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VOLUME 8 , ISSUE 4 ( May, 2007 ) > List of Articles


Giant Cell Lesions with a Noonan-like Phenotype: A Case Report

Manoel Sant'Ana Filho, Claudia Marcela H. Cancino, Léonilson Gaião, Flavio Augusto Marsiaj Oliveira

Citation Information : Filho MS, Cancino CM, Gaião L, Oliveira FA. Giant Cell Lesions with a Noonan-like Phenotype: A Case Report. J Contemp Dent Pract 2007; 8 (4):67-73.

DOI: 10.5005/jcdp-8-4-67

License: CC BY-NC 3.0

Published Online: 01-09-2008

Copyright Statement:  Copyright © 2007; The Author(s).



The purpose of this article is to describe a case of multiple giant cell lesions of the mandible that occurred in a 14-year-old girl with phenotypic characteristics associated with Noonan Syndrome (NS).


NS is a dysmorphic disorder characterized by hypertelorism, short stature, congenital heart defects, short and webbed neck, skeletal anomalies, and bleeding diathesis.


A 14-year-old girl with a previous diagnosis of NS (sporadic case) presented with multiple radiolucent lesions in the body and ramus of her mandible.


In terms of clinical behavior and the described radiographic characteristics, giant cells lesions with Noonan-like phenotype can be considered a form of cherubism. Therefore, surgical intervention is not necessary, but radiographic follow-up and observation is very important during the control and gradual regression of the lesions.


Cancino CMH, Gaião L, Sant'Ana Filho M, Oliveira FAM. Giant Cell Lesions with a Noonan-like Phenotype: A Case Report. J Contemp Dent Pract 2007 May;(8)4:067-073.

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