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VOLUME 15 , ISSUE 3 ( May-June, 2014 ) > List of Articles

RESEARCH ARTICLE

Evaluation of Serum Lipids and Lipoproteins as Prognosticators in Leukoplakia

BS Ganavi

Citation Information : Ganavi B. Evaluation of Serum Lipids and Lipoproteins as Prognosticators in Leukoplakia. J Contemp Dent Pract 2014; 15 (3):294-299.

DOI: 10.5005/jp-journals-10024-1531

Published Online: 01-06-2014

Copyright Statement:  Copyright © 2014; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Background

Oral cancer is the 8th most common cancer worldwide. Squamous cell carcinomas constitute 94% of all oral malignancies and are often preceded by leukoplakia. Despite many adjunctive techniques to monitor transformation of leukoplakia to oral squamous cell carcinoma (OSCC), the mortality rate is on the rise.

Incidentally, patients diagnosed with oral potentially malignant disorders (OPMDs) and oral cancers manifest with low choles-terol levels. Given a thought, hypolipidemia may be a useful adjunctive tool as it reflects the initial changes within the neo-plastic cells, thus giving a red alert in malignant transformation of leukoplakia at the earlier stage.

Aim

To evaluate the feasibility of serum lipid profile as an adjunct early marker for malignant transformation of leukoplakia to OSCC.

Objectives

To estimate the serum cholesterol, triglycerides and lipoprotein (HDL, LDL, VLDL) levels in patients with leukoplakia, OSCC and age matched healthy control group.

To compare the serum cholesterol, triglycerides and lipoprotein levels between patients of leukoplakia, OSCC and age matched healthy control group.

Materials and methods

The study group comprised of selected 30 individuals which included 10 each of histopathologically confirmed OSCC, leukoplakia and healthy controls. A written consent was taken from all of them, and a thorough case history was recorded and then venous blood was collected 12 hours post fasting and centrifuged. The serum cholesterol, triglycerides and HDL were estimated by enzymatic and colorimetric methods using commercially available kits — Roche/ Hitachi cobas systems. Chemistry assay QC procured from Bio-Rad was used as control. VLDL and LDL were derived from these values. Results were statistically analyzed using ANOVA and post hoc Tukey Test.

Results

Oral squamous cell carcinoma patients demonstrated significantly lower mean serum cholesterol level (151.60 mg/dl) than the control group (183.70 mg/dl). The mean cholesterol level in leukoplakia patients (173.90 mg/dl) was lower than that of control group (183.70 mg/dl) but higher than that of the OSCC group (151.60 mg/dl) with no statistical significance.

Conclusion

Convenience, universal availability, patient compatibility and simplicity being the merits of serum lipid profile make it a feasible adjunctive prognosticator in leukoplakic patients.

How to cite this article

Ganavi BS, Patil S, Rao RS. Evaluation of Serum Lipids and Lipoproteins as Prognosticators in Leukoplakia. J Contemp Dent Pract 2014;15(3):294-299.


