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VOLUME 17 , ISSUE 11 ( November, 2016 ) > List of Articles

RESEARCH ARTICLE

A Case–control Study for the Assessment of Correlation of Denture-related Sores and Oral Cancer Risk

Javed Khan, B Vikas Prasad, Gauri S Kakatkar, Maulik Patel, Preet Jain

Citation Information : Khan J, Prasad BV, Kakatkar GS, Patel M, Jain P. A Case–control Study for the Assessment of Correlation of Denture-related Sores and Oral Cancer Risk. J Contemp Dent Pract 2016; 17 (11):930-933.

DOI: 10.5005/jp-journals-10024-1956

Published Online: 01-03-2017

Copyright Statement:  Copyright © 2016; The Author(s).


Abstract

Introduction

Oral cancer is one of the most common cancers in the world. Although multifactorial, the exact pathogenesis of oral cancer is still unclear. Apart from tobacco chewing and smoking, chronic long-term irritation by ill-fitting denture is also said to be an important risk factor for the development of oral cancer. Literature quotes some amount of evidence that correlates long-term denture irritation as a risk factor for the development of oral cancer. Hence, we analyzed the correlation of denturerelated sores as a risk factor for the development of oral cancer.

Materials and methods

The present case–control study included 140 newly diagnosed oral cancer cases and 140 patients as the control healthy group. One-hour questionnaire was framed and was conducted to the control group and the study group by 10 experienced interviewers who were trained for such type of analysis. Assessment of the patients’ socioeconomic status, cigarette smoking habit, alcohol drinking habit, and oral health status was done and compared on the two study groups. Logistic regression models along with multivariate models were used for the assessment of the results.

Results

In the control group and the cancer patient group, total of 140 new cancer cases and 140 subjects were included. Out of 140 patients in the cancer group, 16 were nonsmokers, while 110 smoked cigarette in the cancer patient group. As far as alcohol consumption is concerned, 42 patients in the control group and 102 patients in the oral cancer group were chronic heavy drinkers. Fried food intake was high in both the groups. Significant correlation was obtained while comparing the heavy smokers, heavy alcohol consumers, and oral health status in both the study groups.

Conclusion

Our results favor the hypothesis that positive correlation exists between oral cancer risk and recurrent denture sores.

Clinical significance

People wearing denture prosthesis should be periodically visualized for identification of any mucosal alteration or changes at the earliest.

How to cite this article

Jain P, Jain M, Prasad BV, Kakatkar GS, Patel M, Khan J. A Case–control Study for the Assessment of Correlation of Denture-related Sores and Oral Cancer Risk. J Contemp Dent Pract 2016;17(11):930-933.


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  1. A review of global cancer burden: trends, challenges, strategies, and a role for surgeons. J Surg Oncol 2013 Feb;107(2):221-226.
  2. Inverse association between tooth brushing and upper aerodigestive tract cancer risk in a Japanese population. Head Neck 2011 Nov;33(11):1628-1637.
  3. Oral status, oral infections and some lifestyle factors as risk factors for oral and oropharyngeal squamous cell carcinoma: a population-based case-control study in southern Sweden. Acta Otolaryngol 2005 Dec;125(12):1327-1336.
  4. Relationship between chronic trauma of the oral mucosa, oral potentially malignant disorders and oral cancer. J Oral Pathol Med 2010 Aug;39(7):513-517.
  5. J Prosthetic Dent 2005 Jul;94(1):10-92.
  6. Denture wearing and oral cancer. J Prosthetic Dent 1984 Aug;52(2):164-166.
  7. Head and neck cancer: a global perspective on epidemiology and prognosis. Anticancer Res 1998 Nov-Dec;18(6B):4779-4786.
  8. Relationship between dental factors and risk of upper aerodigestive tract cancer. Oral Oncol 1998 Jul;34(4):184-291.
  9. Dentition, diet, tobacco and alcohol in the epidemiology of oral cancer. J Natl Cancer Inst 1977 Dec;59(6):1611-1616.
  10. Fat food habitual intake and risk of oral cancer. Oral Oncol 2004 Oct;40(9):925-931.
  11. Monographs on the evaluation of carcinogenic risks to humans: tobacco smoking. Lyon: IARC; 1986.
  12. Monographs on the evaluation of carcinogenic risks to humans: alcohol drinking. Lyon: IARC; 1988.
  13. Available from: http://www.odontologia.com.br/artigos.asp?id=174&idesp=19&ler=s on June 25th 2005. Saú de oral do idoso.
  14. Projeto SB Brasil 2003-Condicõ es de saú de bucal da populacão brasileira 2002–2003. Brasília-DF: resultados principais. 2004.
  15. Recurrent sores by ill-fitting dentures and intra-oral squamous cell carcinoma in smokers. J Public Health Dent 2010 Winter;70(1):52-57.
  16. Are recurrent denture-related sores associated with the risk of oral cancer? A case control study. Rev Bras Epidemiol 2013 Sep;16(3):705-715.
  17. Risk factors in oral and oropharyngeal squamous cell carcinoma: a population-based case-control study in southern Sweden. Swed Dent J Suppl 2005;(179):1-66.
  18. Ill-fitting dentures and oral cancer: a meta-analysis. Oral Oncol 2014 Nov;50(11):1058-1061.
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