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VOLUME 17 , ISSUE 7 ( July, 2016 ) > List of Articles


Evaluation of Inflammatory Response to Endodontic Sealers in a Bone Defect Animal Model

Miriam Z Scelza, Carlos AM Campos, Pantaleo Scelza, Caroline SR Adeodato, Igor B Barbosa, Fernando de Noronha, Victor Montalli, Marcelo Napimoga, Vera C de Araújo,1, Gutemberg G Alves

Citation Information : Scelza MZ, Campos CA, Scelza P, Adeodato CS, Barbosa IB, de Noronha F, Montalli V, Napimoga M, de Araújo,1 VC, Alves GG. Evaluation of Inflammatory Response to Endodontic Sealers in a Bone Defect Animal Model. J Contemp Dent Pract 2016; 17 (7):536-541.

DOI: 10.5005/jp-journals-10024-1885

Published Online: 01-07-2016

Copyright Statement:  Copyright © 2016; The Author(s).



The aim of this study was to evaluate the inflammatory response to MTA Fillapex, AH Plus, and Pulp Canal Sealer Extensive Work Time (EWT), in a murine bone defect grafting model.

Materials and methods

Bilateral mandibular critical defects were produced in 45 Wistar rats with a trephine bur#2 and filled with the endodontic sealers. After 7, 14, and 28 days, the rats were euthanized and their jaws were histologically prepared.


For the 7-day group, no statistical significance was observed among all studied groups (p > 0.05), and high levels of inflammatory infiltrate were detected. After 14 and 28 days, Pulp Canal Sealer EWT showed statistically lower inflammatory response in comparison to other sealers (p < 0.05) except for the control group (no sealers).


Pulp Canal Sealer EWT presented the lowest levels of inflammatory response. The critical defect grafting model was an effective method to detect differences among differences on the biological response to endodontic sealers.

Clinical significance

Knowing the biocompatibility of endodontics sealers that will be used in filling the root canal.

How to cite this article

Scelza MZ, Campos CAM, Scelza P, Adeodato CSR, Barbosa IB, de Noronha F, Montalli V, Napimoga M, de Araújo VC, Alves GG. Evaluation of Inflammatory Response to Endodontic Sealers in a Bone Defect Animal Model. J Contemp Dent Pract 2016;17(7):536-541.

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