The Journal of Contemporary Dental Practice

Register      Login

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue

Online First

Archive
Related articles

VOLUME 13 , ISSUE 6 ( November-December, 2012 ) > List of Articles

RESEARCH ARTICLE

Effect of Methylxanthines (Coffee/tea Consumers) on Oral Precancer and Oral Cancer Patients with Smoking and Smokless Tobacco Habits

Bijle Mohammed Nadeem Ahmed, Yasmeen F Zubairy, Vinayak W Patil, Tabita Benjamin, Daya Jangam

Citation Information : Ahmed BM, Zubairy YF, Patil VW, Benjamin T, Jangam D. Effect of Methylxanthines (Coffee/tea Consumers) on Oral Precancer and Oral Cancer Patients with Smoking and Smokless Tobacco Habits. J Contemp Dent Pract 2012; 13 (6):745-748.

DOI: 10.5005/jp-journals-10024-1221

Published Online: 01-12-2012

Copyright Statement:  Copyright © 2012; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Aim

To study, whether the consumption of regular tea/coffee (methylxanthines) increases the risk of oral cancer in patients with smoking and smokeless tobacco habits.

Materials and methods

This study was conducted on a total of 90 oral cancer and precancerous patients, from western Maharashtra (India) males in the age group of 20 to 45 years who were with smoking and smokeless tobacco habits; also regular tea/coffee consumers were subjected to biochemical parameters such as aspartate transaminase (AST) and alanine transaminase (ALT) from saliva and serum of patients with oral precancer (submucous fibrosis, leukoplakia) and oral cancer patients and compared with 90-age and sex-matched controls. Individuals consent was taken to measure their biochemical parameters, by using Hafkenscheid method in whole saliva and serum. Statistical analysis of variance (ANOVA) with Tukey's correction for multiple group comparisons was performed using Student t-test.

Results

Results show, that a statistically significant increase in value (p < 0.05) in ALT, AST in both saliva and serum was observed in precancerous and oral cancer patients among the study group as compared to the control group.

Conclusion

In the present study, there was increase in the levels of ALT, AST enzymes in both saliva and serum levels in the study group as compared to the control group which was statistically significant (p < 0.05) suggesting that long-term exposure of methylxanthines results in impairment of salivary gland antioxidant system which may affect the anticarcinogenic action of saliva.

Clinical significance

Oral fluids may be utilized effectively to study the variations in the biochemical constituents of saliva of leukoplakia, submucous fibrosis and oral cancer patients.

How to cite this article

Zubairy YF, Patil VW, Benjamin T, Jangam D, Bijle MNA, Patil S. Effect of Methylxanthines (Coffee/ tea Consumers) on Oral Precancer and Oral Cancer Patients with Smoking and Smokless Tobacco Habits. J Contemp Dent Pract 2012;13(6):745-748.


PDF Share
  1. In vivo evidence that theophylline is metabolized principally by CYP1A in rats. Pharmacology 1993 Jul;47(1):1-7.
  2. Characterisation of theophylline metabolism by human liver microsomes. Inhibition and immunochemical studies. Biochem Pharmacol 1988 May 1;37(9):1651-59.
  3. Head and neck cancer a global perspective on epidemiology and prognosis. Anticancer Res 1998;18:4779-86.
  4. Oral cancer (4th ed). Hamilton; BC Becker 1998;25-40.
  5. Recommended methods for the determination of four enzymes in blood. Scand J Chin Lab Invest 1974;33:291-306.
  6. Oral fluid as a diagnostic tool. Clin Chem Lab Med 2004;42(11):1273-87.
  7. Experimental tongue cancer in desalivated rats. Oral Oncol 1997 Mar;33(2):105-09.
  8. Human saliva inactivates mutagenicity of carcinogens. Mutat Res 1981 Oct;85(5):323-33.
  9. Influence of pyridoxa-5-phosphate on the determination of alanine aminotransferas and aspartate aminotransferase of commercial test sera. J Clin Chem Clin Biochem 1979 Apr;17(4):219-23.
  10. Salivary biomarkers for clinical applications. Mol Diagn Ther 2009;13(4):245-59.
  11. Biotransformation of caffeine and theophylline in mammalian cell lines genetically engineered for expression of single cytochrome P450 isoforms. Biochem Pharmacol 1992 Jan 22;43(2):225-35.
  12. Effect of caffeine on the hepatic microsomal mixed function oxidase system during Phenobarbital and benzo [a] pyrene treatment in rats. Toxicol Lett 1988 Aug;42(2):109-15.
  13. Molecular markers of risk of oral cancer. N Engl J Med 2001 Apr 26;344(17):1323-26.
  14. Human cytochrome P450 enzymes. In Cytochrome P450. In: Ortiz de Montellano (Ed). Plenum Publishers, New York 1995:473-535.
  15. Tobacco associated lesions of oral cavity part 1: Nonmalignant lesions. J Can Dent Assoc 2000 May;66(5):252-56.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.