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VOLUME 16 , ISSUE 11 ( November, 2015 ) > List of Articles

RESEARCH ARTICLE

Antimicrobial Potential of Momordica charantia L. against Multiresistant Standard Species and Clinical Isolates

Rennaly de Freitas Lima, Edja Maria Melo de Brito Costa, José Hardman Sátiro de Lucena Filho, Ana Claudia Dantas de Medeiros, Jozinete Vieira Pereira, Ana Flávia Granville-Garcia

Citation Information : de Freitas Lima R, de Brito Costa EM, de Lucena Filho JH, de Medeiros AC, Pereira JV, Granville-Garcia AF. Antimicrobial Potential of Momordica charantia L. against Multiresistant Standard Species and Clinical Isolates. J Contemp Dent Pract 2015; 16 (11):854-858.

DOI: 10.5005/jp-journals-10024-1770

Published Online: 01-11-2015

Copyright Statement:  Copyright © 2015; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Aim

The aim of the present study was to evaluate the antibacterial and antifungal potential in vitro of Momordica charantia L. against the microorganisms of clinical interest (standard strains and multiresistant isolates) in order to aggregate scientific information in relation to its use as a therapeutic product.

Materials and methods

M. charantia L. plant material was acquired in municipality of Malta, Paraiba, Brazil. The extract was obtained through maceration, filtration and then concentrated under reduced pressure in a rotary evaporator, resulting in a dough, and was then dried in an oven for 72 hours at 40°C. Antimicrobial action of ethanolic extract of seed M. charantia L. was evaluated based on the minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and minimum fungicidal concentration (MFC) against standard strains of bacteria, isolates multiresistant bacteria and Candida species, by microdilution in broth method.

Results

All organisms were sensitive to the extract, being considered strong antimicrobial activity (MIC and MBC/MFC < 0.125 mg/ml).

Conclusion

The M. charantia L. showed strong antimicrobial potential, with bactericidal and fungicidal profile, there is the prospect to constitute a new therapeutic strategy for the control of infections, particularly in multiresistant strains.

Clinical significance

The use of medicinal plants in treatment of infectious processes have an important function nowadays, due to the limitations of the use of synthetic antibiotics available, related specifically to the microbial resistance emergence.

How to cite this article

de Lucena Filho JHS, de Freitas Lima R, de Medeiros ACD, Pereira JV, Granville-Garcia AF, de Brito Costa EMM. Antimicrobial Potential of Momordica charantia L. against Multiresistant Standard Species and Clinical Isolates. J Contemp Dent Pract 2015;16(11):854-858.


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