The Journal of Contemporary Dental Practice

Register      Login

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue

Online First

Archive
Related articles

VOLUME 17 , ISSUE 1 ( January, 2016 ) > List of Articles

RESEARCH ARTICLE

Adjunctive Systemic Antimicrobial Therapy vs Asepsis in Conjunction with Guided Tissue Regeneration: A Randomized, Controlled Clinical Trial

Mahmoud Abu-Ta'a

Citation Information : Abu-Ta'a M. Adjunctive Systemic Antimicrobial Therapy vs Asepsis in Conjunction with Guided Tissue Regeneration: A Randomized, Controlled Clinical Trial. J Contemp Dent Pract 2016; 17 (1):3-6.

DOI: 10.5005/jp-journals-10024-1794

Published Online: 01-01-2016

Copyright Statement:  Copyright © 2016; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Aim

This randomized clinical trial compares the usefulness of adjunctive antibiotics, while strict asepsis was followed during periodontal surgery involving guided tissue regeneration.

Materials and methods

Two groups of 20 consecutive patients each with advanced periodontal disease were randomly assigned to treatment. They displayed one angular defect each with an intrabony component ≥3 mm, probing pocket depth and probing attachment level (PAL) ≥7 mm. Test group included 13 males, mean age 60 years, treated with enamel matrix derivative (EMD) and demineralized freeze-dried bone allograft with modified papilla preservation technique, received oral amoxicillin 1 gm, 1 hour preoperatively and 2 gm for 2 days postoperatively. Control group included 10 males, mean age 57 years, treated with EMD and demineralized freeze-dried bone allograft with modified papilla preservation technique, received no antibiotics.

Outcome measures were clinical attachment level (CAL) gain, residual periodontal pocket depth (res. PD), gingival recession (GR), bleeding on probing (BOP), adverse events and postoperative complications.

Patients were followed up to 12 months after periodontal surgery involving guided tissue regeneration.

Results

There were no significant differences between both groups for CAL gain, res. PD, GR, BOP nor other clinical parameters, though patients’ subjective perception of postoperative discomfort was significantly smaller in the group receiving antibiotics.

Conclusion

Antibiotics do not provide significant advantages concerning clinical periodontal parameters nor concerning postoperative infections in case of proper asepsis. It does, on the contrary, reduce postoperative discomfort.

Clinical significance

Regarding the results of this study, adjunctive systemic antibiotics in combination with guided tissue regeneration may be useful in reducing postoperative discomfort but may not be helpful for improving periodontal regeneration outcomes.

How to cite this article

Abu-Ta'a M. Adjunctive Systemic Antimicrobial Therapy vs Asepsis in Conjunction with Guided Tissue Regeneration: A Randomized, Controlled Clinical Trial. J Contemp Dent Pract 2016;17(1):3-6.


PDF Share
  1. Regeneration of periodontal tissues: guided tissue regeneration. Dent Clin North Am 2010 Jan;54(1):73-92.
  2. Are surgical scrubbing and pre-operative disinfection of the skin in orthopaedic surgery reliable? Knee Surg Sports Traumatol Arthrosc 2006 Jan;14(1):27-31.
  3. R. Implants and infections with special reference to oral bacteria. J Clin Periodontol 1990 Aug;17(7 Pt 2):516-524.
  4. Adverse clinical and economic outcomes attributable to methicillin resistance among patients with Staphylococcus aureus surgical site infection. Clin Infect Dis 2003 Mar 1;36(5):592-598.
  5. The influence of preoperative antibiotics on success of endosseous implants up to and including stage II surgery: a study of 2,641 implants. J Oral Maxillofac Surg 1997 Dec;55 (12 Suppl 5):19-24.
  6. Asepsis during periodontal surgery involving oral implants and the usefulness of peri-operative antibiotics: a prospective, randomized, controlled clinical trial. J Clin Periodontol 2008 Jan;35(1):58-63.
  7. The incidence of clinical infection after periodontal surgery. A retrospective study. J Periodontol 1983 Jul;54(7):441-443.
  8. Complete nose coverage to prevent airborne contamination via nostrils is unnecessary. Clin Oral Implants Res 1997 Dec;8(6):512-516.
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.