The Journal of Contemporary Dental Practice

Register      Login

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue

Online First

Archive
Related articles

VOLUME 12 , ISSUE 5 ( September-October, 2011 ) > List of Articles

RESEARCH ARTICLE

Successful Management of Bleeding after Dental Procedures with Application of Blood Stopper: A Single Center Prospective Trial

Yavuz Beyazit, Tayyar Kart, Ahmet Kuscu, Alper Arslan, Mevlut Kurt, Bora Aktas, Murat Kekilli, Ibrahim Haznedaroglu

Citation Information : Beyazit Y, Kart T, Kuscu A, Arslan A, Kurt M, Aktas B, Kekilli M, Haznedaroglu I. Successful Management of Bleeding after Dental Procedures with Application of Blood Stopper: A Single Center Prospective Trial. J Contemp Dent Pract 2011; 12 (5):379-384.

DOI: 10.5005/jp-journals-10024-1063

Published Online: 01-06-2012

Copyright Statement:  Copyright © 2011; The Author(s).


Abstract

Aim

Ankaferd Blood Stopper (ABS), as an herbal complementary medicine, has been approved for the management of clinical hemorrhages in Turkey, including dental interventions. Basic, preclinical and clinical studies disclosed the settings of the topical hemostatic use of ABS. The aim of this study is therefore to assess the efficacy and safety of ABS as an antihemorrhagic agent in the bleedings associated with dental procedures in patients with normal and impaired hemostasis.

Materials and methods

ABS has been topically applied by homogeneously spraying to the 113 patients during dental interventions within its on-label indications. A median of 0.5 ml (IQR:0.5-1 ml) ABS was administered after tooth extraction with prolonged hemorrhages.

Results

After the administration, bleeding stopped in less than 10 seconds in 59 (52.2%) patients, and below 22.5 seconds (IQR: 18, 8-30) in 54 patients (47.8%). A total of 141 procedures were performed in these 113 patients, and nearly 72.5 ml ABS was used with a total cost of 98 €.

Conclusion

ABS as a new herbal medicine was found to be an effective method for controlling bleeding related to dental procedures. No patient had wound infection and the healing process appeared to be normal. Topical ABS could be useful for the local hemostasis and wound healing in periodontal surgeries.

Clinical significance

In this prospective study ABS, for the first time, has demonstrated its potential for being an effective hemostatic agent for the management of bleedings due to dental procedures.

How to cite this article

Beyazit Y, Kart T, Kuscu A, Arslan A, Kurt M, Aktas B, Kekilli M, Haznedaroglu I. Successful Management of Bleeding after Dental Procedures with Application of Blood Stopper: A Single Center Prospective Trial. J Contemp Dent Pract 2011;12(5):379-384.


PDF Share
  1. Evaluation of hemostatic effects of Ankaferd as an alternative medicine. Altern Med Rev 2010;15:329-36.
  2. Haemostatic actions of the folkloric medicinal plant extract Ankaferd Blood Stopper. J Int Med Res 2008;36:163-70.
  3. Bleeding disorders: Characterization, dental considerations and management. J Can Dent Assoc 2006;72:827.
  4. Haemostatic efficacy of Ankaferd Blood Stopper in a swine bleeding model. Med Princ Pract 2009;18:165-69.
  5. In vivo haemostatic Effect of the medicinal plant extract Ankaferd Blood Stopper in rats pretreated with warfarin. Clin Appl Thromb Hemost 2009;15:270-76.
  6. The efficacy of Ankaferd Blood Stopper in antithrombotic drug induced primary and secondary hemostatic abnormalities of a rat bleeding model. Blood Coagul Fibrinolysis 2009;20:185-190.
  7. Endobronchial application of Ankaferd Blood Stopper to control profuse lung bleeding leading to hypoxemia and hemodynamic instability. Resp Med 2009;2:144-46.
  8. New anticoagulant agent for CABG surgery. Eur J Clin Invest 2008;38:341.
  9. Use of Ankaferd Blood Stopper for controlling actively bleeding fundal varices. Singapore Med J 2011;52:e11-2.
  10. Endoscopic application of Ankaferd Blood Stopper as a novel experimental treatment modality for upper gastrointestinal bleeding: A case report. Am J Gastroenterol 2008;103:2156-58.
  11. Ankaferd Blood Stopper as an effective adjunctive hemostatic agent for the management of life-threatening arterial bleeding of the digestive tract. Endoscopy 2008;40:E262.
  12. Tandem oral, rectal, and nasal administrations of Ankaferd Blood Stopper to control profuse bleeding leading to hemodynamic instability. Am J Emerg Med 2009;27:631.e1-2.
  13. Effectiveness of Ankaferd Blood Stopper in the topical control of active bleeding due to cutaneous-subcutaneous incisions. Saudi Med J 2009;30:1520-25.
  14. Topical Ankaferd Blood Stopper administration to bleeding gastrointestinal carcinomas decreases tumor vascularization. Am J Gastroenterol 2009;104:2874-77.
  15. Prospective, controlled clinical trial of Ankaferd Blood Stopper in children undergoing tonsillectomy. Int J Pediatr Otorhinolaryngol 2009;73:1742-45.
  16. Dental extraction for patients on oral anticoagulant therapy. Oral Surg Oral Med Oral Pathol 1990;70:274-77.
  17. Prevention of postoperative bleeding in anticoagulated patients undergoing oral surgery: Use of platelet-rich plasma gel. J Oral Maxillofac Surg 2003;61:1275-78.
  18. Management options for dental extraction in hemophiliacs: A study of 55 extractions (2000-2002). Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005;99:270-75.
  19. Hereditary blood coagulation disorders: Management and dental treatment. J Dent Res 2005;84:978-85.
  20. Comparison of 2 hemostatic agents for the prevention of postextraction hemorrhage in patients on anticoagulants. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001;92:257-59.
  21. Management of dental extractions in patients with bleeding disorders. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002;93:247-50.
  22. Evaluation of desmopressin for dental extractions in patients with hemostatic disorders. Oral Surg Oral Med Oral Pathol 1994;77:6-12.
  23. In vitro anti-bacterial activities of Ankaferd Blood Stopper. Int J Lab Hematol 2008;30:95.
  24. Antimicrobial activity of plant extract Ankaferd Blood Stopper. Fitoterapia 2009;80:48-50.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.