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VOLUME 18 , ISSUE 9 ( September, 2017 ) > List of Articles


Growth and Development of Dentofacial Complex influenced by Genetic and Environmental Factors using Monozygotic Twins

KK Manjusha, K Jyothindrakumar, A Nishad, K Madhav Manoj

Citation Information : Manjusha K, Jyothindrakumar K, Nishad A, Manoj KM. Growth and Development of Dentofacial Complex influenced by Genetic and Environmental Factors using Monozygotic Twins. J Contemp Dent Pract 2017; 18 (9):754-758.

DOI: 10.5005/jp-journals-10024-2121

Published Online: 01-12-2017

Copyright Statement:  Copyright © 2017; The Author(s).



The purpose of this study was to determine the possible effects of genetic and environmental factors on dentofacial complex using monozygotic twins.

Materials and methods

The study sample was made of 21 pairs of monozygotic twins (14 female pairs and seven male pairs) between 10 and 25 years. Pretreatment lateral cephalograms were used which were traced and digitized, and various landmarks to determine the anteroposterior and vertical proportions were marked. Samples were divided into two groups. The correlation between groups was found by calculating Pearson's product moment correlation coefficients.


The range of the correlation coefficient was from 0.705 to 0.952. Gonial angle showed the highest correlation coefficient (0.952), while saddle angle showed the lowest correlation coefficient (0.705).


The growth and development of craniofacial complex is under mutifactorial control. However, genetic influences do tend to play a dominant role.

Clinical significance

By studying identical twins, we can study about the interaction of the environment with the genes and how it affects the growth and development of the body in general and dentofacial complex in particular. By utilizing twin studies, we can identify whether a particular trait, disease, or disorder is influenced more strongly by genetics or by the environment. Success of orthodontic treatment depends on a proper diagnosis of the problem including its etiological factors. Genetic studies let the orthodontists to understand the effects of genetic and environmental factors in the growth and development of dentofacial complex better and allows to prevent or treat malocclusions and skeletal anomalies in better ways.

How to cite this article

Manjusha KK, Jyothindrakumar K, Nishad A, Manoj KM. Growth and Development of Dentofacial Complex influenced by Genetic and Environmental Factors using Monozygotic Twins. J Contemp Dent Pract 2017;18(9):754-758.

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  1. Genetic and environmental influences on facial profile. Aust Dent J 1995 Apr;40(2):104-109.
  2. The heritability of malocclusion: Part 2. The influence of genetics in malocclusion. Br J Orthod 1999 Sep;26(3):195-203.
  3. Dental arch development in a set of triplets. Eur J Orthod 1992 Aug;14(4):273-279.
  4. Twin studies: a unique epidemiological tool. Indian J Community Med 2016 Jul-Sep;41(3):177-182.
  5. A twin-pronged attack on complex traits. Nat Genet 1997 Dec;17(4):387-392.
  6. The value of twins in dental research. Aust Dent J 2003 Jun;48(2):82-88.
  7. Diagnostic efficiency of fingerprint and blood group differences in a series of twins. Acta Genet Med Gemellol (Roma) 1968 Apr;17(2):359-374.
  8. Diagnosis of zygosity by questionnaire and polymarker polymerase chain reaction in young twins. Behav Genet 1999 Mar;29(2):115-123.
  9. Efficient sequential search of genetic systems for diagnosis of twin zygosity. Acta Genet Med Gemellol (Roma) 1991;40(2):159-164.
  10. Diagnosis of twin zygosity by hypervariable RFLP markers. Am J Med Genet 1991 Oct;41(1):96-98.
  11. Genetic analysis of occlusal variation in twins. Am J Orthod 1980 Aug;78(2):140-154.
  12. ; Fizzell, JA. Technique and treatment with light-wire edgewise appliance. St. Louis (MO): C.V. Mosby Co.; 1972.
  13. Heritability of 39 orthodontic cephalometric parameters on MZ, DZ twins and MN-paired singletons. Am J Orthod Dentofacial Orthop 1997 Jan;111(1):44-51.
  14. An analysis of cephalometric polygons in 21 sets of triplets. Bilt Udruz Ortodonata Jugosl 1991;24(2):79-84.
  15. Craniofacial morphology and occlusal variation in monozygous and dizygous twins. Angle Orthod 1987 Jul;57(3):219-233.
  16. Inheritance of craniofacial morphology. Angle Orthod 1972 Oct;42(4):339-351.
  17. A comparison of vertical and horizontal cephalometric variables with regard to heritability. Eur J Orthod 1987 May;9(2):104-108.
  18. A quantitative genetic study of cephalometric variables in twins. Clin Orthod Res 2001 Aug;4(3):130-140.
  19. Genetic variability of craniofacial dimensions. Angle Orthod 1973 Apr;43(2):207-215.
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