The Journal of Contemporary Dental Practice

Register      Login

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue

Online First

Archive
Related articles

VOLUME 18 , ISSUE 11 ( November, 2017 ) > List of Articles

RESEARCH ARTICLE

Effect of Periodontal Therapy on Crevicular Fluid Interleukin-18 Level in Periodontal Health and Disease in Central Maharashtra (India) Population

Monica J Mahajani, Varsha A Jadhao, Pooja S Wankhade, Emmanuel Samson, Vishwas D Acharya, Pawankumar D Tekale

Citation Information : Mahajani MJ, Jadhao VA, Wankhade PS, Samson E, Acharya VD, Tekale PD. Effect of Periodontal Therapy on Crevicular Fluid Interleukin-18 Level in Periodontal Health and Disease in Central Maharashtra (India) Population. J Contemp Dent Pract 2017; 18 (11):1085-1089.

DOI: 10.5005/jp-journals-10024-2180

Published Online: 01-11-2017

Copyright Statement:  Copyright © 2017; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Aim

The incidence and progression of the periodontal disease depend on periodontal microflora and the multifaceted response of the host, and these interactions are mediated by cytokines and chemokines. Interleukin-18 (IL-18) is a proinflammatory cytokine of the IL-1 superfamily. The aim of the present study was the assessment of the periodontal therapy in IL-18 level in periodontal disease and health.

Materials and methods

Based on clinical attachment loss (CAL), probing pocket depth (PPD), gingival index (GI), and plaque index (PI) patients were divided into three groups: Group I with healthy patients, group II with chronic periodontitis, and group III with posttreatment patients having periodontitis.

Results

Mean PI, PPD, CAL, and gingival crevicular fluid (GCF) volume were significantly higher in groups II and III compared with group I. However, there were no significant differences between GI in groups I, II, and III. The total amount of IL-18 in GCF was significantly higher in group II when compared with groups I and III (p < 0.05).

Conclusion

The present study confirmed that the IL-18 level in GCF was lower in healthy patients, higher in periodontally involved patients, and reduced at baseline, 3 and 6 weeks after nonsurgical periodontal therapy.

Clinical significance

The IL-18 might be hypothetically beneficial in distinguishing health from disease and monitoring periodontal disease activity.

How to cite this article

Mahajani MJ, Jadhao VA, Wankhade PS, Samson E, Acharya VD, Tekale PD. Effect of Periodontal Therapy on Crevicular Fluid Interleukin-18 Level in Periodontal Health and Disease in Central Maharashtra (India) Population. J Contemp Dent Pract 2017;18(11):1085-1089.


PDF Share
  1. ; Takei, H.; Klokkevold, PR.; Carranza, FA. Carranza's clinical periodontology. 10th ed. St. Louis (MO): Saunders; 2012. p. 349-350.
  2. Clinical, pathological and immunological aspects of periodontal disease. Acta Odontol Scand 2001 Jul;59(3):154-160.
  3. Balance of inflammatory response in stable gingivitis and progressive periodontitis lesions. Clin Exp Immunol 2006 Apr;144(1):35-40.
  4. Exploring the role of Th1 cytokines: Interleukin-17 and interleukin-18 in periodontal health and disease. J Oral Sci 2009 Jun;51(2):261-266.
  5. Correlation of levels of interleukin-1β in gingival crevicular fluid to the clinical parameters of chronic periodontitis. J Contemp Dent Pract 2011 Jan;12(1):52-59.
  6. Interleukin-18 concentrations and the pathogenesis of periodontal disease. J Periodontol 2005 May;76(5):785-790.
  7. Immunoregulatory functions of interleukin 18 and its role in defense against bacterial pathogens. J Mol Med (Berl) 2002 Mar;80(3):147-162.
  8. Interleukin-18 regulates both Th1 and Th2 responses. Annu Rev Immunol 2001 Apr;19:423-474.
  9. Increased interleukin-18 in gingival crevicular fluid from periodontitis patients. Oral Microbiol Immunol 2008 Apr;23(2):173-176.
  10. Interleukin-17 and interleukin-18 levels in saliva and plasma of patients with chronic periodontitis. J Periodontal Res 2011 Oct;46(5):592-598.
  11. Interleukin-18 (interferon-gamma-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony-stimulating factor and not via interferon-gamma to inhibit osteoclast formation. J Exp Med 1997 Mar;185(6):1005-1012.
  12. IL-12 alone and in synergy with IL-18 inhibits osteoclast formation in vitro. J Immunol 2001 Apr;166(8):4915-4921.
  13. Effectiveness of non-surgical treatment to reduce il-18 levels in the gingival crevicular fluid of patients with periodontal disease. Braz Dent J 2012;23(4):428-432.
  14. Estimation of interleukin-18 in the gingival crevicular fluid and serum of Bengali population with periodontal health and disease. J Indian Soc Periodontol 2016 May-Jun;20(3):260-264.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.