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VOLUME 23 , ISSUE 10 ( October, 2022 ) > List of Articles

EDITORIAL

The SARS-CoV-2 Virus could Downregulate Dual Specificity Phosphatase-1 Expression in Oral Cancer: A Plausible Hypothesis that could Explain Oral Cancer Progression in the COVID-19 Pandemic and Post-pandemic Situation

Rajeswari Ramesh, Pearlcid Siroraj, Saranya Varadarajan, Thodur Madapusi Balaji

Keywords : COVID-19, Dual specificity phosphatase-1, Oral cancer, SARS-CoV-2

Citation Information : Ramesh R, Siroraj P, Varadarajan S, Balaji TM. The SARS-CoV-2 Virus could Downregulate Dual Specificity Phosphatase-1 Expression in Oral Cancer: A Plausible Hypothesis that could Explain Oral Cancer Progression in the COVID-19 Pandemic and Post-pandemic Situation. J Contemp Dent Pract 2022; 23 (10):963-964.

DOI: 10.5005/jp-journals-10024-3334

License: CC BY-NC 4.0

Published Online: 07-03-2023

Copyright Statement:  Copyright © 2022; The Author(s).


Abstract

This study explores the downregulation of Dual Specificity Phosphatase-1 (DUSP-1) expression in oral cancer progression during the pandemic and post-pandemic situations.


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  1. Herrera D, Serrano J, Roldán S, et al. Is the oral cavity relevant in SARS-CoV-2 pandemic? Clin Oral Investig 2020;24(8):2925–2930. DOI: 10.1007/s00784-020-03413-2.
  2. Zhou P, Yang X-L, Wang X-G, et al. Addendum: a pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 2020;588(7836):E6–E6. DOI: 10.1038/s41586-020-2951-z.
  3. Thevarajan I, Buising KL, Cowie BC. Clinical presentation and management of COVID-19. Med J Aust 2020;213(3):134–139. DOI: 10.5694/mja2.50698.
  4. Xu H, Zhong L, Deng J, et al. High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. Int J Oral Sci 2020;12(1):8. DOI: 10.1038/s41368-020-0074-x.
  5. Madapusi Balaji T, Varadarajan S, Rao USV, et al. Oral cancer and periodontal disease increase the risk of COVID 19? A mechanism mediated through furin and cathepsin overexpression. Med Hypotheses 2020;144:109936. DOI: 10.1016/j.mehy.2020.109936.
  6. Varadarajan S, Balaji TM, Sarode SC, et al. EMMPRIN/BASIGIN as a biological modulator of oral cancer and COVID-19 interaction: Novel propositions. Med Hypotheses 2020;143:110089. DOI: 10.1016/j.mehy.2020.110089.
  7. Caunt CJ, Keyse SM. No TiDual-specificity MAP kinase phosphatases (MKPs) Shaping the outcome of MAP kinase signalling. FEBS J 2013;280(2):489–504. DOI: 10.1111/j.1742-4658.2012.08716.x.
  8. Korhonen R, Turpeinen T, Taimi V, et al. Attenuation of the acute inflammatory response by dual specificity phosphatase 1 by inhibition of p38 MAP kinase. Mol Immunol 2011;48(15–16):2059–2068. DOI: 10.1016/j.molimm.2011.06.439.
  9. Zhang X, Hyer JM, Yu H, et al. No DUSP1 phosphatase regulates the proinflammatory milieu in head and neck squamous cell carcinoma. Cancer Res 2014;74(24):7191–7197. DOI: 10.1158/0008-5472.CAN-14-1379.
  10. Shen J, Zhang Y, Yu H, et al. Role of DUSP1/MKP1 in tumorigenesis, tumor progression and therapy. Cancer Med 2016;5(8):2061–2068. DOI: 10.1002/cam4.
  11. Saheb Sharif–Askari F, Saheb Sharif–Askari N, Goel S, et al. SARS-CoV-2 attenuates corticosteroid sensitivity by suppressing DUSP1 expression and activating p38 MAPK pathway. Eur J Pharmacol 2021;908:174374. DOI: 10.1016/j.ejphar.2021.174374.
  12. Dillibabu T, Varadarajan S, Balaji TM, et al. COVID-19 pandemic and lock-down protocols: Impact in an indian tertiary cancer center. Oral Oncol 2022;124:105484. DOI: 10.1016/j.oraloncology.2021.105484.
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