Effect of Topical Honey on Mandibular Bone
Defect Healing in Rats
Bahman Derakhshan, Farhad Hajizadeh, Zahra Abbasi
Citation Information :
Derakhshan B, Hajizadeh F, Abbasi Z. Effect of Topical Honey on Mandibular Bone Defect Healing in Rats. J Contemp Dent Pract 2018; 19 (1):47-51.
pharmacological effects, from wound dressing to anticancerogenic
and from anti-inflammatory to antibacterial activities. The
aim of the current study was to evaluate the effect of honey on
healing of mandibular bone defects in a rat model.
Materials and methods: This animal study was performed on
24 wild-type Wistar rats. Following shaving, disinfection, and
extraoral incision, a 2 × 2 mm defect was created at mandibular
angle. In the experimental group, the defect was filled with sterile
honey, while it was left unfilled in the control group. The rats
were sacrificed after 2 and 4 weeks and defects were assessed
histologically. The results were compared using Mann–Whitney
U-test (α = 0.05).
Results: After 2 weeks, five samples of the experimental group
were in mineralization phase, while all samples of the control
group were in the vascularization phase (p = 0.015). After
4 weeks, the defects were filled in four samples of the experimental
group, while all samples of the control group were
in the mineralization stage (p = 0.002). Histomorphometric
assessment revealed that the mean new bone formation in
the experimental group was significantly more than the control
group, both after 2 and 4 weeks (p = 0.041).
Conclusion: The results showed that honey could accentuate
bone healing of mandibular small defects in rats.
Clinical significance: Honey might have potential in repair of
human alveolar bone defects.
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