Aim: To perform a bibliometric study of periodontal disease and Alzheimer's disease (AD) focusing on trends, collaborative efforts, and emerging patterns. Materials and methods: From January 2018 to May 2024, an observational study was carried out utilizing metadata extracted from the Scopus database. A search methodology, specifically designed for this database, was developed using MeSH terms combined with Boolean operators such as “AND” and “OR”. The Bibliometrix tool was employed to facilitate the study, using indicators including the number of citations and publications, the authorship of the publication, the country of origin, the year of publication, the type of publication, the H-index, WorldMap, Sankey diagram, keyword analysis, topic evolution, and scientific findings. Results: A total of 50.7 and 27.3% of the publications were in Q1 and Q2 quartile journals. The University of Central Lancashire has the most publications (17), but the University of California at San Francisco has the highest impact (1545 citations per publication). The journal Periodontology 2000 had a total of 643 citations per publication. Sim Kaur Singhrao (16) and Ingar Olsen (10) were the authors with the most publications, whereas Eric C Reynolds had the highest impact with 1,300 citations. Conclusions: This bibliometric study found a gradual growth in publications, with the highest number of studies during 2021 and 2022, followed by a decrease in subsequent years, with Q1 and Q2 journals predominating. In terms of scientific productivity, the United States is the leading country in this area of research. The journal Periodontology 2000 had the highest number of citations, demonstrating the particular interest of periodontology in studying the association between periodontal disease and systemic diseases. Clinical significance: The present study is significant because the relationship between periodontitis and Alzheimer is currently considered a novel multidisciplinary research opportunity, given that it includes both medical and dental specialties. This research also provides a valuable contribution to academics, universities, and research centers because it will allow us to understand trends and new research horizons and identify the most productive authors.