Aim: Aim of the current research was to assess the effect of different disinfectant solutions on the color steadiness of denture base materials. Materials and methods: Ninety samples were made employing the Meliodent and ProBase Hot heat cure denture base resin materials. Metallic disks measuring 3 mm thick as well as 20 mm in diameter were utilized to make the samples. Forty-five samples of every denture base material were immersed in three chemical disinfectants: 2% alkaline glutaraldehyde, 0.5% chlorhexidine gluconate, 0.5% sodium hypochlorite solution as well as distilled water that served as a control. Color scoring was performed at baseline and following first, 14th as well as 21 days. Color was calculated as per CIE L*a*b* color scale as related to standard source C alongside a white background on a reflection spectrophotometer. Results: Subsequent to the immersion of Meliodent heat-cured denture base resin materials within distilled water, the baseline color steadiness score was 6.16 ± 0.12, 6.12 ± 0.08 on the first day, 5.98 ± 0.06 on day 14 and 5.74 ± 0.14 on day 21. Within 2% alkaline glutaraldehyde the baseline color constancy mean value was 6.12 ± 0.28, 6.08 ± 0.04 on the first day, 5.04 ± 0.11 on day 14 and 4.22 ± 0.14 on day 21. Within 0.5% chlorhexidine gluconate the baseline color constancy mean value was 6.14 ± 0.09, 6.02 ± 0.12 on the first day, 5.38 ± 0.19 at 14th day and 4.84 ± 0.10 on day 21. In 0.5% sodium hypochlorite solution the baseline color steadiness mean value was 6.16 ± 0.18, 6.10 ± 0.06 on the first day, 4.98 ± 0.26 on 14th day and 3.14 ± 0.14 on day 21. ProBase Hot heat cure denture base resin materials after immersion in Distilled water delineated the baseline color constancy mean value was 6.48 ± 0.02, 6.34 ± 0.09 on the first day, 6.08 ± 0.14 on 14th day and 5.88 ± 0.07 on day 21. Within 2% alkaline glutaraldehyde the baseline color constancy mean value was 6.42 ± 0.16, 6.18 ± 0.11 on the first day, 5.12 ± 0.18 at 14th day and 4.24 ± 0.24 on day 21. Within 0.5% Chlorhexidine gluconate the baseline color steadiness mean value was 6.48 ± 0.10, 6.26 ± 0.08 on the first day, 5.48 ± 0.11 on 14th day and 4.88 ± 0.06 on day 21. In 0.5% sodium hypochlorite solution the baseline color steadiness mean value was 6.44 ± 0.12, 6.14 ± 0.08 on the first day, 4.98 ± 0.16 on 14th day, and 3.34 ± 0.06 on day 21. There was a statistically noteworthy difference amid the dissimilar time points in each of the three disinfectants. Conclusion: In the confines of the inherent limitations of this research, it can be inferred that the color steadiness of either denture base resins was enhanced following immersion in 0.5% chlorhexidine gluconate in pursuit by 2% alkaline glutaraldehyde as well as 0.5% sodium hypochlorite solution. Distilled water exerted the smallest amount of influence on the color change of the samples of denture base resins. Clinical significance: Techniques that help infection prevention influence denture disinfection. Currently, there is a dearth of commercially marketed agents that are specifically intended to disinfect dentures. Color constancy of the denture materials is an important parameter to be given due consideration while selecting a disinfectant. This would be a pivotal characteristic for practitioners to consider as they choose disinfectant solutions to disinfect dentures.