The Journal of Contemporary Dental Practice

Register      Login

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue

Online First

Archive
Related articles

VOLUME 14 , ISSUE 6 ( November-December, 2013 ) > List of Articles

RESEARCH ARTICLE

Effect of Lycopene in the Treatment of Periodontal Disease: A Clinical Study

Sphoorthi Anup Belludi, Shiras Verma, Ruchi Banthia, Prashanth Bhusari, Simran Parwani, Sameer Kedia, SV Saiprasad

Citation Information : Belludi SA, Verma S, Banthia R, Bhusari P, Parwani S, Kedia S, Saiprasad S. Effect of Lycopene in the Treatment of Periodontal Disease: A Clinical Study. J Contemp Dent Pract 2013; 14 (6):1054-1059.

DOI: 10.5005/jp-journals-10024-1450

Published Online: 01-12-2013

Copyright Statement:  Copyright © 2013; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Purpose

Several epidemiologic studies have suggested a role of tomato products in decreasing the risk of the development of diseases related to oxidative stress (cancer and other chronic diseases). Oxidative stress may result in periodontal tissue damage either directly or indirectly. Lycopene, a powerful antioxidant and the main carotenoid in tomato products possesses the greatest quenching ability of singlet oxygen among the various carotenoids and is effective in protecting blood lymphocytes from NOO-radical damage. Hence, the aim of the present study is to compare the effect of systemically administered lycopene as an adjunct to scaling and root planing in patients with gingivitis and periodontitis.

Materials and methods

Twenty systemically healthy patients were involved in a randomized, double-blind, parallel study and based on their clinical signs were divided into two groups of mild to moderate periodontitis (A) and moderate gingivitis (B). The subjects under the groups A and B were randomly distributed between the two treatment groups: test group (n = 5), 4 mg lycopene/day for 2 weeks with oral prophylaxis (full mouth scaling and root planing (SRP) completed within 24 hours) and controls (n = 5), receiving only oral prophylaxis. Pre- and post-therapeutic periodontal parameters were evaluated.

Results

In group A, statistically significant improvement in CAL was reported in test group as compared to control group. In group B, the difference between pretreatment and post-treatment bleeding on probing scores was found to be statistically non-significant in both groups.

Conclusion

Results show that lycopene is a promising treatment modality as an adjunct to full mouth SRP of the oral cavity in patients with moderate periodontal disease.

Clinical significance

Modulation of the free radical production seems to be essential for the inhibition of tissue destruction, and treatment with antioxidants, like lycopene, which is the most potent among them will block the production of free ROS or its effects might prove to be therapeutically valuable.

How to cite this article

Belludi SA, Verma S, Banthia R, Bhusari P, Parwani S, Kedia S, Saiprasad SV. Effect of Lycopene in the Treatment of Periodontal Disease: A Clinical Study. J Contemp Dent Pract 2013;14(6):1054-1059.


PDF Share
  1. Lycopene: monograph. Alternative Medicine Review 2003;8:336-342.
  2. A review of the nonsurgical treatment of oral leukoplakia. International Journal of Dentistry 2010;1:1-10.
  3. Role of antioxidant lycopene in cancer and heart disease. Journal of the American College of Nutrition 2000;19:563-569.
  4. Protective effect of lycopene in cardiovascular disease. European Review for Medical and Pharmacological Sciences 2008;12:183-190.
  5. Antioxidants and periodontitis in 60 to 70 years old men. J Clin Periodontol 2009;36:843-849.
  6. Origin and physiological roles of inflammation. Nature 2008;454:428-435.
  7. Local and systemic total antioxidant capacity in periodontitis and health. J Clin Periodontol 2004;31:515-521.
  8. Phagocytes and Oxidative stress. American Journal of Medicine 2000;109:33-34.
  9. The role of reactive oxygen and antioxidant species in periodontal tissue destruction. Periodontol 2000, 2007;43:160-232.
  10. Inhibition of superoxide generation by human polymorphonuclear leucocytes with chlorhexidine. Its possible relation to periodontal disease. J Periodontol 1986;57:422-425.
  11. Efficacy of lycopene in the treatment of gingivitis: a randomised, placebo-controlled clinical trial. Oral Health Prev Dent 2007;5:327-336.
  12. Effects of Tempol, a membrane—permeable radical scavenger, in a rodent model periodontitis. J Clin Periodontol 2005;32:1062-1068.
  13. Antioxidative activities of some chemotherapeutics—a possible mechanism in reducing gingival inflammation. J Clin Periodontol 1994;21:680-683.
  14. Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Arch Biochem Biophys 1989;274:532-538.
  15. Carotenoids protect against cell membrane damage by the nitrogen dioxide radical. Nat Med 1995;1:98-99.
  16. Efficacy of oral lycopene in the treatment of oral leukoplakia. Oral Oncology 2004;40:591-596.
  17. Definitions of periodontal disease in research. J Clin Periodontol 2009;36:1-2.
  18. The relationship between tomato intake and congestive heart failure risk in periodontitis subjects. J Clin Periodontol 2004;31:574-580.
  19. The functions of tomato lycopene and its role in human health. Herbal Gram 2004;62:49-56.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.