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  1. A clinicopathological study of oral cancers. Biomedica 2011;27(Jan-June):29-32.
  2. Oral and maxillofacial pathology. 3rd ed. Missouri: Saunders; 2009. p. 356-366.
  3. Oral medicine and pathology: a guide to diagnosis and management. 1st ed. New Delhi: Jaypee Brothers Medical Publishers; 2014. p. 268-329.
  4. Harper's illustrated Biochemistry. 27th ed. Asia: The McGraw-Hill Companies Inc; 2003. p. 121-132.
  5. How cells handle cholesterol. Science 2000;290(5497):1721-1726.
  6. Role of cholesterol and lipid organization in disease. Nature 2005;438(7068):612-621.
  7. Serum lipids and lipoprotein disorders in cancer patients. Cancer 1987;60(12):3065-3070.
  8. Alterations in plasma lipid profile patterns in head and neck cancer and oral precancerous conditions. Indian J Cancer 2004;41(1):25-31.
  9. Lipid profile in oral submucous fibrosis. Lipids in Health and Disease 2009;8:29.
  10. Evaluation of correlation of serum lipid profile in patients with oral cancer and precancer and its association with tobacco abuse. J Oral Pathol Med 2010;39:141-148.
  11. Alterations in serum lipid profile patterns in oral cancer and oral precancerous lesions and conditions—a clinical study. Indian J Dentist 2011;2(2):1-7.
  12. Serum lipid profile in patients with oral tobacco habits and oral precancer lesions and conditions. Web Med Central Oral Med 2013;4(2):WMC004034.
  13. Maryland: NHLBI Health Information Network; 2001 (cited 2013 Sep 30). Available at: http://www.nhlbi.nih.gov/guidelines/cholesterol/atglance.htm.
  14. Cancer of the oral cavity: a comparison between institutions in a developing and a developed nation. Head Neck 2004;26:31-38.
  15. Oral Oncol Eur J Cancer Part B 1992;28B:37-38.
  16. Exploring the reasons for delay in treatment of oral cancer. J Am Dent Assoc 2008;139:1346-1352.
  17. Strengthening the prevention of oral cancer: the WHO perspective. Community Dent Oral Epidemiol 2005;33:397-399.
  18. Incidence rates of oral cancer and natural history of oral precancerous lesions in a 10 years follow-up study of Indian villagers. Comm Dent Oral Epidemiol 1980;8(6):283-333.
  19. Oral leukoplakia: a proposal for uniform reporting. Oral Oncol 2002;38:521-526.
  20. DNA ploidy measurement in oral leukoplakia: different results between flow and image cytometry. Oral Oncol 2012;48:636-640.
  21. Involvement of potential pathways in malignant transformation from oral leukoplakia to oral squamous cell carcinoma revealed by proteomic analysis. BMC Genomics 2009;10:383.
  22. Predicting cancer development in oral leukoplakia: ten years of translational research. Clin Cancer Res 2000;6:1702-1710.
  23. Textbook of biochemistry. 3rd ed. New Delhi: Jaypee Brothers Medical Publishers (P) Ltd; 2001, p. 133-146.
  24. Cholesterol. New York: Marcel Dekker Inc; 1977. p. 79-103.
  25. Plasma lipids and mortality: a source of error. Lancet 1980 Mar;1(8167):523-526.
  26. Malignancyassociated dyslipidemia. Open Cardiovasc Med J 2011;5:35-40.
  27. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the women's health initiative randomized controlled trial. JAMA 2004;291:1701-1712.
  28. Serum cholesterol and cancer risk: an epidemiologic perspective. Annu Rev Nutr 1992;12:391-416.
  29. Cancer incidence by levels of cholesterol. JAMA 1981;245:247-252.
  30. Review of the epidemiological evidence for a possible relationship between hypocholesterolemia and cancer. Cancer Res 1983;43(5):2503s-2507s.
  31. A prospective follow-up of study of 570 patients with oral lichen planus: persistence, remission, and malignant transformation. Oral Surg Oral Med Oral Pathol 1985;60:30-34.
  32. Late determinants of cancer. Pathol Res Pract 1984;179:74-80.
  33. Dietary cholesterol, serum cholesterol and colon cancer: a review. Adv Exp Med Biol 1986;206:137-152.
  34. Lipoprotein cholesterol, vitamin A, and vitamin E in an alcoholic population. Cancer 1986;57:1798-1802.
  35. Dietary and endogenous cholesterol and human cancer. Epidemiol Rev 1984;6:192-216.
  36. Serum retinol and the inverse relationship between serum cholesterol and cancer. Br Med J 1982;284(6310):152-154.
  37. Association of low plasma cholesterol with mortality for cancer at various sites in men 17-year follow-up of the prospective basel study. Am J Clin Nutr 2000;71(2):569-574.
  38. Retinol carotene and the cancer/cholesterol association. Lancet 1981;1(8234):1371-1372.
  39. Determination of fluorescence quenching of the environment of DNA cross-links made by malondialdehyde. Biochim Biophys Acta 1983;740(2):185-189.
  40. Comparison of the mutagenicity of malondialdehyde and the side-products formed during its chemical synthesis. Cancer Res 1980;40(2):276-282.
  41. Carcinogenic effect of cholesterol in mice. Proc Soc Exp Biol Med 1966;121(1):168-171.
  42. Genesis of breast cancer in Japanese a possible relationship between sex hormone-binding globulin (SHBG) and serum lipid components. Breast Cancer Res Treat 1991;18(1):527-529.
  43. Hypocholesterolemia in acute myelogenous leukemia. Association between disease activity and plasma low density lipoprotein cholesterol concentrations. Cancer 1986;58(6):1361-1365.
  44. Blood lipid profiles in children with acute lymphoblastic leukemia. Cancer 1998;83(2):379-384.
  45. Cancer and low level of plasma cholesterol: the relevance of cholesterol precursors and products to incidence of cancer. Prev Med 1999;29(5):383-390.
  46. Total serum cholesterol and cancer mortality in a middle-aged male population. Am J Epidemiol 1980;112(3):388-394.
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