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VOLUME 16 , ISSUE 2 ( February, 2015 ) > List of Articles


Serum and Saliva MMP-3 in Patients with OLP and Oral SCC

Iraj Mirzaii-Dizgah, Farzaneh Agha-Hosseini, Nima Mahboobi, Shiva Shirazian, Iraj Harirchi

Citation Information : Mirzaii-Dizgah I, Agha-Hosseini F, Mahboobi N, Shirazian S, Harirchi I. Serum and Saliva MMP-3 in Patients with OLP and Oral SCC. J Contemp Dent Pract 2015; 16 (2):107-111.

DOI: 10.5005/jp-journals-10024-1645

Published Online: 01-02-2015

Copyright Statement:  Copyright © 2015; The Author(s).



Matrix metalloproteinase-3 (MMP-3) plays a key role in development of cancer. The purpose of this study was to assess MMP-3 in the serum and saliva of patients with oral lichen planus (OLP) and oral squamous cell carcinoma (OSCC).

Materials and methods

Thirty patients with OLP (8 reticular and 22 erosive forms), and 20 patients with OSCC (6 in low stage and 14 in advanced stage), were enrolled in this study, conducted at the Cancer Department, Clinic of Oral Medicine, Tehran University of Medical Sciences. The serum and saliva MMP-3 was assayed by ELISA method. Statistical analysis of the Student's t-test, ANOVA and Pearson correlation coefficient was performed. The mean saliva and serum levels of MMP-3 were significantly higher in patients with OSCC compared with OLP.


The serum and saliva MMP-3 concentrations increased from reticular form of OLP to erosive form of OLP, and increased further to low stage of OSCC and advanced stage of OSCC. Serum MMP-3 correlated significantly with unstimulated (r = 0.310, p = 0.038) and stimulated (r = 0.365, p < 0.026) saliva MMP-3.


Serum and saliva MMP-3 levels appear associated with OLP and OSCC.

How to cite this article

Agha-Hosseini F, Mirzaii-Dizgah I, Mahboobi N, Shirazian S, Harirchi I. Serum and Saliva MMP-3 in Patients with OLP and Oral SCC. J Contemp Dent Pract 2015;16(2):107-111.

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