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VOLUME 22 , ISSUE 10 ( October, 2021 ) > List of Articles


Assessment of the Effectiveness of Different Fluoride-releasing Bonding Agents on Prevention of Enamel Demineralization around Orthodontic Bracket: An In Vitro Study

Rashtra Bhushan, Shruti Shivakumar, T Faraz Afzal, Abdul Saheer, Thara Chandran

Keywords : Bonding agents, Enamel demineralization, Fluoride release, Premolar brackets

Citation Information : Bhushan R, Shivakumar S, Afzal TF, Saheer A, Chandran T. Assessment of the Effectiveness of Different Fluoride-releasing Bonding Agents on Prevention of Enamel Demineralization around Orthodontic Bracket: An In Vitro Study. J Contemp Dent Pract 2021; 22 (10):1130-1134.

DOI: 10.5005/jp-journals-10024-3161

License: CC BY-NC 4.0

Published Online: 07-02-2022

Copyright Statement:  Copyright © 2021; The Author(s).


Aim: The aim of the current research was to evaluate the efficacy of different fluoride-releasing bonding products in preventing enamel demineralization around orthodontic brackets by using a scanning electron microscope (SEM). Materials and methods: This research was performed using 80 healthy human premolar teeth that were extracted in course of orthodontic therapy. Until use, the sample premolars were subjected to storage in 0.1% thymol. Each premolar was thereafter cleansed with pumice for 10 seconds. Stainless steel brackets for premolars were employed. The 80 samples were allocated at random to one of the four groups (20 in each) as follows: Group I, control; group II, Transbond Plus color change adhesive; group III, GC Fuji Ortho LC; and group IV, Vitremer. An hour following bonding, all samples were subjected to pH cycling at a temperature of 37°C for a 14-day period. The premolar teeth were assessed below SEM. Analysis was performed with the one-way analysis of variance. Statistical significance was set at a p-value less than 0.05. Results: The extreme area of demineralization was abridged by the use of Transbond™ Plus color change adhesive (108.19 ± 0.68), trailed by GC Fuji Ortho LC (119.24 ± 0.37) use, Vitremer (121.56 ± 0.92) as well as the control group (141.88 ± 1.09) in that order. And there was a statistically significant difference found between the groups (p <0.001). Tukey's honestly significant difference (HSD) was employed in an overall comparison of mean areas of enamel demineralization, which depicted that differences were significant statistically with the exception of group III and group IV. Conclusion: The current research came to a conclusion that the Transbond Plus color change adhesive group was more potent in significant inhibition of demineralization areas in comparison to GC Fuji Ortho LC group and Vitremer group. Clinical significance: In course of fixed orthodontic therapy, demineralization of enamel is an inherent occurrence. Multiple approaches are being continually developed to avoid the formation of white spot lesions (WSLs) that compromise esthetics and cause deprived remineralization that enhances the menace of dental caries. Bonding agents that can release fluorides are thus considered highly efficacious.

  1. Demling A, Elter C, Heidenblut T, et al. Reduction of biofilm on orthodontic brackets with the use of a polytetrafluoroethylene coating. Eur J Orthod 2010;32(4):414–418. DOI: 10.1093/ejo/cjp142.
  2. Al Mulla AH, Al Kharsa S, Kjellberg H, et al. Caries risk profiles in orthodontic patients at follow-up using cariogram. Angle Orthod 2009;79(2):323–330. DOI: 10.2319/012708-47.1.
  3. da Silva SR, da Silva LAH, Basting RT, et al. Evaluation of the anticariogenic potential and bond strength to enamel of different fluoridated materials used for bracket bonding. Rev Odontol UNESP 2017;46(3):138–146. DOI: 10.1590/1807-2577.06716.
  4. Benson PE, Parkin N, Millett DT, et al. Fluorides for the prevention of white spots on teeth during fixed brace treatment. Cochrane Database Syst Rev 2004;3:CD003809. DOI: 10.1002/14651858.CD003809.pub2.
  5. Rix D, Foley T, Banting D, et al. A comparison of fluoride release by resin-modified GIC and polyacid modified composite resin. Am J Orthod Dentofacial Orthop 2001;120(4):398–405. DOI: 10.1067/mod.2001.116083.
  6. Chandru TP, Yahiya MB, Peedikayil FC, et al. Comparative evaluation of three different toothpastes on remineralization potential of initial enamel lesions: a scanning electron microscopic study. Indian J Dent Res 2020;31(2):217–223. DOI: 10.4103/ijdr.IJDR_745_18.
  7. White SN, Paine ML, Ngan AY, et al. Ectopic expression of dentin sialoprotein during amelogenesis hardens bulk enamel. J Biol Chem 2007;282(8):5340–5345. DOI: 10.1074/jbc.M604814200.
  8. Swapna G, Sharma S, Soni VP, et al. Demineralization adjacent to orthodontic brackets with fluoride releasing and conventional bonding agents. Indian J Dent Res 2016;27(4):426–432. DOI: 10.4103/0970-9290.191894.
  9. Barik AK, Duggal R. Comparative evaluation of fluoride release from chemically cured and light-cured orthodontic bonding agents and surface alteration of enamel: an in vitro study. J Indian Orthodont Soc 2020;54(3):233–239. DOI: 10.1177/0301574220937525.
  10. Ten Cate JM, Buijs MJ, Miller CC, et al. Elevated fluoride products enhance remineralization of advanced enamel lesions. J Dent Res 2008;87(10):943–947. DOI: 10.1177/154405910808701019.
  11. Hu W, Featherstone JD. Prevention of enamel demineralization: an in-vitro study using light-cured filled sealant. Am J Orthod Dentofacial Orthop 2005;128(5):592–600. DOI: 10.1016/j.ajodo. 2004.07.046.
  12. Cury JA, Tenuta LM. Enamel remineralization: controlling the caries disease or treating early caries lesions? Braz Oral Res 2009;23(Suppl. 1): 23–30. DOI: 10.1590/s1806-83242009000500005.
  13. Arnold WH, Haase A, Hacklaender J, et al. Effect of pH of amine fluoride containing toothpastes on enamel remineralization in vitro. BMC Oral Health 2007;7:14. DOI: 10.1186/1472-6831-7-14.
  14. Wilson RM, Donly KJ. Demineralization around orthodontic brackets bonded with resin-modified glass ionomer cement and fluoride-releasing resin composite. Pediatr Dent 2001;23(3):255–259. Available from:
  15. Passalini P, Fidalgo TK, Caldeira EM, et al. Preventive effect of fluoridated orthodontic resins subjected to high cariogenic challenges. Braz Dent J 2010;21(3):211–215. DOI: 10.1590/s0103-64402010000300006.
  16. Wandera A, Spencer P, Bohaty B. In vitro comparative fluoride release, and weight and volume change in light-curing and self-curing glass ionomer materials. Pediatr Dent 1996;18(3):210–214. Available from:
  17. Claydon NC. Current concepts in toothbrushing and interdental cleaning. Periodontol 2000 2008;48:10–22. DOI: 10.1111/j.1600-0757.2008.00273.x.
  18. Derks A, Kujipens-Jagtman AM, Frencken JE. Caries preventive measures used in orthodontic practices: an evidence-based decision? Am J Orthod Dentofacial Orthop 2007;132(2):165–170. DOI: 10.1016/j.ajodo.2005.10.028.
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