In vitro Antifungal Activity of Two Tissue Conditioners Combined with Nystatin, Miconazole and Fluconazole against Candida albicans
Amol Pharande, Narendra Chopde, Mayur N Khade, Yogesh R Khadtare, Sanket S Shah, Abhishek Apratim
Citation Information :
Pharande A, Chopde N, Khade MN, Khadtare YR, Shah SS, Apratim A. In vitro Antifungal Activity of Two Tissue Conditioners Combined with Nystatin, Miconazole and Fluconazole against Candida albicans. J Contemp Dent Pract 2012; 13 (5):695-698.
To determine and compare antifungal activity of two tissue conditioners combined with nystatin, miconazole and fluconazole against Candida albicans.
Materials and methods
Two tissue conditioners Viscogel and GC Soft combined with nystatin, miconazole and fluconazole were tested against Candida albicans using agar core inhibition diameter assay. One-way analysis of variance followed by Tukey's post-hoc test was used to test the intergroup difference. p-value < 0.05 was considered statistically significant.
Results
Maximum inhibition was seen in the fluconazole groups followed by miconazole and the least inhibition was seen in case of nystatin group.
Conclusion
Tissue conditioners when mixed with antifungal agents showed satisfactory inhibition of Candida albicans.
Clinical significance
Incorporation of antifungal drugs into tissue conditioners shows good inhibition of C. albicans and can be recommended for clinical use.
How to cite this article
Chopde N, Pharande A, Khade MN, Khadtare YR, Shah SS, Apratim A. In vitro Antifungal Activity of Two Tissue Conditioners Combined with Nystatin, Miconazole and Fluconazole against Candida albicans. J Contemp Dent Pract 2012;13(5):695-698.
The effectiveness, in vitro, of miconazole and keteconazole combined with tissue conditioners in inhibiting the growth of Candida albicans. J Oral Rehab 1985;12:177-82.
The relation of stimulated salivary flow rate and pH to Lactobacillus and yeast concentrations in saliva. J Dent Res 1981;60:1929-35.
The prevalence and intraoral distribution of Candida albicans in man. Arch Oral Biol 1980;25:1-10.
In vivo presence and growth of Candida albicans on resilient denture liners. J Prosthet Dent 1991;65:528-32.
The treatment of denture-induced stomatitis. Evaluation of two agents. Br Dent J 1981;151:416-19.
Household products as sanitising agents in denture cleansing. J Dent Assoc S Afr 1992;47:437-39
Effect of an antifungal denture liner on the saliva yeast count in patients with denture stomatitis: A pilot study. J Oral Rehabi 2008;35:664-69.
Efficacy of antifungal agents in tissue conditioners in treating candidiasis. Gerodontology 1999;16:110-18.
Adherence of Candida albicans to experimental denture soft lining materials. J Prosthet Dent 1997;77:306-12.
In vivo and in vitro study of fungal presence and growth on three tissue conditioning materials on implant supported complete denture wearers. J Oral Rehabil 1998;25:135-38.
Response of processed resilient denture liners to Candida albicans. J Prosthet Dent 1987;57:507-12.
Retention of Candida albicans on acrylic resin and silicone of different surface topography. J Prosthet Dent 1997;77:535-39.
The prevention of growth of Candida on silastic 390 soft liner for dentures. J Prosthet Dent 1975;33:250-57.
Antifungal activity of denture soft lining material modified by silver nanoparticles—A pilot study. Int J Mol Sci 2011;12:4735-44.
A review of oral infections and appropriate therapy. J Am Dent Assoc 1995;126:63-72.
The effectiveness of magnesium oxide combined with tissue conditioners in inhibiting the growth of Candida albicans: An in vitro study. Indian J Dent Res 2011;22:613.
Antifungal activity of nystatin, miconazole and fluconazole incorporated into four denture liners (in vitro study). J College Dent 2002;14:103-10.
Treatment of Candida infected denture stomatitis with amiconazole lacquer. Oral Surg Oral Med Oral Pathol 1994;78(3):306-11.
The in vitro fungicidal properties of Viscogel, alone and combined with nystatin and amphotericin B. J Oral Rehabil 1978;5:162-72.
Sensitivity to miconazole of microorganistns associated with angular cheilitis. Br Dent J 1978;144:199.
Nystatin in denture liners an alternative treatment of denture stomatitis. Brit Dent J 1973;135:55-59.
The efficacy of antifungal agents incorporated into heat cured acrylic denture base resin (Thesis). University of Baghdad, 2000.
