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VOLUME 18 , ISSUE 8 ( August, 2017 ) > List of Articles


Antimicrobial and Antiproliferative Activity of Bauhinia forficata Link and Cnidoscolus quercifolius Extracts commonly Used in Folk Medicine

Edja Maria Melo de Brito Costa, Pedro L Rosalen, Jozinete V Pereira, Erika P Alves, Rennaly de F Lima, Carolina M de Almeida, Irlan A Freires, Ana LTG Ruiz, Ana F Granville-Garcia, Gustavo P Godoy

Citation Information : de Brito Costa EM, Rosalen PL, Pereira JV, Alves EP, de F Lima R, de Almeida CM, Freires IA, Ruiz AL, Granville-Garcia AF, Godoy GP. Antimicrobial and Antiproliferative Activity of Bauhinia forficata Link and Cnidoscolus quercifolius Extracts commonly Used in Folk Medicine. J Contemp Dent Pract 2017; 18 (8):635-640.

DOI: 10.5005/jp-journals-10024-2098

Published Online: 01-11-2017

Copyright Statement:  Copyright © 2017; The Author(s).



Bauhinia forficata and Cnidoscolus quercifolius plants are commonly used in folk medicine. However, few studies have investigated their therapeutic potential.


Herein, we evaluated the antimicrobial activity of B. forficata and C. quercifolius extracts against microorganisms of clinical relevance and their antiproliferative potential against tumor cells.

Materials and methods

The following tests were performed: Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC)/minimum fungicidal concentration (MFC), inhibition of biofilm adhesion, and effects on cell morphology. Antiproliferative tests were carried out with human keratinocytes and six tumor lines.


Bauhinia forficata showed antimicrobial activity only against C. albicans with MIC of 15.62 μg/mL and MFC higher than 2000 μg/mL. It also inhibited biofilm adhesion and caused alterations in cell morphology. Cnidoscolus quercifolius showed no significant activity (MIC > 2.0 mg/mL) against the strains. Bauhinia forficata and C. quercifolius extracts showed cytostatic activity against the tumor cells.


Bauhinia forficata has promising anti-Candida activity and should be further investigated for its therapeutic potential.

Clinical significance

The use of medicinal plants in the treatment of infectious processes has an important nowadays, due to the limitations of the use of synthetic antibiotics available, related specifically to the microbial resistance emergence.

How to cite this article

Alves EP, de F Lima R, de Almeida CM, Freires IA, Rosalen PL, Ruiz ALTG, Granville-Garcia AF, Godoy GP, Pereira JV, de Brito Costa EMM. Antimicrobial and Antiproliferative Activity of Bauhinia forficata Link and Cnidoscolus quercifolius Extracts commonly Used in Folk Medicine. J Contemp Dent Pract 2017;18(8):635-640.

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