Aim: To analyze quantitatively the trends in publication and compare the scientific content published during 2011–2015 and 2016–2020. Materials and methods: An online search for all the different manuscripts published from 2011 to 2020 was performed electronically on the website of the Journal of Indian Prosthodontic Society (JIPS). The manuscripts were grouped into the following broader categories: Author, article grouping, original article subtype, prosthetic division, and statistical analysis. Results: The authors from private institutions showed higher publication trends than the authors from government institutions. The period 2016–2020 showed a higher number of publications with four or more authors. There was more original research published, followed by case reports. There was an increasing trend in a systematic review during 2016–2020 as compared to the period 2011–2015. There were a greater number of in vitro experimental studies published with a comparison of the means in the statistical analysis. There was more publication on materials and technology, followed by implants in the prosthetic division of articles. Conclusion: The analysis shows the overall progress of the journal explains the characteristics of the authors involved in the research, highlights the types of research done, statistical methods used, and important areas of research and trends in research in prosthodontics at a national level. Clinical significance: The publication trends will focus on the research thrust areas and the type of research done in the specialty, pointing out the gaps in the research and identifying the future course of action for authors and journals. It also helps for comparison with international publication trends in prosthodontics and provides information to prospective authors to focus research on the priority areas of the concerned journal for better acceptance.