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VOLUME 17 , ISSUE 8 ( August, 2016 ) > List of Articles

RESEARCH ARTICLE

Remineralizing Effect of Topical NovaMin and Nanohydroxyapatite on Caries-like Lesions in Primary Teeth

Roza Haghgoo, Motahare Ahmadvand, Sareh Moshaverinia

Citation Information : Haghgoo R, Ahmadvand M, Moshaverinia S. Remineralizing Effect of Topical NovaMin and Nanohydroxyapatite on Caries-like Lesions in Primary Teeth. J Contemp Dent Pract 2016; 17 (8):645-649.

DOI: 10.5005/jp-journals-10024-1905

Published Online: 01-12-2016

Copyright Statement:  Copyright © 2016; The Author(s).


Abstract

Introduction

NovaMin is a synthetic mineral compound composed of calcium, sodium, phosphorus, and silica. It releases crystalline hydroxyl-carbonate apatite (HCA), which structurally resembles the minerals naturally found in the teeth. Nanohydroxyapatite (NHA) is a biocompatible compound with high affinity for tooth enamel. NHA particles morphologically resemble dental enamel apatite crystals. Considering the efficacy of remineralizing agents and the importance of conservative preventive measures, this study aimed to compare the remineralizing effects of NovaMin and NHA on caries-like lesions in primary teeth.

Materials and methods

This in vitro experimental study was conducted on 30 sound human primary anterior teeth with no cracks or fractures. The surface microhardness (SMH) of each tooth was measured at baseline using a Vickers microhardness tester. The teeth were then subjected to remineralization/ demineralization cycles, and artificial caries lesions were created in them. The SMH of each tooth was measured again and the teeth were then randomly treated with toothpastes containing NovaMin or 10% NHA powder for 2 minutes daily for a period of 5 days. The SMH of each was again measured afterward. Data were statistically analyzed using independent t-tests and Mann–Whitney U tests.

Results

The mean SMH was found to be higher in the teeth treated with NovaMin toothpaste (422.67 kgf/mm2) than in the teeth treated with NHA (384.2 kgf/mm2); However, this difference was not statistically significant.

Conclusion

Both NHA and NovaMin were effective for remineralization of caries-like lesions of primary teeth and no significant difference was detected in their efficacy.

How to cite this article

Haghgoo R, Ahmadvand M, Moshaverinia S. Remineralizing Effect of Topical NovaMin and Nano-hydroxyapatite on Caries-like Lesions in Primary Teeth. J Contemp Dent Pract 2016;17(8):645-649.


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  1. Effect of a CPP-ACP agent on the demineralization and remineralization of dentin in vitro. J Dent 2007 Aug;35(8):695-698.
  2. Remineralization effect of topical NovaMin versus sodium fluoride (1.1%) on caries-like lesions in permanent teeth. J Dent (Tehran) [S6] 2012 Winter;9(1):68-75.
  3. Effect of nano-hydroxyapatite concentration on remineralization of initial enamel lesion in vitro. Biomed Mater 2009 Jun;4(3):034104.
  4. Comparative toxicity of nano-scale Tio2, Sio2 and Zno water suspensions. Water Sci Technol 2006;54(11-12):327-334.
  5. Antibacterial activity of ZnO nanoparticle suspensions on a board spectrum of microorganisms. FEMS Microbiol Lett 2008 Feb;279(1):71-76.
  6. Evaluation of the effect of nanohydroxyapatite on erosive lesions of the enamel of permanent teeth following exposure to soft beer. Scientific Res Essays 2011 Nov;6(28):5933-5936.
  7. The effect of nanohydroxyappatite solution on the permanent tooth remineralization following exposure to soft beer (in situ). J Dental Med 2015;27(4):233-240.
  8. Evaluation of Iranian toothpaste containing different concentration of nanohydroxyapatite on the remineralization of incipient carious lesions: In vitro. J Dental Med 2015;27(4):254-258.
  9. Comparison of nano hydroxy apatite and sodium fluoride mouthrinse for remineralization of incipient caries lesions. J Dent (Tehran) 2014 Jul;11(4):406-410.
  10. Potential agents to control enamel caries-like lesions. J Dent 2009 Oct;37(10):786-790.
  11. Anti-caries potential of commercial dentifrices as determined by fluoridation and remineralization efficiency. J Contemp Dent Pract 2007 Nov;8(7):1-10.
  12. Studies on the cariostatic mechanisms of fluoride. Int Dent J 1994 Jun;44(3 Suppl 1): 263-273.
  13. Primary preventive dentistry. 7th ed. New Jersey; Pearson Education Inc.: 2009. Chaps 3,8,12. pp. 30, 138, 246-249.
  14. ; Andersson, O. Bioactive glasses. In: Hench, L.L; Wilson, J. Introduction to bioceramics. Singapore; World Scientific. p. 45-47.
  15. An analytical model for the dissolution of different particle size samples of Bioglass in TRIS buffered solution. Biomaterials 2005 Aug;26(24):4903-4911.
  16. Enamel and dentin remineralization by nano-hydroxyapatite toothpastes. J Dent 2011 Jun;39(6):430-437.
  17. New approaches to enhanced remineralization of tooth enamel. J Dent Res 2010 Nov;89(11):1187-1197.
  18. Remineralization potential of fully demineralized dentin infiltrated with silica and hydroxyapatite nanoparticles. Dent Mater 2014 Mar;30(3):249-262.
  19. In vitro human enamel remineralization using bioactive glass containing dentifrice. Presented at IADR/AADR/CADR 83rd General Session, 2005 March 9-12.
  20. In vitro root caries remineralization by NovaMin dentifrices. Presented at 42nd annual meeting of IADR-Continental European and Israeli Divisions, 2007 Sept 26-29th.
  21. Clinical efficacy of casein derivatives: a systematic review of the literature. J Am Dent Assoc 2008 Jul;139(7):915-924.
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