10.1902/jop.2008.070250.
  5. Teshome A, Yitayeh A. The effect of periodontal therapy on glycemic control and fasting plasma glucose level in type 2 diabetic patients: systematic review and meta-analysis. BMC Oral Health 2017;17(1):1–11. DOI: 10.1186/s12903-016-0249-1.
  6. Talakey AA, Hughes F, Almoharib H, et al. The added value of periodontal measurements for identification of diabetes among Saudi adults. J Periodontol 2021;92(1):62–71. DOI: 10.1002/JPER.20-0118.
  7. Aranzazu-Moya GC, Hernández-Castañeda AA, Archila Antolinez LH. Effects of periodontal therapy with topical antibiotics in the glycemic control of diabetic patients: systematic review. Rev Estomatol 2019;27(1):31–42. DOI: 10.25100/re.v27i1.8735.
  8. Katagiri S, Nitta H, Nagasawa T, et al. Multi-center intervention study on glycohemoglobin (HbA1c) and serum, high-sensitivity CRP (hsCRP) after local anti-infectious periodontal treatment in type 2 diabetic patients with periodontal disease. Diabetes Res Clin Pract 2009;83(3):308–315. DOI: 10.1016/j.diabres.2008.10.016.
  9. Tsobgny-Tsague NF, Lontchi-Yimagou E, Nana ARN, et al. Effects of nonsurgical periodontal treatment on glycated hemoglobin on type 2 diabetes patients (PARODIA 1 study): a randomized controlled trial in a sub-Saharan Africa population. BMC Oral Health 2018;18(1): 1–8. DOI: 10.1186/s12903-018-0479-5.
  10. Bharti P, Katagiri S, Nitta H, et al. Periodontal treatment with topical antibiotics improves glycemic control in association with elevated serum adiponectin in patients with type 2 diabetes mellitus. Obes Res Clin Pract 2013;7(2):e129–e138. DOI: 10.1016/j.orcp.2011.11.005.
  11. Das AC, Das SJ, Panda S, et al. Adjunctive effect of doxycycline with conventional periodontal therapy on glycemic level for chronic periodontitis with type 2 diabetes mellitus subjects. J Contemp Dent Pract 2019;20(12):1417–1423. DOI: 10.5005/jp-journals-10024-2722. PMID: 32381843.
  12. Macedo GO, Novaes AB, Souza SLS, et al. Additional effects of aPDT on nonsurgical periodontal treatment with doxycycline in type II diabetes: a randomized, controlled clinical trial. Lasers Med Sci 2014;29(3):881–886. DOI: 10.1007/s10103-013-1285-6.
  13. Al-Zahrani MS, Bamshmous SO, Alhassani AA, et al. Short-term effects of photodynamic therapy on periodontal status and glycemic control of patients with diabetes. J Periodontol 2009;80(10):1568–1573. DOI: 10.1902/jop.2009.090206.
  14. Singh S, Kumar V, Kumar S, et al. The effect of periodontal therapy on the improvement of glycaemic control in patients with type 2 diabetes mellitus: a randomized controlled clinical trial. Int J Diabetes Dev Ctries 2008;28(2):38–44. DOI: 10.4103/0973-3930.43097.
  15. Rodrigues DC, Taba MJ, Novaes AB, et al. Effect of non-surgical periodontal therapy on glycemic control in patients with type 2 diabetes mellitus. J Periodontol 2003;74(9):1361–1367. DOI: 10.1902/jop.2003.74.9.1361.
  16. Grossi SG, Skrepcinski FB, DeCaro T, et al. Treatment of periodontal disease in diabetics reduces glycated hemoglobin. J Periodontol 1997;68:713–719. DOI: 10.1902/jop.1997.68.8.713.
  17. Skaleric U, Schara R, Medvescek M, et al. Periodontal treatment by Arestin and its effects on glycemic control in type 1 diabetes patients. J Int Acad Periodontol 2004;6(4 Suppl.):160–165. PMID: 15536785. Available from:
  18. Simpson TC, Weldon JC, Worthington HV, et al. Treatment of periodontal disease for glycaemic control in people with diabetes mellitus. Cochrane Database Syst Rev 2015;(11):CD004714. DOI: 10.1002/14651858.CD004714.pub3.
  19. Qureshi A, Bokhari SAH, Haque Z, et al. Clinical efficacy of SRP with and without metronidazole on glycemic control: three-arm randomized controlled trial. BMC Oral Health 2021;21(1):253. DOI: 10.1186/s12903-021-01620-1.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.