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VOLUME 18 , ISSUE 10 ( October, 2017 ) > List of Articles

RESEARCH ARTICLE

Study to assess Activity and Concentration of Gammaglutamyl Transpeptidase in Precancerous and Cancer Patients and Its Comparison with Controls

Mitesh D Kathariya, Anjum AJ Farooqui, Sayeedalaeque Bangi, Yogita J Khalekar, Neha D Nikumbh, Keeran B Jadhav

Citation Information : Kathariya MD, Farooqui AA, Bangi S, Khalekar YJ, Nikumbh ND, Jadhav KB. Study to assess Activity and Concentration of Gammaglutamyl Transpeptidase in Precancerous and Cancer Patients and Its Comparison with Controls. J Contemp Dent Pract 2017; 18 (10):943-946.

DOI: 10.5005/jp-journals-10024-2154

Published Online: 01-12-2015

Copyright Statement:  Copyright © 2017; The Author(s).


Abstract

Objective

The purpose of the study is to highlight the use of gamma-glutamyl transpeptidase (GGT) as salivary enzyme tumor marker and assess the activity and concentration of GGT in precancerous and cancer patients and compare it with the normal control.

Materials and methods

Individuals in the age group of above 20 years were included in the study. In this study, salivary GGT was analyzed in 75 cases. The selected patients were divided into three main groups as group I (controls with normal health), group II (patients with precancerous lesions and conditions), and group III (patients with oral cancer lesions). All the selected individuals were analyzed for salivary GGT.

Results

A significant difference was observed between control and precancerous groups with GGT values at 5% level of significance. The mean GGT value is significantly higher in precancerous group as compared with control group (p < 0.05). A significant difference was observed between control and cancerous groups with GGT values at 5% level of significance. The mean GGT value is significantly higher in cancerous group as compared with control group (p < 0.05). A significant difference was observed between precancerous and cancerous groups with GGT values at 5% level of significance. The mean GGT value is significantly higher in cancerous group as compared with precancerous group (p < 0.05).

Conclusion

There is a remarkable increase in salivary GGT activity in both precancerous and cancerous conditions. The increased activity was more marked in cancerous conditions than in precancerous conditions. The GGT levels were two- to threefold increased in precancerous conditions as compared with control group. This finding was statistically significant and also suggested the strong correlation between GGT levels and presence of precancerous conditions.

Clinical significance

Integration of all these observation strengthens our thinking that elevation of salivary GTT in precancerous and cancerous conditions can be a reliable biomarker in early detection and prevention of oral malignancy.

How to cite this article

Farooqui AAJ, Thete SG, Bangi S, Khalekar YJ, Nikumbh ND, Jadhav KB, Kathariya MD. Study to assess Activity and Concentration of Gamma-glutamyl Transpeptidase in Precancerous and Cancer Patients and Its Comparison with Controls. J Contemp Dent Pract 2017;18(10):943-946.

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  1. ; Robbins, SL.; Cotran, RS. Pathologic basis of diseases. 5th ed. New York, Philadelphia (PA), Pennsylvania: Elsevier Publisher; 2004. p. 270, 272, 279, 280.
  2. Park's textbook of preventive and social medicine. 18th ed. Jabalpur: M/s Banarasidas Bhanot; 2005. p. 307.
  3. The diagnostic applications of saliva – a review. Int Am Assoc Dent Res 2002 Feb;13(2):197-212.
  4. ; Shinde, R. Text book of biochemistry. 7th ed. New Delhi: Jaypee Brothers Medical Publishers; 2008. p. 751.
  5. Gamma-glutamyl transpeptidase activity in human oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol 1987 Aug;64(2):197-201.
  6. Gamma-glutamyl transpeptidase in precancerous lesions and carcinomas of oral, pharyngeal, and laryngeal mucosa. Cancer 1985 Jul;56(1):138-143.
  7. Multiple forms of gamma-glutamyl transpeptidase in human submandibular gland. Clin Chem Acta 1991 Mar;197(2):133-139.
  8. Abnormal expression of hepatoma-derived gamma-glutamyl transferase subtyping and its early alteration for carcinogenesis of hepatocytes. Hepatobiliary Pancreat Dis Int 2004 Nov;3(4):564-570.
  9. Gamma-glutamyltransferase and alkaline phosphatase in the serum and saliva of patients with hepatic tumors and hepatic cirrhosis. Rev Esp Oncol 1984;31(2):315-319.
  10. Detection of a unique gamma-glutamyl transpeptidase messenger RNA species closely related to the development of hepatocellular carcinoma in humans: a new candidate for early diagnosis of hepatocellular carcinoma. Hepatology 1996 May;23(5):1093-1097.
  11. Gamma-glutamyltransferase, a common marker of human epithelial tumors? Cancer Detect Prev 1980;3(2):471-485.
  12. Hepatoma-related gamma-glutamyl transferase in laboratory or clinical diagnosis of hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int 2007 Feb;6(1):9-11.
  13. Significance of glutathione S-transferase-π as a tumor marker in patients with oral cancer. Cancer 1992 Nov;70(10):2381-2387.
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