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VOLUME 16 , ISSUE 6 ( June, 2015 ) > List of Articles


Evaluation of Microvascularity by CD34 Expression in Esophagus and Oral Squamous Cell Carcinoma

Donia Sadri, Fatemeh Shahsavari, Sareh Farhadi, Marzieh Sedehi

Citation Information : Sadri D, Shahsavari F, Farhadi S, Sedehi M. Evaluation of Microvascularity by CD34 Expression in Esophagus and Oral Squamous Cell Carcinoma. J Contemp Dent Pract 2015; 16 (6):458-462.

DOI: 10.5005/jp-journals-10024-1706

Published Online: 01-11-2015

Copyright Statement:  Copyright © 2015; The Author(s).



The present study was scheduled to evaluate microvascularity by CD34 expression in esophagus and oral squamous cell carcinoma.

Materials and methods

This study was scheduled using 40 paraffin blocked samples including 20 of oral SCC and 20 of esophagus ones and Immunohistochemical staining was conducted using CD34 monoclonal antibody. Exact fisher test was used to evaluate frequency of expression between two studied groups.


There was significant correlation between age and tumor size with CD34 expression in oral SCC samples (p < 0.05) and no significant correlation between sex and tumor differentiation level (grading) (p > 0.05). Also, there was no significant correlation between age, sex, tumor size and tumor differentiation level (grading) with CD34 expression in esophagus SCC samples (p > 0.05). There was no significant difference of CD34 expression frequency in oral and esophagus SCC (p = 0/583). Finally, CD34 expression was reported ‘high’ for major cases of esophagus and oral SCCs.


It seems, other angiogenetic or nonangiogenetic factors except CD34 may play more important role and explain the different clinical behavior of SCC at recent different locations.

Clinical significance

Other factors would be considered along with CD34 expression to interpret different clinical behavior of SCC at recent different locations.

How to cite this article

Shahsavari F, Farhadi S, Sadri D, Sedehi M, Evaluation of Microvascularity by CD34 Expression in Esophagus and Oral Squamous Cell Carcinoma. J Contemp Dent Pract 2015;16(6):458-462.

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